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Curcumin acts synergistically with fluconazole to sensitize a clinical isolate of Candida albicans showing a MDR phenotype.
We assessed whether the resistance of this isolate was the result of the existence of efflux pumps, which could confer a multiple drug resistance phenotype. To evaluate azole resistance, we used the Clinical Laboratory Standard Institute (CLSI) MIC assays procedures with minor modifications. For eva...
A case of bovine valve endocarditis caused by Engyodontium album.
We report the first case of Engyodontium album bioprosthetic valve endocarditis in a 44-year-old male with a history of juvenile rheumatoid arthritis. There is only one other report of Engyodontium album as a human pathogen. The present case supports the increased incidence of fungal endocarditis esp...
Invasive squamous cell carcinoma arising from chromoblastomycosis.
Chromoblastomycosis is a chronic subcutaneous mycosis seen mainly in tropical regions. While malignant transformation rarely occurs, the present report describes a 69-year-old man with a 21-year history of chromoblastomycosis complicated by invasive squamous cell carcinoma requiring...
Phaeohyphomycosis caused by a plant pathogen, Corynespora cassiicola.
We report a case of subcutaneous phaeohyphomycosis caused by Corynespora cassiicola. Molecular identification of this pathogen on grasses confirms that it may be involved in human infection, as previously reported once in pre-molecular literature. In vitro antifungal susceptibility data of the strai...
Kodamaea (Pichia) ohmeri fungemia in a pediatric patient admitted in a public hospital.
Kodamaea (Pichia) ohmeri is a yeast species that has not been reported to be a frequent cause of human infections. The current report describes a case of fungemia caused by K. ohmeri in a 3-year-old female patient hospitalized in the public hospital Maria Alice Fernandes, Natal, RN, Brazil. The pati...
Eumycetoma caused by Cladophialophora bantiana successfully treated with itraconazole.
A 57-year-old male presented with dermatosis of the dorsum of the foot consisting of tumefaction, deformity and sinus tract formation. The direct examination of exudates as well as the biopsy tissue, demonstrated the presence of black granules. A dematiaceous fungus was isolated from the lesions and...
Canine sino-nasal aspergillosis: parallels with human disease
Canine sino-nasal aspergillosis (SNA) is characterized by the formation of a superficial mucosal fungal plaque within the nasal cavity and/or frontal sinus of systemically healthy dogs. The most common causative agent is Aspergillus fumigatus. The fungus does not invade beneath the level of mucosal...
Deactivation of the dimorphic fungi Histoplasma capsulatum, Blastomyces dermatitidis and Coccidioides immitis using hydrogen peroxide vapor.
Hydrogen peroxide vapour (HPV) has been proposed as an alternative to formaldehyde fumigation for the decontamination of biosafety level (BSL) III laboratories. The aim of this study was to evaluate the efficacy of HPV against the dimorphic fungi Histoplasma capsulatum, Blastomyces dermatitidis and...
Successfully treated Candida krusei infection of the lumbar spine with combined caspofungin/posaconazole therapy.
We report on a case of vertebral osteomyelitis caused by Candida krusei in a patient who had neutropenia as a result of chemotherapy for acute myelogenous leukaemia. The patient received prophylactic liposomal amphotericin B during chemotherapy but became febrile and experienced severe lumbar pain....
Molecular detection of Microsporum persicolor in soil suggesting widespread dispersal in central India.
A survey was conducted from 1999 to 2003 as part of a microbial biodiversity study on geophilic and keratinophilic fungi in central India. Among the keratinophilic fungi recovered were 82 isolates belonging to the dermatophyte genus Microsporum. Species were provisionally identified by morphology and...