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Vascular Pharmacology

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  1. Tumor necrosis factor-related apoptosis-inducing ligand in vascular inflammation and atherosclerosis: a protector or culprit?

    Vascular Pharmacology 63(3):135 (2014) PMID 25451562

    We provide a critical review on the potential relationships between TRAIL and atherosclerosis. We propose that increased TRAIL production may also have potential detrimental effects on vascular inflammation and atherosclerosis. Further in vivo experiments are warranted to elucidate the effects of ex...
  2. Cyclooxygenase-2-derived prostanoids reduce inward arterial remodeling induced by blood flow reduction in old obese Zucker rat mesenteric ar...

    Vascular Pharmacology 58(5-6):356 (2013) PMID 23524072

    We investigated mesenteric artery narrowing following blood flow reduction in vivo in 3- and 12-month-old obese Zucker rats. After 21 days, inward remodeling occurred in low flow (LF) arteries in young and old lean rats and in young obese rats (30% diameter reduction). Diameter did not significantly...
  3. Angiostatin inhibits endothelial MMP-2 and MMP-14 expression: a hypoxia specific mechanism of action.

    Vascular Pharmacology 58(4):280 (2013) PMID 23220260

    We investigated the effects of angiostatin on endothelial cell migration and apoptosis during hypoxia. Human microvascular endothelial cells (HMVEC-L) were exposed to angiostatin under normoxic or hypoxic conditions. Apoptosis was measured by flow-cytometry. HMVEC-L migration was studied using a mod...
  4. Propranolol-induced relaxation in the rat basilar artery.

    Vascular Pharmacology 58(4):307 (2013) PMID 23295260

    Propranolol is a non-selective beta-adrenergic receptor blocker used in the treatment of cardiovascular diseases and migraine prophylaxis. Although it has been shown that propranolol dilates the peripheral arteries of rat, its action in the central nervous system vasculature has not been investigate...
  5. Translational cardiovascular research in the quest for new therapies.

    Vascular Pharmacology 58(3):v (2013) PMID 23518399

  6. Gomisin J from Schisandra chinensis induces vascular relaxation via activation of endothelial nitric oxide synthase.

    Vascular Pharmacology 57(2-4):124 (2012) PMID 22728282

    Gomisin J (GJ) is a lignan contained in Schisandra chinensis (SC) which is a well-known medicinal herb for improvement of cardiovascular symptoms in Korean. Thus, the present study examined the vascular effects of GJ, and also determined the mechanisms involved. Exposure of rat thoracic aorta to GJ...
  7. Hexosamine pathway activation and O-linked-N-acetylglucosamine: novel mediators of endothelial dysfunction in hyperglycemia and diabetes.

    Vascular Pharmacology 56(3-4):113 (2012) PMID 22289438

  8. Age-related β-adrenergic receptor-mediated vasorelaxation is changed by altering G protein receptor kinase 2 expression.

    Vascular Pharmacology 55(5-6):178 (2011) PMID 21951806

    We have shown that GRK expression and activity increases with age in Fischer 344 rat aorta. In this study we validated that carotid arteries have similar age-related changes in the β-AR signaling axis as aorta. This finding allowed use of in vivo infection and delivery of two adenovirus vectors to c...
  9. MicroRNA regulation in angiogenesis.

    Vascular Pharmacology 55(4):79 (2011) PMID 21777698

    We aim at describing the role of miRNAs in angiogenesis, focusing, in particular, on post-ischemic neovascularization. First, we will describe the regulation and the expression of miRNAs in endothelial cells. Then, we will analyze the role of miRNAs in reparative and pathological angiogenesis. Final...
  10. Acute DPP-4 inhibition modulates vascular tone through GLP-1 independent pathways.

    Vascular Pharmacology 55(1-3):2 (2011) PMID 21397040

    Evidence from both clinical and experimental studies indicates that Di-peptidyl peptidase-IV (DPP-4) inhibition may mediate favorable effects on the cardiovascular system. The objective of this study was to examine the acute effects of DPP-4 inhibition on vascular responses and to study the underlyi...