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Olesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis.
I clinical trials of olesoxime have been completed successfully. Olesoxime is well tolerated and achieves levels predicted to be clinically effective when administered orally. It has been granted orphan drug status for the treatment of ALS in the US and for the treatment of spinal muscular atrophy i...
Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis.
Recent years have seen an explosion of research into increasingly prevalent neurodegenerative diseases. Arimoclomol (BRX-220), being developed by CytRx Corp, is an oral therapeutic candidate for the treatment of amyotrophic lateral sclerosis (ALS), the most common form of motor neuron disease. ALS i...
Uncovering the therapeutic potential of natural products with biomarker-guided screening.
Biomarker-guided screening is a multidisciplinary approach that can be used to facilitate early drug discovery from natural products. By integrating powerful genomic tools and the rapidly expanding knowledge of biomarkers, the screening systematically identifies compounds with therapeutic potential...
SUMO, Ubiquitin, UBL Proteins: Implications For Human Diseases - Fifth International Conference.
The fifth international conference on SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases, held in Houston, included topics covering the latest advances and new targets in the field of protein modification. This conference report highlights selected presentations on the structural charact...
Bringing DNA vaccines closer to commercial use.
Progress in the application of DNA vaccines as an immunization protocol is evident from the increasing number of such vaccines under evaluation in clinical trials and by the recent approval of several DNA vaccine products for veterinary applications. DNA vaccine technology offers important therapeut...
Biotechnology-2009 AAPS national conference. 21-24 June 2009, Seattle, WA, USA.
Translational biomarkers for accelerating drug development: From preclinical to clinical - AAPS Workshop.
American Chemical Society - 237th national meeting & exposition. Part 1.
Novel therapeutic strategies in prostate cancer: establishing a stratification system for patient selection in targeted trials.
Currently, the standard treatment for metastatic hormone-refractory prostate cancer includes a combination regimen with docetaxel and prednisone. Although such therapy has been demonstrated to improve survival compared with previous standards of treatment, the regimen is not curative. In efforts to...
British Association for Psychopharmacology--2008 Summer Meeting.