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- Metapress, Gale, Rcgp, Ovid from 1998, CSA, Springer, Ingenta, and Proquest
Superparamagnetic microrobots: fabrication by two-photon polymerization and biocompatibility.
We demonstrate that the helical microdevices made of 2 vol.% MPC were capable of performing corkscrew motion in water applying weak uniform rotating magnetic fields....
A new experimental system for simultaneous application of cyclic tensile strain and fluid shear stress to tenocytes in vitro.
Tenocyte mechanotransduction has been of great interest to researchers in tendon mechanobiology and biomechanics. In vivo, tenocytes are subjected to tensile strain and fluid shear stress, but most studies of tenocyte mechanobiology have been to understand how tenocytes regulate their functions in r...
Subcutaneous blood pressure monitoring with an implantable optical sensor.
We introduce a minimally invasive, implantable system that uses pulse transit time to determine blood pressure. In contrast to previous approaches, the pulse wave is detected by a photoplethysmographic (PPG) signal, acquired with high quality directly on subcutaneous muscle tissue. Electrocardiogram...
Hollow three-dimensional endothelialized microvessel networks based on femtosecond laser ablation.
In this study, a novel method for the fabrication of hollow three-dimensional (3D) poly(lactic-co-glycolic acid) (PLGA) microvessel scaffolds is proposed. In this novel fabrication method, a salt ingot, which was used as a temporary frame to define the shape of the desired scaffold, was fabricated b...
Microfluidics and cancer: are we there yet?
We present a review of role of microlfuidcs in cancer research, including the history, recent advances and future directions to explore where the field stand currently in addressing complex clinical challenges and future of it. This review identifies four critical areas in cancer research, in which...
Towards an optimal and unbiased approach for tumor cell isolation.
We present a negative enrichment approach, integrating WBC depletion and chemical-free RBC depletion in the same setup without the need for centrifugation, washing or multiple sample handling steps. This approach achieves an average of >90 % recovery of spiked tumor cells and >99 % total WBC depleti...
Fibroblasts influence muscle progenitor differentiation and alignment in contact independent and dependent manners in organized co-culture d...
We utilized a reconfigurable co-culture device to understand the contact and paracrine effects of fibroblasts on skeletal myocyte alignment and differentiation using murine myoblast and fibroblast cell lines. We demonstrate that myotube alignment is increased by direct contact with fibroblasts, whil...
Determination of the size distribution of blood microparticles directly in plasma using atomic force microscopy and microfluidics.
Microparticles, also known as microvesicles, found in blood plasma, urine, and most other body fluids, may serve as valuable biomarkers of diseases such as cardiovascular diseases, systemic inflammatory disease, thrombosis, and cancer. Unfortunately, the detection and quantification of microparticle...
Mesh-supported submicron parylene-C membranes for culturing retinal pigment epithelial cells.
We first measure the permeability of submicron parylene-C and find that 0.15-0.30 μm parylene-C has similar permeability to healthy human Bruch's membranes. Blind-well perfusion cell viability experiments further demonstrate that nutrients and macromolecules can diffuse across 0.30 μm parylene-C...
Microfabricated scaffold-guided endothelial morphogenesis in three-dimensional culture.
We have developed a bioreactor system for scaffold-guided tubulogenesis coupled with 3-D organotypic culture to spatially control vessel formation and its orientation. To create microchannels to guide microvessel formation, we fabricated rigid scaffolds using photolithography and light curing epoxy,...