Molecular & Cellular Proteomics
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- Rupress, Endocrine, Csh, American Society for Biochemistry and Molecular Biology, Proquest, Highwire from 2002, Aacr, Ama, Aaas, Nephrology, and CSA
Regulation of Protein Degradation by O-GlcNAcylation: Crosstalk with Ubiquitination.
We summarize the current knowledge of the interplay between O-GlcNAcylation and ubiquitination in the control of protein degradation. Understanding the mechanisms of action of O-GlcNAcylation in the ubiquitin-proteosome system shall facilitate the development of therapeutics for human diseases such...
Identification of Lysine Succinylation Substrates and the Succinylation Regulatory Enzyme CobB in Escherichia coli.
We report the identification of 2,580 bacterial lysine succinylation sites in 670 proteins and 2,803 lysine acetylation (Kac) sites in 782 proteins, representing the first lysine succinylation dataset and the largest Kac dataset in wild-type E. coli. We quantified dynamic changes of the lysine succi...
Hypoxic Tumor Cell Modulates Its Microenvironment to Enhance Angiogenic and Metastatic Potential by Secretion of Proteins and Exosomes
Antibodypedia, a portal for sharing antibody and antigen validation data.
We describe a new publicly available portal called Antibodypedia, which has been developed to allow sharing of information regarding validation of antibodies in which providers can submit their own validation results and reliability scores. We report standardized validation criteria and submission r...
Automated online sequential isotope labeling for protein quantitation applied to proteasome tissue-specific diversity.
A novel chromatographic method allows on-line reanalysis of the proteome.
Large scale identification and quantitative profiling of phosphoproteins expressed during seed filling in oilseed rape.
Seed filling is a dynamic, temporally regulated phase of seed development that determines the composition of storage reserves in mature seeds. Although the metabolic pathways responsible for storage reserve synthesis such as carbohydrates, oils, and proteins are known, little is known about their re...
Differential expression of serum clusterin isoforms in colorectal cancer.
We applied proteomic techniques to analyze its isoforms in donors and patients. First we separated serum proteins through concanavalin A, obtaining a fraction with non- and O-glycosylated proteins (FI) and a second fraction enriched in N-glycoproteins (FII) wherein clusterin was supposed to elute on...
High-throughput Analysis of in vivo Protein Stability.
We developed a new method, Stable-seq, which uses a simple genetic selection combined with high-throughput DNA sequencing to assess the in vivo stability of a large number of variants of a protein. The variants are fused to a metabolic enzyme, which here is the yeast Leu2 protein. Plasmids encoding...
Exploration of binary virus-host interactions using an infectious protein complementation assay.
We detected binary interactions between influenza A virus polymerase and host proteins during the course of an actual viral infection, using a new strategy based on trans-complementation of the Gluc1 and Gluc2 fragments of Gaussia princeps luciferase. Infectious recombinant influenza viruses that en...