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Journal of Cellular and Molecular Medicine

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  1. Different types of cultured human adult Cardiac Progenitor Cells have a high degree of transcriptome similarity.

    Journal of Cellular and Molecular Medicine 18(11):2147 (2014) PMID 25311343

  2. Cross-communication between histone H3 and H4 acetylation and Akt-mTOR signalling in prostate cancer cells.

    Journal of Cellular and Molecular Medicine 18(7):1460 (2014) PMID 24779401

    Molecular tumour targeting has significantly improved anti-cancer protocols. Still, the addition of molecular targeting to the treatment regime has not led to a curative breakthrough. Combined mammalian target of Rapamycin (mTOR) and histone deacetylase (HDAC) inhibition has been shown not only to e...
  3. Reprogramming to a pluripotent state modifies mesenchymal stem cell resistance to oxidative stress.

    Journal of Cellular and Molecular Medicine 18(5):824 (2014) PMID 24528612

    We analysed enzyme activities in these cell types. Catalase and superoxide dismutase activities were reduced in mb-iPSC and H9 when compared with mbMSC. Finally, cell adhesion under OS conditions was impaired in mb-iPSC when compared with mbMSC, albeit similar to H9. Thus, reprogramming leads to pro...
  4. Telocytes in liver: electron microscopic and immunofluorescent evidence.

    Journal of Cellular and Molecular Medicine 17(12):1537 (2013) PMID 24266938

    We used transmission electron microscopy and immunofluorescence (double labelling for CD34 and c-kit/CD117, or vimentin, or PDGF Receptor-α, or β) to provide evidence for the existence of TCs in mice liver. The distribution of TCs in liver was found to be of similar density in the four hepatic lobes...
  5. A new gamboge derivative compound 2 inhibits cancer stem-like cells via suppressing EGFR tyrosine phosphorylation in head and neck squamous ...

    Journal of Cellular and Molecular Medicine 17(11):1422 (2013) PMID 24112466

    We identified a new gamboge derivative, Compound 2 (C2), which presents eminent suppression effects on cancer cells. Interestingly, when compared with cisplatin (CDDP), C2 effectively suppresses the growth of both cancer stem-like cells and non-cancer stem-like cells derived from head and neck squam...
  6. Combination therapies in Myeloproliferative Neoplasms: why do we need them and how to identify potential winners?

    Journal of Cellular and Molecular Medicine 17(11):1410 (2013) PMID 24373502

  7. Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects.

    Journal of Cellular and Molecular Medicine 17(8):958 (2013) PMID 23802593 PMCID PMC3780531

    The direct targets of extremely low and microwave frequency range electromagnetic fields (EMFs) in producing non-thermal effects have not been clearly established. However, studies in the literature, reviewed here, provide substantial support for such direct targets. Twenty-three studies have shown...
  8. Myometrial immune cells contribute to term parturition, preterm labour and post-partum involution in mice.

    Journal of Cellular and Molecular Medicine 17(1):90 (2013) PMID 23205502

    We hypothesized that the peripheral leucocytes are recruited to uterine tissues by locally produced cytokines where they contribute to the initiation of parturition. Mouse uteri were collected (i) during gestation, TL and post-partum (PP), (ii) during PTL initiated by intrauterine infusion of LPS (1...
  9. Cardiac telocytes were decreased during myocardial infarction and their therapeutic effects for ischaemic heart in rat.

    Journal of Cellular and Molecular Medicine 17(1):123 (2013) PMID 23205601

    We also found that simultaneous transplantation of cardiac telocytes in the infarcted and border zones of the heart decreased the infarction size and improved myocardial function. These data indicate that cardiac telocytes, their secreted factors and microvesicles, and the microenvironment may be st...
  10. Perivascular cells for regenerative medicine.

    Journal of Cellular and Molecular Medicine 16(12):2851 (2012) PMID 22882758

    We and others recently described that MSC originate from two types of perivascular cells, namely pericytes and adventitial cells and contain the in situ counterpart of MSC in developing and adult human organs, which can be prospectively purified using well defined cell surface markers. Pericytes enc...