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Pharmaceutical Biology

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  1. Mutagenic biomonitoring of pirethroid insecticides in human lymphocyte cultures: Use of micronuclei as biomarkers and recovery by Rosa canin...

    Pharmaceutical Biology 53(5):625 (2015) PMID 25330814

    We determined the ability of the water (RCwtr) and ethanol (RCeta) extracts of rosehip (R. canina) to overcome the possible genotoxic effects of the insecticides. Preliminary studies determined that the application concentrations were 20, 30, 40, and 50 ppm for cypermethrin, 25, 50, 75, and 100 ppm...
  2. Chrysanthemum boreale flower floral water inhibits platelet-derived growth factor-stimulated migration and proliferation in vascular smooth ...

    Pharmaceutical Biology 53(5):725 (2015) PMID 25330930

    These results demonstrate that CBMFF may inhibit PDGF-BB-induced vascular migration and proliferation, most likely through inhibition of the PDGFR-β-mediated MAPK pathway; therefore, the CBMFF may be promising candidate for the development of herbal remedies for vascular disorders....
  3. In vitro enhancement of psoralen as an important anticancer compound in Psoralea corylifolia through precursor feeding.

    Pharmaceutical Biology 53(5):735 (2015) PMID 25331001

    Psoralea corylifolia L. (Fabacese) is rich source of bioactive compounds, which endows the plant with immense value for its use in pharmaceuticals, health, and body-care products. The current study was designed (i) for the determination of psoralen from callus derived from different plant parts, and...
  4. Simultaneous quantification and validation of new peroxynitrite scavengers from Artemisia iwayomogi.

    Pharmaceutical Biology 53(5):653 (2015) PMID 25474707

    Artemisia iwayomogi Kitamura (Compositae) has been very widely used for the treatment of acute or chronic hepatitis, jaundice, and gastritis. In the course of our continuing efforts to identify and quantify peroxynitrite scavengers from Compositae plants, A. iwayomogi was used in this study. The pre...
  5. Mangiferin activates the Nrf2-ARE pathway and reduces etoposide-induced DNA damage in human umbilical cord mononuclear blood cells.

    Pharmaceutical Biology 53(4):503 (2015) PMID 25380307

    We found that mangiferin treatment significantly reduced DNA damage in etoposide-treated MNCs, which was verified by decreased olive tail moment (OTM) and micronucleus (MN) frequency. Mangiferin treatment significantly promoted Nrf2 translocation into the nucleus and increased nuclear Nrf2 expressio...
  6. Antidiabetic, antioxidant, and TNF-α lowering properties of extract of the traditionally used plant Ixeris gracilis in alloxan-induced diabe...

    Pharmaceutical Biology 53(4):494 (2015) PMID 25474076

    Abstract Context: Ixeris gracilis DC. Stebbins (Asteraceae) is a plant considered to be medicinal by local communities of Meghalaya, India. To evaluate the antidiabetic potential, antioxidant activity, and effect of the 80% methanolic extract of the leaves of Ixeris gracilis on tumor necrosis factor...
  7. Genoprotective effects of Origanum vulgare ethanolic extract against cyclophosphamide-induced genotoxicity in mouse bone marrow cells.

    Pharmaceutical Biology 53(1):92 (2015) PMID 25519883

    Cyclophosphamide (CP), an alkylating chemotherapeutic agent, can bind DNA, causing chromosome breaks, micronucleus (Mn) formation, and cell death. Because Origanum vulgare L. (Lamiaceae) has antioxidative properties, it might protect against DNA damage. The genoprotective effect of O. vulgare ethano...
  8. Evaluation of antidiabetic properties of cactus pear seed oil in rats.

    Pharmaceutical Biology 52(10):1286 (2014) PMID 25026333

    Cactus pear (Opuntia ficus-indica (L.) Mill. (Cactaceae)) is a medicinal plant widely used to treat diabetes. This work investigates the hypoglycemic and antihyperglycemic effect of cactus pear seed oil (CPSO), its mechanism of action, and any toxic effects. The hypoglycemic effect of CPSO was evalu...
  9. α-Glucosidase inhibition, 15-lipoxygenase inhibition, and brine shrimp toxicity of extracts and isolated compounds from Terminalia macropter...

    Pharmaceutical Biology 52(9):1166 (2014) PMID 24635511

    Terminalia macroptera Guill. & Perr. (Combretaceae), a tree that grows in West Africa, has been used in traditional medicine against a variety of diseases such as hepatitis, gonorrhea, skin diseases, and diabetes. To investigate enzyme inhibitory activity against α-glucosidase and 15-lipoxygenase (1...
  10. Ardisiphenol D, a resorcinol derivative identified from Ardisia brevicaulis, exerts antitumor effect through inducing apoptosis in human non...

    Pharmaceutical Biology 52(7):797 (2014) PMID 24392814

    We have isolated and identified some chemical constituents from this plant. Furthermore, these compounds showed significant inhibition of the proliferation of human pancreatic PANC-1, human lung A549, human gastrointestinal carcinoma SGC 7901, human breast MCF-7, and human prostate PC-3 cancer cells...