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Journal of Cellular and Molecular Medicine

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  1. PMC, a potent hydrophilic α-tocopherol derivative, inhibits NF-κB activation via PP2A but not IκBα-dependent signals in vascular smooth musc...

    Journal of Cellular and Molecular Medicine 18(7):1278 (2014) PMID 24725826

    We investigated the mechanisms of the inhibitory effects of PMC in vascular smooth muscle cells (VSMCs) exposed to pro-inflammatory stimuli, lipopolysaccharide (LPS) combined with interferon (IFN)-γ. Treatment of LPS/IFN-γ-stimulated VSMCs with PMC suppressed the expression of inducible nitric oxide...
  2. Inhibitory effects of hydrogen sulphide on pulmonary fibrosis in smoking rats via attenuation of oxidative stress and inflammation.

    Journal of Cellular and Molecular Medicine 18(6):1098 (2014) PMID 24629044

    We established a rat model of passive smoking and investigated whether or not H2 S has protective effects against pulmonary fibrosis induced by chronic cigarette smoke exposure. Rat lung tissues were stained with haematoxylin-eosin and Masson's trichrome. The expression of type I collagen was detect...
  3. TAP1 I333V gene polymorphism and type 1 diabetes mellitus: a meta-analysis of 2248 cases.

    Journal of Cellular and Molecular Medicine 18(5):929 (2014) PMID 24655325

    Transporter associated with antigen processing 1 (TAP1) I333V gene polymorphism has been suggested to be associated with type 1 diabetes mellitus (T1DM) susceptibility. However, the results from individual studies are inconsistent. To explore the association of TAP1 I333V gene polymorphisms with T1D...
  4. Verrucous carcinoma of the head and neck - not a human papillomavirus-related tumour?

    Journal of Cellular and Molecular Medicine 18(4):635 (2014) PMID 24350715

    Our aim was to investigate the prevalence of a broad spectrum of HPV in VC of the head and neck using sensitive and specific molecular assays. Formalin-fixed, paraffin-embedded samples of 30 VC and 30 location-matched normal tissue samples were analysed, by using six different polymerase chain react...
  5. Hydrogen sulphide suppresses human atrial fibroblast proliferation and transformation to myofibroblasts.

    Journal of Cellular and Molecular Medicine 17(10):1345 (2013) PMID 23945069

    We hypothesized that H2S inhibits proliferative response of atrial fibroblasts through modulation of potassium channels. Biophysical property of potassium channels in human atrial fibroblasts was examined by whole-cell patch clamp technique and their cellular proliferation in response to H2S was ass...
  6. Foetal defence against cancer: a hypothesis.

    Journal of Cellular and Molecular Medicine 17(9):1096 (2013) PMID 23815673

  7. Palifermin for the protection and regeneration of epithelial tissues following injury: new findings in basic research and pre-clinical model...

    Journal of Cellular and Molecular Medicine 17(9):1065 (2013) PMID 24151975

    We review these studies to provide the pre-clinical background for clinical trials that are described in the accompanying article and the rationale for additional clinical applications of palifermin. © 2013 The Authors. Journal of Cellular and Molecular Medicine Published by Foundation for Cellular...
  8. The sepsis model: an emerging hypothesis for the lethality of inhalation anthrax.

    Journal of Cellular and Molecular Medicine 17(7):914 (2013) PMID 23742651 PMCID PMC3729634

    We propose that death in inhalation anthrax results from an overwhelming bacteraemia that leads to severe sepsis. According to our model, the central role of anthrax toxin is to permit the vegetative bacteria to escape immune detection. Other forms of B. anthracis infection have lower mortality beca...
  9. Akt-mediated anti-apoptotic effects of substance P in Anti-Fas-induced apoptosis of human tenocytes.

    Journal of Cellular and Molecular Medicine 17(6):723 (2013) PMID 23577779

    We show that SP reduces Anti-Fas-induced apoptosis in human tenocytes and that this anti-apoptotic effect of SP is mediated through NK-1 R and Akt-specific pathways. © 2013 The Authors Journal of Cellular and Molecular Medicine Published by Foundation for Cellular and Molecular Medicine/Blackwell Pu...
  10. Identity of tendon stem cells - how much do we know?

    Journal of Cellular and Molecular Medicine 17(1):55 (2013) PMID 23279609

    We called them tendon-derived stem cells (TDSCs) to indicate the tissue origin from which the stem cells were isolated in vitro. Based on the work of other sources of MSCs and specific work on TDSCs, some properties of TDSCs have been characterized / implicated in vitro. Despite these findings, tend...