Breast Cancer Research (Online Edition)

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  1. Estimated dietary dioxin exposure and breast cancer risk among women from the French E3N prospective cohort.

    Breast Cancer Research (Online Edition) 17(1):536 (2015) PMID 25778372 PMCID PMC4362830

    Dioxins are environmental and persistent pollutants mostly emitted from combustion facilities (e.g. waste incinerators, metal and cement industries). Known to be endocrine disrupting chemicals, dioxins are suspected to increase breast cancer (BC) risk. Although diet is considered the primary sou...
  2. Molecular subtyping for clinically defined breast cancer subgroups.

    Breast Cancer Research (Online Edition) 17(1):520 (2015) PMID 25778358 PMCID PMC4365540

    Breast cancer is commonly classified into intrinsic molecular subtypes. Standard gene centering is a routinely done prior to molecular subtyping but can produce inaccurate classifications when the distribution of clinicopathological characteristics in the study cohort differs from that of the tr...
  3. Pleiotropic functions of the tumor- and metastasis-suppressing Matrix Metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice.

    Breast Cancer Research (Online Edition) 17(1):545 (2015) PMID 25778380 PMCID PMC4380014

    Matrix metalloproteinase-8 (MMP-8; neutrophil collagenase) is an important regulator of innate immunity which has onco-suppressive actions in numerous tumor types. We have intercrossed Mmp8-null mice with the Polyoma virus middle T oncogene-driven (MMTV-PyMT) mouse model of mammary cancer to exp...
  4. Lobular breast cancer: incidence and genetic and non-genetic risk factors.

    Breast Cancer Research (Online Edition) 17(1):546 (2015) PMID 25778381 PMCID PMC4357148

    While most invasive breast cancers consist of carcinomas of the ductal type, about 10% are invasive lobular carcinomas. Invasive lobular and ductal carcinomas differ with respect to risk factors. Invasive lobular carcinoma is more strongly associated with exposure to female hormones, and therefo...
  5. FOXF2 deficiency promotes epithelial-mesenchymal transition and metastasis of basal-like breast cancer.

    Breast Cancer Research (Online Edition) 17(1):531 (2015) PMID 25778367 PMCID PMC4361145

    Our previous clinical study demonstrated that the under-expression of FOXF2 is associated with early-onset metastasis and poor prognosis of patients with triple-negative breast cancer. In this study, we further characterized the role of FOXF2 in metastasis of basal-like breast cancer (BLBC) and ...
  6. Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer.

    Breast Cancer Research (Online Edition) 17(1):498 (2015) PMID 25778352 PMCID PMC4303225

    Cancer genomic DNA sequences enable identification of all mutations and suggest targets for precision medicine. The identities and patterns of the mutations themselves also provide critical information for deducing the originating DNA damaging agents, causal molecular mechanisms, and thus additi...
  7. Erratum to: "A novel role for ezrin in breast cancer angio/lymphangiogenesis".

    Breast Cancer Research (Online Edition) 17(1):511 (2015) PMID 25778353 PMCID PMC4304170

  8. Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management.

    Breast Cancer Research (Online Edition) 17(1):526 (2015) PMID 25778362 PMCID PMC4332424

    MicroRNAs (miRNAs) are an emerging class of gene expression modulators with relevant roles in several biological processes, including cell differentiation, development, apoptosis, and regulation of the cell cycle. Deregulation of those tiny RNA molecules has been described frequently as a major ...
  9. Patient-derived xenograft models of breast cancer and their predictive power.

    Breast Cancer Research (Online Edition) 17(1):523 (2015) PMID 25778360 PMCID PMC4323263

    Despite advances in the treatment of patients with early and metastatic breast cancer, mortality remains high due to intrinsic or acquired resistance to therapy. Increased understanding of the genomic landscape through massively parallel sequencing has revealed somatic mutations common to specif...
  10. Prognostic stromal gene signatures in breast cancer.

    Breast Cancer Research (Online Edition) 17(1):23 (2015) PMID 25848820 PMCID PMC4360948

    Global gene expression analysis of tumor samples has been a valuable tool to subgroup tumors and has the potential to be of prognostic and predictive value. However, tumors are heterogeneous, and homogenates will consist of several different cell types. This study was designed to obtain more ref...
  11. Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy.

    Breast Cancer Research (Online Edition) 17(1):18 (2015) PMID 25849327 PMCID PMC4374346

    Tumor lymphocyte infiltration is associated with clinical response to chemotherapy in estrogen receptor (ER) negative breast cancer. To identify variants in immunosuppressive pathway genes associated with prognosis after adjuvant chemotherapy for ER-negative patients, we studied stage I-III inva...
  12. Invasive lobular carcinoma of the breast: morphology, biomarkers and 'omics.

    Breast Cancer Research (Online Edition) 17(1):12 (2015) PMID 25849106 PMCID PMC4310190

    Invasive lobular carcinoma of the breast is the most common 'special' morphological subtype of breast cancer, comprising up to 15% of all cases. Tumours are generally of a good prognostic phenotype, being low histological grade and low mitotic index, hormone receptor positive and HER2, p53 and b...
  13. Combined histone deacetylase inhibition and tamoxifen induces apoptosis in tamoxifen-resistant breast cancer models, by reversing Bcl-2 overexpression.

    Breast Cancer Research (Online Edition) 17(1):26 (2015) PMID 25848915 PMCID PMC4367983

    The emergence of hormone therapy resistance, despite continued expression of the estrogen receptor (ER), is a major challenge to curing breast cancer. Recent clinical studies suggest that epigenetic modulation by histone deacetylase (HDAC) inhibitors reverses hormone therapy resistance. However,...
  14. Gene-expression molecular subtyping of triple-negative breast cancer tumours: importance of immune response.

    Breast Cancer Research (Online Edition) 17(1):43 (2015) PMID 25887482 PMCID PMC4389408

    Triple-negative breast cancers need to be refined in order to identify therapeutic subgroups of patients. We conducted an unsupervised analysis of microarray gene-expression profiles of 107 triple-negative breast cancer patients and undertook robust functional annotation of the molecular entitie...
  15. Tumor expression, plasma levels and genetic polymorphisms of the coagulation inhibitor TFPI are associated with clinicopathological parameters and survival in breast cancer, in contrast to the coagulation initiator TF.

    Breast Cancer Research (Online Edition) 17:44 (2015) PMID 25882602 PMCID PMC4423106

    Hypercoagulability in malignancy increases the risk of thrombosis, but is also involved in cancer progression. Experimental studies suggest that tissue factor (TF) and tissue factor pathway inhibitor (TFPI) are involved in cancer biology as a tumor- promoter and suppressor, respectively, but the...
  16. Benefits and harms of mammography screening.

    Breast Cancer Research (Online Edition) 17:63 (2015) PMID 25928287 PMCID PMC4415291

    Mammography screening for breast cancer is widely available in many countries. Initially praised as a universal achievement to improve women's health and to reduce the burden of breast cancer, the benefits and harms of mammography screening have been debated heatedly in the past years. This revi...
  17. Anti-CCL2: building a reservoir or opening the floodgates to metastasis?

    Breast Cancer Research (Online Edition) 17(1):68 (2015) PMID 25990313 PMCID PMC4438584

    Neutralisation of macrophage chemoattractant C-C chemokine ligand 2 (CCL2) has shown reduced metastasis and enhanced survival in numerous experimental models of tumorigenesis. However, important new findings reported in Nature by Momo Bentires-Alj's laboratory demonstrate that withdrawal of anti...
  18. Granulocytic immune infiltrates are essential for the efficient formation of breast cancer liver metastases.

    Breast Cancer Research (Online Edition) 17:45 (2015) PMID 25882816 PMCID PMC4413545

    Breast cancer cells display preferences for specific metastatic sites including the bone, lung and liver. Metastasis is a complex process that relies, in part, on interactions between disseminated cancer cells and resident/infiltrating stromal cells that constitute the metastatic microenvironmen...
  19. Reduced proliferation in breast cancer cells contacting the neighboring adipocytes in human breast cancer tissues.

    Breast Cancer Research (Online Edition) 17(1):90 (2015) PMID 26134401

  20. The effect of weight change on changes in breast density measures over menopause in a breast cancer screening cohort.

    Breast Cancer Research (Online Edition) 17(1):74 (2015) PMID 26025139 PMCID PMC4487974

    High weight and high percentage mammographic breast density are both breast cancer risk factors but are negatively correlated. Therefore, we wanted to obtain more insight into this apparent paradox. We investigated in a longitudinal study how weight change over menopause is related to changes in...