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- Rcgp, Ingenta, and Wiley from 1996
Nitric oxide, S-Nitrosation, and endothelial permeability.
We discuss evidence for translocation of eNOS, via caveolae, to the cytosol and analyze the significance of eNOS location for S-Nitrosation and onset of endothelial hyperpermeability to macromolecules. © 2013 IUBMB Life, 65(10):819-826, 2013. © 2013 International Union of Biochemistry and Molecular...
Affinity of a galactose-specific legume lectin from Dolichos lablab to adenine revealed by X-ray cystallography.
We present the structure of the galactose-binding D. lablab lectin at different pH values in the native form and in complex with galactose and adenine. This first structure report on this lectin also provides a high resolution atomic view of legume lectin-adenine interactions. The tetramer has two c...
Cover Images IUBMB Life 65 No: 4 April 2013.
MiR-17-5p targets TP53INP1 and regulates cell proliferation and apoptosis of cervical cancer cells.
We identified TP53INP1 as a target of miR-17-5p. miR-17-5p suppressed cell growth and promoted apoptosis of cervical cancer cells, whereas the effects of TP53INP1 were opposite, and ectopic expression of TP53INP1 counteracted the suppression of cell growth caused by miR-17-5p. The same correlations...
Role of disorder in IκB-NFκB interaction.
The paradigmatic transcription factors of the NFκB family provide an increasingly complex view of the mechanism of signal-mediated transcriptional activation. Although the primary event, phosphorylation and subsequent ubiquitin-dependent degradation of IκBα, the inhibitor of the canonical NFκB (p50/...
Interactions via intrinsically disordered regions: what kind of motifs?
We review models explaining the recognition mechanisms of ID proteins. Motif-based interactions are central to all proposed scenarios, including prestructured elements, anchoring sites and linear motifs. We aim to extract consensus features of the models, which could be used to predict ID-binding si...
Do clinical and experimental investigations support an antiatherogenic role for dietary phytosterols/stanols?
The plasma cholesterol-reducing effect of phytosterols (PS) has been recognized in several studies, but the usefulness of PS in preventing coronary heart disease remains controversial, as some investigations claim that the high PS concentrations found in plasma and specific tissues a...
A new function for the calcineurin b subunit: antiplatelet aggregation and anticoagulation.
We report that the recombinant human calcineurin B subunit (CnB) can bind to rabbit platelets and show an antiplatelet aggregation activity. Furthermore, CnB exerts an anticoagulant effect by prolonging the activated partial thromboplastin time and thrombin time and reducing the plasma fibrinogen co...
Signaling epigenetics: novel insights on cell signaling and epigenetic regulation.
We present some examples of the relationship between chromatin-associated proteins and important signal transduction pathways during critical processes like development, differentiation, and disease. There is a great diversity of epigenetic mechanisms that have unexpected interactions with signaling...
Ligand migration in the truncated hemoglobin of Mycobacterium tuberculosis.
The truncated hemoglobin of Mycobacterium tuberculosis (Mt-trHbO) is a small heme protein belonging to the hemoglobin superfamily. Truncated hemoglobins (trHbs) are believed to have functional roles such as terminal oxidases and oxygen sensors involved in the response to oxidative an...