Journal of Toxicology and Environmental Health, Part A: Current Issues

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  1. The impact of water pollution on fish species in southeast region of Goiás, Brazil.

    Journal of Toxicology and Environmental Health,... 79(1):8 (2016) PMID 26699803

    The rivers from the region of Catalão, Southeast Goiás State, Brazil, are exposed to intense anthropogenic influences including agricultural activities, industry, and urban waste. The aim of this study was to determine the severity of water pollution by conducting an experiment involving in situ...
  2. Evaluation of lignan (-)-cubebin extracted from Piper cubeba on human colon adenocarcinoma cells (HT29).

    Journal of Toxicology and Environmental Health,... 79(2):92 (2016) PMID 26817788

    The dibenzylbutyrolactone lignan (-)-cubebin, which is extracted from the seeds of the pepper Piper cubeba, has shown promise as an anti-inflammatory, analgesic, leishmanicidal, antiproliferative, and trypanocidal compound. Given the therapeutic potential of (-)-cubebin, this study aimed to inve...
  3. Assessing differences in toxicity and teratogenicity of three phthalates, Diethyl phthalate, Di-n-propyl phthalate, and Di-n-butyl phthalate, using Xenopus laevis embryos.

    Journal of Toxicology and Environmental Health,... 79(2):71 (2016) PMID 26730679

    Phthalates, compounds used to add flexibility to plastics, are ubiquitous in the environment. In particular, the diethyl (DEP), di-n-propyl (DnPP), and di-n-butyl (DBP) phthalates were found to exert detrimental effects in both mammalian and non-mammalian studies, with toxic effects varying acco...
  4. Essential and toxic elements in seaweeds for human consumption.

    Journal of Toxicology and Environmental Health,... 79(3):112 (2016) PMID 26817952

    Essential elements (K, Ca, P, S, Cl, Mn, Fe, Cu, Zn, Ni, Br, and I) and nonessential or toxic elements (Al, Ti, Si, Rb, Sr, As, Cd, Sn, and Pb) were determined by energy-dispersive polarized x-ray fluorescence spectrometry in 14 seaweeds purchased in local specialty stores in Italy and consumed ...
  5. Increases in ambient particulate matter air pollution, acute changes in platelet function, and effect modification by aspirin and omega-3 fatty acids: A panel study.

    Journal of Toxicology and Environmental Health,... 79(6):287 (2016) PMID 27029326

    Increased particulate matter (PM) air pollutant concentrations have been associated with platelet activation. It was postulated that elevated air pollutant concentrations would be associated with increases in measures of platelet function and that responses would be blunted when taking aspirin a...
  6. Taxonomic applicability of inflammatory cytokines in adverse outcome pathway (AOP) development.

    Journal of Toxicology and Environmental Health,... 79(4):184 (2016) PMID 26914248

    Cytokines, low-molecular-weight messenger proteins that act as intercellular immunomodulatory signals, have become a mainstream preclinical marker for assessing the systemic inflammatory response to external stressors. The challenge is to quantitate from healthy subjects cytokine levels that are...
  7. Modifications of carbon black nanoparticle surfaces modulate type II pneumocyte homoeostasis.

    Journal of Toxicology and Environmental Health,... 79(4):153 (2016) PMID 26914170

    Inhalation uptake of carbon black nanoparticles (CBNP) bears the risk of morphological and functional lung impairment attributed to the highly reactive particle surface area. Chemical particle surface modifications might affect particle-cell interactions; however, thus far these alterations have...
  8. Modulation of hexavalent chromium-induced genotoxic damage in peripheral blood of mice by epigallocatechin-3-gallate (EGCG) and its relationship to the apoptotic activity.

    Journal of Toxicology and Environmental Health,... 79(1):28 (2016) PMID 26713419

    This study was conducted to investigate the relationship between modulation of genotoxic damage and apoptotic activity in Hsd:ICR male mice treated with (-)-epigallocatechin-3-gallate (EGCG) and hexavalent chromium [Cr(VI)]. Four groups of 5 mice each were treated with (i) control vehicle only, ...
  9. Impaired brain StAR and HSP70 gene expression in zebrafish exposed to Methyl-Parathion based insecticide.

    Journal of Toxicology and Environmental Health,... 79(1):1 (2016) PMID 26699931

    Fish production ponds and natural water body areas located in close proximity to agricultural fields receive water with variable amounts of agrochemicals, and consequently, compounds that produce adverse effects may reach nontarget organisms. The aim of this study was to investigate whether wate...
  10. Effect of temperature on oxidative stress parameters and enzyme activity in tissues of Cape River crab (Potamanautes perlatus) following exposure to silver nanoparticles (AgNP).

    Journal of Toxicology and Environmental Health,... 79(2):61 (2016) PMID 26730549

    Biomarkers of oxidative stress have been widely used in environmental assessments to evaluate the effects of exposure of aquatic organisms to contaminants from various anthropogenic sources. Silver nanoparticles (AgNP), the most produced NP worldwide and used in several consumer products, are kn...
  11. Long-term toxicity of naturally occurring asbestos in male Fischer 344 rats.

    Journal of Toxicology and Environmental Health,... 79(2):49 (2016) PMID 26818398

    Naturally occurring asbestos (NOA) fibers are found in geologic deposits that may be disturbed by mining, earthworks, or natural processes, resulting in adverse health risks to exposed individuals. The toxicities of Libby amphibole and NOA samples including Sumas Mountain chrysotile (SM), El Dor...
  12. Iron signature in asbestos-induced malignant pleural mesothelioma: A population-based autopsy study.

    Journal of Toxicology and Environmental Health,... 79(3):129 (2016) PMID 26818092

    Malignant pleural mesothelioma (MPM) is an aggressive cancer with poor prognosis. The development of MPM is frequently linked to inhalation of asbestos fibers. A genetic component of susceptibility to this disease is suggested by the observation that some individuals develop MPM following lower ...
  13. Long-term daily vibration exposure alters current perception threshold (CPT) sensitivity and myelinated axons in a rat-tail model of vibration-induced injury.

    Journal of Toxicology and Environmental Health,... 79(3):101 (2016) PMID 26852665

    Repeated exposure to hand-transmitted vibration through the use of powered hand tools may result in pain and progressive reductions in tactile sensitivity. The goal of the present study was to use an established animal model of vibration-induced injury to characterize changes in sensory nerve fu...
  14. Current sources of lead exposure and their relative contributions to the blood lead levels in the general adult population of Northern France: The IMEPOGE Study, 2008-2010.

    Journal of Toxicology and Environmental Health,... 79(6):245 (2016) PMID 27074096

    There is justification for limiting lead (Pb) exposure as much as possible, given its impact on health at low concentrations. Consequently, the aim of this study was to measure blood lead levels (BLL) and examine exposure factors related to BLL variations in the general adult population of north...
  15. In utero and lactational exposure to fipronil in female rats: Pregnancy outcomes and sexual development.

    Journal of Toxicology and Environmental Health,... 79(6):266 (2016) PMID 27074097

    Fipronil, a phenylpyrazole insecticide, is used in agriculture, veterinary medicine, and public health. Because this insecticide is considered a potential endocrine disruptor, the aim of this study was to examine the influence of perinatal exposure to fipronil on neonatal female reproductive sys...
  16. Metals and metalloid in eight fish species consumed by citizens of Bogota D.C., Colombia, and potential risk to humans.

    Journal of Toxicology and Environmental Health,... 79(5):232 (2016) PMID 27010256

    The risk imposed upon society by consumption of foods contaminated with metals and metalloids is an environmental problem attributed to the increasing number of mining extraction activities currently underway in Colombia. The aim of the current study was to determine concentrations of mercury (H...
  17. Predicting oral relative bioavailability of arsenic in soil from in vitro bioaccessibility.

    Journal of Toxicology and Environmental Health,... 79(4):165 (2016) PMID 27029599

    Several investigations have been conducted to develop in vitro bioaccessibility (IVBA) assays that reliably predict in vivo oral relative bioavailability (RBA) of arsenic (As). This study describes a meta-regression model relating soil As RBA and IVBA that is based upon data combined from previo...
  18. Single and combined effects of air pollutants on circulatory and respiratory system-related mortality in Belgrade, Serbia.

    Journal of Toxicology and Environmental Health,... 79(1):17 (2016) PMID 26699658

    The aim of this study was to investigate the association between short- and long-term exposure to particulate matter (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), and soot and mortality attributed to circulatory and respiratory diseases in Belgrade area (Serbia). The analyzed data set co...
  19. In vivo dermal absorption of pyrethroid pesticides in the rat.

    Journal of Toxicology and Environmental Health,... 79(2):83 (2016) PMID 26817658

    Exposure to pyrethroid pesticides is a potential cause for concern. The objective of this study was to examine the in vivo dermal absorption of bifenthrin, deltamethrin, and permethrin in the rat. Dorsal hair on adult male Long-Evans rats was removed. The next day, the skin was dosed with 1750 n...
  20. Molecular and structural changes induced by essential oils treatments in Vicia faba roots detected by genotoxicity testing.

    Journal of Toxicology and Environmental Health,... 79(4):143 (2016) PMID 26914511

    Over the last few years, there has been an increased interest in exploiting allelopathy in organic agriculture. The aim of this investigation was to examine the effects of essential oil mixtures in order to establish their allelopathic use in agriculture. Two mixtures of essential oils consistin...