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Journal of Cellular and Molecular Medicine

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  1. Poly(ADP-ribose) polymerase inhibition with HYDAMTIQ reduces allergen-induced asthma-like reaction, bronchial hyper-reactivity and airway re...

    Journal of Cellular and Molecular Medicine 18(3):468 (2014) PMID 24444146

    Our findings support the proposal that PARP inhibitors could have a therapeutic potential to reduce chronic lung inflammation, airway damage and remodelling in severe unresponsive asthmatic patients. © 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd an...
  2. CD34+ VEGFR-3+ progenitor cells have a potential to differentiate towards lymphatic endothelial cells.

    Journal of Cellular and Molecular Medicine 18(3):422 (2014) PMID 24450475

    We assessed differentiation of a novel population of EPCs towards lymphatic endothelial cells and their lymphatic formation. CD34(+) VEGFR-3(+) EPCs were isolated from mononuclear cells of human cord blood by fluorescence-activated cell sorting. These cells expressed CD133 and displayed the phenotyp...
  3. Molecular, genetic and stem cell-mediated therapeutic strategies for spinal muscular atrophy (SMA).

    Journal of Cellular and Molecular Medicine 18(2):187 (2014) PMID 24400925

    We would like to outline the most interesting therapeutic strategies that are currently developing, which are represented by molecular, gene and stem cell-mediated approaches for the treatment of SMA. © 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd...
  4. Electrophysiology of human cardiac atrial and ventricular telocytes.

    Journal of Cellular and Molecular Medicine 18(2):355 (2014) PMID 24467431

    We examined myocardial chamber-specific TCs identified in atrial and ventricular fibroblast culture using immunocytochemistry and studied their electrophysiological property by whole-cell patch clamp. Atrial and ventricular TCs with extended telopodes and alternating podoms and podomers that express...
  5. Clinical applications of palifermin: amelioration of oral mucositis and other potential indications.

    Journal of Cellular and Molecular Medicine 17(11):1371 (2013) PMID 24251854

    Mucositis is one of the most significant toxicities in cancer patients undergoing cytotoxic treatment. It can have a negative impact on both quality of life and health economics. Severe oral mucositis can contribute to hospitalization, need for narcotic analgesics, total parentral nutrition, subopti...
  6. Methylation profiling of SOCS1, SOCS2, SOCS3, CISH and SHP1 in Philadelphia-negative myeloproliferative neoplasm.

    Journal of Cellular and Molecular Medicine 17(10):1282 (2013) PMID 24131863

    We studied the methylation status of SOCS1, SOCS2 and SOCS3, CISH and SHP1 by methylation-specific polymerase chain reaction (MSP) in cell lines and 45 diagnostic marrow samples of Ph-ve MPN. Moreover, we attempted to explain the discordance of methylation frequency by mapping the studied MSP primer...
  7. Cancer, stem cell misplacement and cancer stem cells.

    Journal of Cellular and Molecular Medicine 17(9):1194 (2013) PMID 23855541

    The cell of origin of cancer as well as cancer stem cells is still a mystery. In a recent issue of JCMM, Wang et al. challenged the conventional somatic genetic mutation model of multi-stage carcinogenesis of breast cancer and proposed that 'Invasive cancers are not necessary from preformed in situ...
  8. Non-apoptotic function of caspases in a cellular model of hydrogen peroxide-associated colitis.

    Journal of Cellular and Molecular Medicine 17(7):901 (2013) PMID 23742011

    We mimicked ROS exposure of the epithelium in IBD using non-tumour human colonic epithelial cells (HCEC) and hydrogen peroxide (H2 O2 ). A population of HCEC survived H2 O2 -induced oxidative stress via JNK-dependent cell cycle arrests. Caspases, p21(WAF1) and γ-H2AX were identified as JNK-regulated...
  9. Impaired surface expression and conductance of the KCNQ4 channel lead to sensorineural hearing loss.

    Journal of Cellular and Molecular Medicine 17(7):889 (2013) PMID 23750663 PMCID PMC3729637

    We report here that decreased cell surface expression and impaired conductance of the KCNQ4 channel are two mechanisms underlying hearing loss in DFNA2. In HEK293T cells, a dramatic decrease in cell surface expression was detected by immunofluorescent microscopy and confirmed by Western blot for the...
  10. Telocytes: new insight into the pathogenesis of gallstone disease.

    Journal of Cellular and Molecular Medicine 17(6):734 (2013) PMID 23551596

    The major mechanisms of gallstone formation include biliary cholesterol hypersecretion, supersaturation and crystallization, mucus hypersecretion, gel formation and bile stasis. Gallbladder hypomotility seems to be a key event that triggers the precipitation of cholesterol microcrystals from supersa...