Nature Structural & Molecular Biology
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Found in translation.
Tony Pawson 1952-2013.
Polyadenylation site-induced decay of upstream transcripts enforces promoter directionality.
We conclude that asymmetric sequence distribution around human gene promoters serves to provide a directional RNA output from an otherwise bidirectional transcription process....
SIMIBI twins in protein targeting and localization.
We define common mechanistic principles and differences for these SIMIBI proteins....
Activating silent argonautes.
Multiple Argonaute proteins are implicated in gene silencing by RNA interference (RNAi), but only one is known to be an endonuclease that can cleave target mRNAs. Chimeric Argonaute proteins now reveal an unexpected mechanism by which mutations distal to the catalytic center can unmask intrinsic cat...
A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction.
We used macromolecular EM and biochemistry to investigate the subunit organization, structure and Mediator interaction of the Saccharomyces cerevisiae CKM. We found that interaction of the CKM with Mediator's middle module interferes with CTD-dependent RNAPII binding to a previously unknown middle-m...
A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells.
We characterize a previously unidentified PTENpg1-encoded antisense RNA (asRNA), which regulates PTEN transcription and PTEN mRNA stability. We find two PTENpg1 asRNA isoforms, α and β. The α isoform functions in trans, localizes to the PTEN promoter and epigenetically modulates PTEN transcription b...
Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle.
We analyzed the role of the activating co-chaperone Aha1 in the progression of the yeast Hsp90 chaperone cycle and identified a critical ternary Hsp90 complex containing the co-chaperones Aha1 and Cpr6. Aha1 accelerates the intrinsically slow conformational transitions of Hsp90 to an N-terminally as...
Coordinating the impact of structural genomics on the human α-helical transmembrane proteome.