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Vascular Pharmacology

Print ISSN
1537-1891
Electronic ISSN
1879-3649
Impact factor
2.174
Publisher
Sciencedirect
URL
http://www.sciencedirect.com/science/journal/15371891
Usage rank
4675
Article count
4354
Free count
8
Free percentage
0.00183739
PDFs via platforms
Rcgp, Gale, Sciencedirect, and Ingenta

  1. The effect on ephedrine prodrugs on locomotor activity in rats.

    Vascular Pharmacology 27(1):109 (1996) PMID 8742505

    1. Five oxazolidines were synthesized by reaction of (-) ephedrine with formaldehyde, propionaldehyde, butyraldehyde, isobutyraldehyde, and acetone, respectively. 2. Half-lives of hydrolysis were measured in pH 7.4 aqueous buffer. Half-lives varied from 12 seconds to 11 minutes. 3. The compounds wer...
  2. Activation of liver X receptor enhances the proliferation and migration of endothelial progenitor cells and promotes vascular repair through...

    Vascular Pharmacology 62(3):150 (2014) PMID 24892989

    We demonstrate that LXRs, including LXRα and LXRβ, are expressed and functional in rat bone marrow-derived EPCs. Treatment with an LXR agonist, TO901317 (TO) or GW3965 (GW), significantly increased the proliferation and migration of EPCs, as well as Akt and eNOS phosphorylation in EPCs. Moreover, LX...
  3. Cardiovascular effects of acute treatment with the antipsychotic drug olanzapine in rats.

    Vascular Pharmacology 62(3):143 (2014) PMID 24969105

    We investigated if the atypical antipsychotic olanzapine alters in vivo cardiovascular function in rats. Male Sprague-Dawley rats were prepared with indwelling catheters. After 4 h of recovery from surgery, the mean arterial pressure (MAP), mean circulatory filling pressure (MCFP; index of body veno...
  4. Low anticoagulant heparin blocks thrombin-induced endothelial permeability in a PAR-dependent manner.

    Vascular Pharmacology 62(2):63 (2014) PMID 24469066 PMCID PMC4111793

    We studied the effects of heparin and low anticoagulant 2-O, 3-O desulfated heparin (ODSH) on thrombin-induced increases in paracellular permeability of cultured human pulmonary endothelial cells (ECs). Pretreatment with heparin or ODSH blocked thrombin-induced decrease in the EC transendothelial el...
  5. Nicotinic acetylcholine receptor mediates nicotine-induced actin cytoskeletal remodeling and extracellular matrix degradation by vascular sm...

    Vascular Pharmacology 58(1-2):87 (2013) PMID 22940282 PMCID PMC3530635

    We found that cigarette smoke extract, nicotine, and the cholinergic agonist, carbachol, were similarly effective in inducing the formation of podosome rosettes in A7r5 VSMCs. α-Bungarotoxin and atropine experiments confirmed the involvement of nicotinic acetylcholine receptors (nAChRs). Western blo...
  6. Gleditsioside B, a triterpene saponin isolated from the anomalous fruits of Gleditsia sinensis Lam., abrogates bFGF-induced endothelial cell...

    Vascular Pharmacology 58(1-2):118 (2013) PMID 23026290

    We assessed the effect of GB on endothelial cell migration, a crucial event in angiogenesis, and explored the underlying mechanisms. The migration of endothelial cells was assessed by transwell. The expressions of MMP-2/-9 and TIMP-1/-2 were analyzed by Western blotting, and the activities of MMP-2/...
  7. Crosstalk between macrophages and smooth muscle cells in atherosclerotic vascular diseases.

    Vascular Pharmacology 57(1):24 (2012) PMID 22402259

    Macrophages and smooth muscle cells (SMCs) represent major players in the pathogenesis of atherosclerotic vascular diseases. SMCs often reside in close proximity to macrophage clusters. Activated macrophages may promote pro-atherogenic functions of SMCs. Addressing macrophage-dependent mechanisms of...
  8. Fenofibrate attenuates nicotine-induced vascular endothelial dysfunction in the rat.

    Vascular Pharmacology 55(5-6):163 (2011) PMID 21864717

    The study has been designed to investigate the effect of fenofibrate on nicotine-induced vascular endothelial dysfunction (VED) in rats. Nicotine (2 mg/kg/day, i.p., 4 weeks) was administered to produce VED in rats. The development of VED was assessed by employing isolated aortic ring preparation an...
  9. The annexin A2 system and vascular homeostasis.

    Vascular Pharmacology 54(3-6):59 (2011) PMID 21440088 PMCID PMC3109204

    Optimal fibrin balance requires precisely controlled plasmin generation on the surface of endothelial cells, which line the blood vessel wall. As a co-receptor for plasminogen and tissue plasminogen activator (tPA), which are key factors in plasmin generation, the annexin A2 (A2) complex promotes va...
  10. Anti-angiogenic activity of triptolide in anaplastic thyroid carcinoma is mediated by targeting vascular endothelial and tumor cells

    Vascular Pharmacology 52(1):46 (2010) PMID 19854299

    We further expound the precise mechanism involved in this activity. Triptolide downregulated nuclear factor kappa B (NF-κB) pathway and its targeting genes associated with endothelial cell mobilization in human umbilical vein endothelial cells (HUVECs) and impaired VEGF expression in thyroid carcino...