Journal of Toxicology and Environmental Health, Part A: Current Issues

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  1. Taxonomic applicability of inflammatory cytokines in adverse outcome pathway (AOP) development.

    Journal of Toxicology and Environmental Health,... 79(4):184 (2016) PMID 26914248

    Cytokines, low-molecular-weight messenger proteins that act as intercellular immunomodulatory signals, have become a mainstream preclinical marker for assessing the systemic inflammatory response to external stressors. The challenge is to quantitate from healthy subjects cytokine levels that are...
  2. Modifications of carbon black nanoparticle surfaces modulate type II pneumocyte homoeostasis.

    Journal of Toxicology and Environmental Health,... 79(4):153 (2016) PMID 26914170

    Inhalation uptake of carbon black nanoparticles (CBNP) bears the risk of morphological and functional lung impairment attributed to the highly reactive particle surface area. Chemical particle surface modifications might affect particle-cell interactions; however, thus far these alterations have...
  3. Different effects of long-term exposures to SO2 and NO2 air pollutants on asthma severity in young adults.

    Journal of Toxicology and Environmental Health,... 79(8):342 (2016) PMID 27092440

    Numerous studies demonstrated that exposure to ambient air pollutants contributes to severity and frequency of asthma exacerbations. However, whether common air pollutants, such as nitrogen dioxide (NO2) and sulfur dioxide (SO2), exert differential effects on asthma occurrence and severity is un...
  4. Analysis of the miRNA-mRNA networks in malignant transformation BEAS-2B cells induced by alpha-particles.

    Journal of Toxicology and Environmental Health,... 79(9-10):427 (2016) PMID 27267825

    The aim of this study was to determine the toxicity induced by irradiation with alpha-particles on malignant transformation of immortalized human bronchial epithelial cells (BEAS-2B) using miRNA-mRNA networks. The expression of BEAS-2B cells was determined by measuring colony formation, mtDNA, m...
  5. The characteristics of emergency department presentations related to acute herbicide or insecticide poisoning in South Korea between 2011 and 2014.

    Journal of Toxicology and Environmental Health,... 79(11):466 (2016) PMID 27267557

    The aim of this study was to examine epidemiologic data regarding acute herbicide or insecticide poisoning in adults from 2011 to 2014 at the national level in South Korea. Further, the association between governmental regulations involving pesticides and changes in pesticide poisoning occurrenc...
  6. Role of astrocyte activation in fine particulate matter-enhancement of existing ischemic stroke in Sprague-Dawley male rats.

    Journal of Toxicology and Environmental Health,... 79(9-10):393 (2016) PMID 27267821

    Exposure to particulate matter (PM) with an aerodynamic diameter of less than 2.5 μm (PM2.5) is associated with increased risk of ischemic stroke, but potential neurotoxic mechanisms remain to be determined. In this study, adult male Sprague- Dawley (SD) rats were divided into four groups as fol...
  7. Impacts of prenatal nanomaterial exposure on male adult Sprague-Dawley rat behavior and cognition.

    Journal of Toxicology and Environmental Health,... 79(11):447 (2016) PMID 27092594 PMCID PMC4899177

    It is generally accepted that gestational xenobiotic exposures result in systemic consequences in the adult F1 generation. However, data on detailed behavioral and cognitive consequences remain limited. Using our whole-body nanoparticle inhalation facility, pregnant Sprague-Dawley rats (gestatio...
  8. Long-term toxicity of naturally occurring asbestos in male Fischer 344 rats.

    Journal of Toxicology and Environmental Health,... 79(2):49 (2016) PMID 26818398

    Naturally occurring asbestos (NOA) fibers are found in geologic deposits that may be disturbed by mining, earthworks, or natural processes, resulting in adverse health risks to exposed individuals. The toxicities of Libby amphibole and NOA samples including Sumas Mountain chrysotile (SM), El Dor...
  9. In vivo dermal absorption of pyrethroid pesticides in the rat.

    Journal of Toxicology and Environmental Health,... 79(2):83 (2016) PMID 26817658

    Exposure to pyrethroid pesticides is a potential cause for concern. The objective of this study was to examine the in vivo dermal absorption of bifenthrin, deltamethrin, and permethrin in the rat. Dorsal hair on adult male Long-Evans rats was removed. The next day, the skin was dosed with 1750 n...
  10. Xeroderma pigmentosum, complementation group D expression in H1299 lung cancer cells following benzo[a]pyrene exposure as well as in head and neck cancer patients.

    Journal of Toxicology and Environmental Health,... 79(1):39 (2016) PMID 26731659

    DNA repair genes play critical roles in response to carcinogen-induced and anticancer therapy-induced DNA damage. Benzo[a]pyrene (BaP), the most carcinogenic polycyclic aromatic hydrocarbon (PAH), is classified as a group 1 carcinogen by International Agency for Research on Cancer. The aims of t...
  11. Air pollution exposure and daily clinical visits for allergic rhinitis in a subtropical city: Taipei, Taiwan.

    Journal of Toxicology and Environmental Health,... 79(12):494 (2016) PMID 27294298

    This study was undertaken to determine whether there was an association between air pollutant level exposure and daily clinic visits for allergic rhinitis (AR) in Taipei, Taiwan. Daily clinic visits for AR and ambient air pollution data for Taipei were obtained for the period of 2006-2011. The r...
  12. Effect of temperature on oxidative stress parameters and enzyme activity in tissues of Cape River crab (Potamanautes perlatus) following exposure to silver nanoparticles (AgNP).

    Journal of Toxicology and Environmental Health,... 79(2):61 (2016) PMID 26730549

    Biomarkers of oxidative stress have been widely used in environmental assessments to evaluate the effects of exposure of aquatic organisms to contaminants from various anthropogenic sources. Silver nanoparticles (AgNP), the most produced NP worldwide and used in several consumer products, are kn...
  13. Modulation of hexavalent chromium-induced genotoxic damage in peripheral blood of mice by epigallocatechin-3-gallate (EGCG) and its relationship to the apoptotic activity.

    Journal of Toxicology and Environmental Health,... 79(1):28 (2016) PMID 26713419

    This study was conducted to investigate the relationship between modulation of genotoxic damage and apoptotic activity in Hsd:ICR male mice treated with (-)-epigallocatechin-3-gallate (EGCG) and hexavalent chromium [Cr(VI)]. Four groups of 5 mice each were treated with (i) control vehicle only, ...
  14. Single and combined effects of air pollutants on circulatory and respiratory system-related mortality in Belgrade, Serbia.

    Journal of Toxicology and Environmental Health,... 79(1):17 (2016) PMID 26699658

    The aim of this study was to investigate the association between short- and long-term exposure to particulate matter (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), and soot and mortality attributed to circulatory and respiratory diseases in Belgrade area (Serbia). The analyzed data set co...
  15. Impaired brain StAR and HSP70 gene expression in zebrafish exposed to Methyl-Parathion based insecticide.

    Journal of Toxicology and Environmental Health,... 79(1):1 (2016) PMID 26699931

    Fish production ponds and natural water body areas located in close proximity to agricultural fields receive water with variable amounts of agrochemicals, and consequently, compounds that produce adverse effects may reach nontarget organisms. The aim of this study was to investigate whether wate...
  16. Involvement of hypoxia-inducible factor-1 α (HIF-1α) in inhibition of benzene on mouse hematopoietic system.

    Journal of Toxicology and Environmental Health,... 79(9-10):402 (2016) PMID 27267822

    Benzene is an occupational and environmental pollutant that damages the hematopoietic system through oxidant mechanisms. The aims of this study were to assess the role of oxidation in benzene-mediated damage by determination of the levels of reactive oxygen species (ROS) and to evaluate the role...
  17. Iron signature in asbestos-induced malignant pleural mesothelioma: A population-based autopsy study.

    Journal of Toxicology and Environmental Health,... 79(3):129 (2016) PMID 26818092

    Malignant pleural mesothelioma (MPM) is an aggressive cancer with poor prognosis. The development of MPM is frequently linked to inhalation of asbestos fibers. A genetic component of susceptibility to this disease is suggested by the observation that some individuals develop MPM following lower ...
  18. In utero and lactational exposure to fipronil in female rats: Pregnancy outcomes and sexual development.

    Journal of Toxicology and Environmental Health,... 79(6):266 (2016) PMID 27074097

    Fipronil, a phenylpyrazole insecticide, is used in agriculture, veterinary medicine, and public health. Because this insecticide is considered a potential endocrine disruptor, the aim of this study was to examine the influence of perinatal exposure to fipronil on neonatal female reproductive sys...
  19. Seed coating with arbuscular mycorrhizal fungi as an ecotechnologicalapproach for sustainable agricultural production of common wheat (Triticum aestivum L.).

    Journal of Toxicology and Environmental Health,... 79(7):329 (2016) PMID 27077274

    The exploitation of arbuscular mycorrhizal (AM) fungi has become of great interest in agriculture due to their potential roles in reducing the need for agrochemicals, while improving plant growth and nutrition. Nevertheless, the application of AM fungi by dispersing inocula in granular form to o...
  20. Arbuscular mycorrhizal fungi are an alternative to the application of chemical fertilizer in the production of the medicinal and aromatic plant Coriandrum sativum L.

    Journal of Toxicology and Environmental Health,... 79(7):320 (2016) PMID 27077563

    The widespread use of agrochemicals is detrimental to the environment and may exert harmful effects on human health. The consumer demand for organic food plants has been increasing. There is thus a rising need for alternatives to agrochemicals that can foster sustainable plant production. The ai...