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Pharmaceutical Biology

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  1. Osthole induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.

    Pharmaceutical Biology 52(5):544 (2014) PMID 24236568

    Osthole exhibited significant inhibition of the survival of HepG2 cells and the half inhibitory concentration (IC50) values were 0.186, 0.158 and 0.123 µmol/ml at 24, 48 and 72 h, respectively. Cells treated with osthole at concentrations of 0, 0.004, 0.02, 0.1 and 0.5 μmol/ml showed a statistically...
  2. Anti-Helicobactor pylori activity of some Jordanian medicinal plants.

    Pharmaceutical Biology 52(5):566 (2014) PMID 24251817

    Results showed that ethanol extracts of most medicinal plants exerted cytotoxiciy against H. pylori isolates. Among the tested plant extracts, A. triphylla (MIC: 90 µg/mL, MBC: 125 µg/mL) and I. viscosa (MIC: 83 µg/mL, MBC: 104 µg/mL) showed the strongest activity against both isolates of H. pylori....
  3. Effect of hydroalcoholic extract of Aegle marmelos fruit on radical scavenging activity and exercise-endurance capacity in mice.

    Pharmaceutical Biology 52(5):551 (2014) PMID 24707972

    Our study demonstrates the anti-fatigue properties of A. marmelos fruit, most probably manifested by delaying the accumulation of serum lactic acid, increasing the fat utilization and up-regulating the skeletal muscle metabolic regulators....
  4. Evaluation of in silico, in vitro α-amylase inhibition potential and antidiabetic activity of Pterospermum acerifolium bark.

    Pharmaceutical Biology 52(2):199 (2014) PMID 24074272

    Pterospermum acerifolium (L.) Willd (Sterculiaceae) has been traditionally used in the treatment of diabetes mellitus but no scientific data has been published supporting the claimed ethnomedical use. The present study was designed to estimate the in silico, in vitro α-amylase inhibition potential a...
  5. Antiepileptogenic effect of curcumin on kainate-induced model of temporal lobe epilepsy.

    Pharmaceutical Biology 51(12):1572 (2013) PMID 24004105

    Temporal lobe epilepsy (TLE) is an intractable neurological disorder. Curcumin is the bioactive component of turmeric with anti-epileptic and neuroprotective potential. The beneficial effect of curcumin on the intrahippocampal kainate-induced model of TLE was investigated. Rats were divided into sha...
  6. Anti-inflammatory, anti-lipid peroxidative, antioxidant and membrane stabilizing activities of hydroalcoholic extract of Terminalia chebula ...

    Pharmaceutical Biology 51(12):1515 (2013) PMID 24004166

    Arthritis is inflammation of one or more joints. Terminalia chebula Retz. (Combretaceae) fruit is mentioned in Ayurveda as useful in treating arthritic disorders. This work was undertaken to evaluate the anti-inflammatory, antioxidant, anti-lipid peroxidative and membrane-stabilizing effects of hydr...
  7. Anticancer activity of Saussurea lappa extract by apoptotic pathway in KB human oral cancer cells.

    Pharmaceutical Biology 51(11):1372 (2013) PMID 23855888

    We performed DNA fragmentation assay, western blot, caspase activity assay and fluorescence-activated cell sorting (FACS) analysis. Treatment of S. lappa extract onto KB cells reduced cell viability significantly with an IC50 value of 30 µg/ml. The formation of a DNA ladder was observed starting at...
  8. Magnesium lithospermate B reduces myocardial ischemia/reperfusion injury in rats via regulating the inflammation response.

    Pharmaceutical Biology 51(11):1355 (2013) PMID 23863120

    Our study provided evidence that MLB ameliorated the inflammatory process associated with MI/R injury via NF-κB inactivation....
  9. Botanicals in Ribes nigrum bud-preparations: an analytical fingerprinting to evaluate the bioactive contribution to total phytocomplex.

    Pharmaceutical Biology 51(10):1282 (2013) PMID 23844599

    CONTEXT. Ribes nigrum L. (Grossulariaceae) is among the most commonly used herbal medicines and it is popularized for its alleged tonic effect and curative and restorative properties. The current practice of identifying herbal extracts is by measuring the concentration of the main botanicals. Their...
  10. Hepatoprotection of 1β-hydroxyeuscaphic acid - the major constituent from Rubus aleaefolius against CCl4-induced injury in hepatocytes cells...

    Pharmaceutical Biology 51(6):686 (2013) PMID 23527895

    These results provide a basis for confirming the traditional uses of R. aleaefolius in treating hepatic diseases....