Best Practice & Research Clinical Rheumatology
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The epidemiology of osteoarthritis.
Osteoarthritis (OA) is a leading cause of disability and its incidence is rising due to increasing obesity and an ageing population. Risk factors can be divided into person-level factors, such as age, sex, obesity, genetics, race/ethnicity and diet, and joint-level factors including injury, malalign...
Principles of osteoporotic fracture treatment.
The number of osteoporotic fractures is still increasing and the overall management of these multimorbid patients is demanding. Surgical management of these fractures is challenging due to often comminuted fractures and poor purchase of implants. New implants and some with add-on possibilities such...
Management of infection in systemic lupus erythematosus.
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterised by abnormal autoantibody production and clearance. This immunological background has been suggested to play a role in the susceptibility of SLE patients to infection. Moreover, drugs (most of them immunosuppressive or...
Cutaneous lupus erythematosus: diagnosis and treatment.
We discuss issues in classification and diagnosis of the various sub-types of CLE, as well as provide an update on therapeutic management. Published by Elsevier Ltd....
How to perform local soft-tissue glucocorticoid injections?
Inflammation of periarticular soft-tissue structures such as tendons, tendon sheaths, entheses, bursae, ligaments and fasciae is the hallmark of many inflammatory rheumatic diseases, but inflammation or rather irritation of these structures also occurs in the absence of an underlying rheumatic disea...
Tai Chi and yoga as complementary therapies in rheumatologic conditions.
Tai Chi and yoga are complementary therapies which have, during the last few decades, emerged as popular treatments for rheumatologic and musculoskeletal diseases. This review covers the evidence of Tai Chi and yoga in the management of rheumatologic diseases, especially osteoarthrit...
The role of patient organisations in musculoskeletal care.
We suggest that their work could be divided into three different fields of activities, that is, member benefits to satisfy individual needs, raised awareness to create better conditions for people with disability and the promotion of research to improve prevention, care and find a definite cure. Som...
Precipitating and perpetuating factors of rheumatoid arthritis immunopathology: linking the triad of genetic predisposition, environmental r...
We will summarise the risk factors for RA development that have currently been identified, outlining the specific gene-environment and gene-gene interactions that may occur to precipitate and perpetuate autoimmunity and RA. We will also focus on how this knowledge of risk factors for RA may be imple...
Quality of life and the outcome of established rheumatoid arthritis.
Rheumatoid arthritis (RA) is a long-term condition causing joint pain and swelling and sometimes systemic involvement. The aims of treatment are, first, to reduce the impact the disease has on a patient and, second, to halt progression of disease. The advent of intensive therapy, inc...
Clinimetric evaluations of patients with chronic widespread pain.
Assessing chronic widespread pain (CWP) and its impact on physical, emotional and social function requires multidimensional qualitative and health-related quality of life (HRQL) instruments. The recommendations of the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPAC...