Breast Cancer Research (Online Edition)

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  1. Breast cancer is a promising target for vaccination using cancer-testis antigens known to elicit immune responses.

    Breast Cancer Research (Online Edition) 9(4):R46 (2007) PMID 17650306 PMCID PMC2206722

    Cancer-testis antigens (CTAGs) are expressed solely in germ cells and in malignant tissues. They are targets of immune responses mediated by cytotoxic T cells in some cancers, and there is much interest in developing vaccines that induce these responses. The purpose of the present study was to a...
  2. Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression.

    Breast Cancer Research (Online Edition) 9(4):212 (2007) PMID 17705880 PMCID PMC2206719

    Recent insights into the molecular and cellular mechanisms underlying cancer development have revealed that immune cells functionally regulate epithelial cancer development and progression. Moreover, accumulated clinical and experimental data indicate that the outcome of an immune response towar...
  3. 1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice.

    Breast Cancer Research (Online Edition) 9(4):R56 (2007) PMID 17764562 PMCID PMC2206732

    1,1-Bis (3'-indolyl)-1-(p-biphenyl) methane (CDIM9) has been identified as a new peroxisome proliferator-activated receptor (PPAR)-gamma agonist that exhibits both receptor dependent and independent antitumor activities. CDIM9 has not previously been studied with respect to its effects against b...
  4. Characterization of a negative transcriptional element in the BRCA1 promoter.

    Breast Cancer Research (Online Edition) 9(4):R49 (2007) PMID 17663789 PMCID PMC2206725

    Decreased transcription of the BRCA1 gene has previously been observed to occur in sporadic breast tumours, making elucidation of the mechanisms regulating the expression of this gene important for our understanding of the etiology of the disease. Transcriptional elements involved in the regulat...
  5. Application of the multicellular tumour spheroid model to screen PET tracers for analysis of early response of chemotherapy in breast cancer.

    Breast Cancer Research (Online Edition) 9(4):R45 (2007) PMID 17659092 PMCID PMC2206720

    Positron emission tomography (PET) is suggested for early monitoring of treatment response, assuming that effective anticancer treatment induces metabolic changes that precede morphology alterations and changes in growth. The aim of this study was to introduce multicellular tumour spheroids (MTS...
  6. Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage.

    Breast Cancer Research (Online Edition) 9(4):304 (2007) PMID 17659070 PMCID PMC2206713

    Estrogen-mediated proliferation is fundamental to normal mammary gland development. Recent studies have demonstrated that amphiregulin is a critical paracrine regulator of estrogen action during ductal morphogenesis. These studies implicate a critical role for amphiregulin in mammary stem cell d...
  7. The effect of psychosocial factors on breast cancer outcome: a systematic review.

    Breast Cancer Research (Online Edition) 9(4):R44 (2007) PMID 17640330 PMCID PMC2206717

    We sought to review the available evidence regarding the effect of psychosocial factors on the survival of breast cancer patients. We systematically searched the PubMed and PsycINFO databases to identify relevant studies. We identified 31 studies examining the association of various psychosocial...
  8. Inflammation and breast cancer. Inflammatory component of mammary carcinogenesis in ErbB2 transgenic mice.

    Breast Cancer Research (Online Edition) 9(4):211 (2007) PMID 17705881 PMCID PMC2206718

    This review addresses genes differentially expressed in the mammary gland transcriptome during the progression of mammary carcinogenesis in BALB/c mice that are transgenic for the rat neu (ERBB2, or HER-2/neu) oncogene (BALB-neuT664V-E mice). The Ingenuity knowledge database was used to characte...
  9. The effect of versican G3 domain on local breast cancer invasiveness and bony metastasis.

    Breast Cancer Research (Online Edition) 9(4):R47 (2007) PMID 17662123 PMCID PMC2206723

    Increased versican expression has been associated with local breast cancer invasiveness and a more aggressive tumor phenotype. The cellular mechanisms are not fully understood and this study evaluated versican G3 domain with its EGF-like motifs in influencing tumor invasion and metastasis. One r...
  10. Amping up estrogen receptors in breast cancer.

    Breast Cancer Research (Online Edition) 9(4):305 (2007) PMID 17705882 PMCID PMC2206721

    This article highlights a recent study by Holst et al. in Nature Genetics that finds estrogen receptor-alpha (ER-alpha) amplification in early benign lesions and more advanced invasive carcinomas of the breast, and discusses the potential implications to our present understanding of the role of ...
  11. GnRH and LHR gene variants predict adverse outcome in premenopausal breast cancer patients.

    Breast Cancer Research (Online Edition) 9(4):R51 (2007) PMID 17692113 PMCID PMC2206727

    Breast cancer development and progression are dependent on estrogen activity. In premenopausal women, estrogen production is mainly regulated through the hypothalamic-pituitary-gonadal (HPG) axis. We have investigated the prognostic significance of two variants of genes involved in the HPG-axis,...
  12. Adenovirus type 5 E1A-induced apoptosis in COX-2-overexpressing breast cancer cells.

    Breast Cancer Research (Online Edition) 9(4):R41 (2007) PMID 17612393 PMCID PMC2206712

    Suppression of Bcl-2 expression can overcome cellular resistance to apoptosis induced by the adenovirus type 5 gene E1A in models of ovarian and breast cancer. Celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, is known to downregulate Bcl-2 expression. We hypothesized that celecoxib would enhance...
  13. Decline in breast cancer incidence due to removal of promoter: combination estrogen plus progestin.

    Breast Cancer Research (Online Edition) 9(4):108 (2007) PMID 17666116 PMCID PMC2206710

    Combination estrogen plus progestin causes breast cancer. In light of this causal relation, the rapid decline in breast cancer incidence noted in 2003, following an earlier and slower reduction in incidence from 1999, raises important issues regarding the proportion of this decline that may be d...
  14. Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis.

    Breast Cancer Research (Online Edition) 9(4):R42 (2007) PMID 17626637 PMCID PMC2206715

    Int6 has been shown to be an interactive participant with the protein translation initiation complex eIF3, the COP9 signalosome and the regulatory lid of the 26S proteasome. Insertion of mouse mammary tumor virus into the Int6 locus creates a C-terminally truncated form of the protein. Expressio...
  15. No relationship between circulating levels of sex steroids and mammographic breast density: the Prospect-EPIC cohort.

    Breast Cancer Research (Online Edition) 9(4):R53 (2007) PMID 17692133 PMCID PMC2206729

    High breast density is associated with increased breast cancer risk. Epidemiologic studies have shown an increase in breast cancer risk in postmenopausal women with high levels of sex steroids. Hence, sex steroids may increase postmenopausal breast cancer risk via an increase of breast density. ...
  16. The zinc finger domain of Wilms' tumor 1 suppressor gene (WT1) behaves as a dominant negative, leading to abrogation of WT1 oncogenic potential in breast cancer cells.

    Breast Cancer Research (Online Edition) 9(4):R43 (2007) PMID 17634147 PMCID PMC2206716

    There is growing evidence that the Wilms' tumor 1 suppressor gene (WT1) behaves as an oncogene in some forms of breast cancer. Previous studies have demonstrated that the N-terminal domain of WT1 can act as a dominant negative through self-association. In the studies presented here we have explo...
  17. BCoR-L1 variation and breast cancer.

    Breast Cancer Research (Online Edition) 9(4):R54 (2007) PMID 17697391 PMCID PMC2206730

    BRCA1 is involved in numerous essential processes in the cell, and the effects of BRCA1 dysfunction in breast cancer carcinogenesis are well described. Many of the breast cancer susceptibility genes such as BRCA2, p53, ATM, CHEK2, and BRIP1 encode proteins that interact with BRCA1. BCL6 corepres...
  18. Accuracy of computed tomography perfusion in assessing metastatic involvement of enlarged axillary lymph nodes in patients with breast cancer.

    Breast Cancer Research (Online Edition) 9(4):R40 (2007) PMID 17615058 PMCID PMC2206711

    The purpose of this study was to evaluate the diagnostic accuracy of computed tomography (CT) perfusion in differentiating metastatic from inflammatory enlarged axillary lymph nodes in patients with breast cancer. Twenty-five patients with 26 locally advanced breast tumors and clinically palpabl...
  19. Correlation between CpG methylation profiles and hormone receptor status in breast cancers.

    Breast Cancer Research (Online Edition) 9(4):R57 (2007) PMID 17764565 PMCID PMC2206733

    Aberrant DNA methylation has been found frequently in human breast cancers, associated with the loss of expression of a number of regulatory genes for growth and correlated to clinical outcomes. The present study was undertaken to determine whether methylation of a set of growth-suppressor genes...
  20. Analysis of the cellular centrosome in fine-needle aspirations of the breast.

    Breast Cancer Research (Online Edition) 9(4):R48 (2007) PMID 17662154 PMCID PMC2206724

    The purpose of the present investigation is to determine whether centrosome amplifications are present in breast tumor cells, whether there are differences of centrosome amplification between benign breast lesions and breast carcinomas, and whether centrosomal analysis can be of value in the dia...