Expert Opinion on Therapeutic Targets
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An overview of the mTOR pathway as a target in cancer therapy
The mammalian target of rapamycin (mTOR) signaling cascade is a key regulatory pathway controlling initiation of mRNA translation in mammalian cells. The mTOR inhibitor rapamycin and its derivatives have shown potent antineoplastic activities in many preclinical models and clinical trials. First-gen...
Effect of Sanguisorba officinalis L on breast cancer growth and angiogenesis.
SA might be of value as a breast cancer preventive and therapeutic agent by inducing apoptosis and inhibiting angiogenesis. Further research is needed to evaluate its metabolism and synergistic effects with chemotherapeutic drugs....
Osteopontin: a potentially important therapeutic target in cancer.
Introduction: Cancer is an extremely complex disease and most cancer treatments are limited to chemotherapy, radiation and surgery. The progression of tumours towards malignancy requires the interaction of various cytokines, growth factors, transcription factors and effector molecule...
Leptin as a potential therapeutic target for breast cancer prevention and treatment.
We highlight important aspects of leptin in relationship to mammary/breast tumor development. This includes findings from human, in vitro and animal studies. Information on leptin-related compounds which may have therapeutic use is presented. Additionally strategies to alter serum leptin levels by d...
Therapeutic targets for new therapy for corticosteroid refractory asthma.
Corticosteroid-refractory asthma is a heterogeneous disease and can be controlled by add-on treatment of corticosteroid-sparing agents or effective new drugs based on individual abnormalities. The elucidation of the cause of the relative lack of corticosteroid response in this subgroup of asthmatic...
Correlation of antioxidants with lipid peroxidation and lipid profile in patients suffering from coronary artery disease.
In addition to many traditional risk factors for coronary artery disease (CAD) development, enhanced oxidative stress and inflammation are serious conditions that may also be classified as novel risk factors. The objective of the present study was to ascertain the correlation of antioxidants (supero...
Therapeutic targets for Alzheimer's disease.
'Translation' of recent discoveries into disease-modifying therapies has not yet been accomplished. The future will show whether the current drug discovery and development 'pipelines' of pharmaceutical companies yield efficacious new medicines for AD....
Nephroprotective and clinical potential of statins in dialyzed patients
BACKGROUND: The combination of increased cardiovascular mortality and vascular complications due to dyslipidaemia in chronic kidney disease (CKD) has focused attention onto the potential beneficial effects of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) inhibitors (statins) on the cours...
Targeting the extracellular signature of metastatic colorectal cancers.
Studies aimed at the discovery of molecular signatures of cancers and metastasis are ongoing; the future of cancer/metastasis targeting is nanoparticle-mediated drug delivery....
The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function.
pRB is required for adipose conversion and also involved in determining its mitochondrial capacity. p53 inhibits adipogenesis and results suggest that it is involved in maintaining function of adipose tissue....