Journal of Cellular and Molecular Medicine
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- Ingenta, Ovid, Proquest, Wiley from 2000, CSA, and Rcgp
Cancer, stem cell misplacement and cancer stem cells.
The cell of origin of cancer as well as cancer stem cells is still a mystery. In a recent issue of JCMM, Wang et al. challenged the conventional somatic genetic mutation model of multi-stage carcinogenesis of breast cancer and proposed that 'Invasive cancers are not necessary from preformed in situ...
Telocytes: new insight into the pathogenesis of gallstone disease.
The major mechanisms of gallstone formation include biliary cholesterol hypersecretion, supersaturation and crystallization, mucus hypersecretion, gel formation and bile stasis. Gallbladder hypomotility seems to be a key event that triggers the precipitation of cholesterol microcrystals from supersa...
Luteolin suppresses UVB-induced photoageing by targeting JNK1 and p90 RSK2.
We sought to investigate the effects of luteolin on UVB-induced photoageing and the molecular mechanisms involved, using HaCaT human keratinocytes and SKH-1 hairless mice. Luteolin was found to inhibit UVB-induced MMP-1 expression in HaCaT cells, as well as UVB-induced activation of AP-1, a well-kno...
MicroRNA-126 regulates the induction and function of CD4(+) Foxp3(+) regulatory T cells through PI3K/AKT pathway.
We reported that miR-126 was expressed in mouse and human Tregs. Further study showed that silencing of miR-126 using miR-126 antisense oligonucleotides (ASO) could significantly reduce the induction of Tregs in vitro. Furthermore, miR-126 silencing could obviously reduce the expression of Foxp3 on...
Neddylation dysfunction in Alzheimer's disease.
We review the functions of neddylation and summarize evidence suggesting that dysfunction of neddylation is involved in Alzheimer's disease. © 2012 The Authors Journal of Cellular and Molecular Medicine © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd....
A novel regulation of VEGF expression by HIF-1α and STAT3 in HDM2 transfected prostate cancer cells.
We speculated that HDM2 might play a major role in hypoxia-induced metastatic process. For verification of this hypothesis, wild-type LNCaP prostate cancer cells and HDM2 transfected LNCaP-MST (HDM2 stably transfected) cells were studied. The data obtained from our experiments revealed that the HDM2...
Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic dysfunction.
We argue for widespread use of Drosophila as a novel myocardial aging model by (1) describing diastolic dysfunction in flies, (2) discussing how critical pathways involved in dysfunction are conserved across species and (3) demonstrating the advantage of an atomic force microscopy-based analysis met...
Is PDGFR an important target for E-3810?
We have recently reported on the same compound  - that we named E-3810 - as correctly quoted by the authors. We were pleased to see that, in spite of the different experimental models used and of the different methodologies applied, Zhou et al. reported a consistent set of data confirming that E-...
Epigallocatechin-3-gallate induces mesothelioma cell death via H(2) O(2) -dependent T-type Ca(2+) channel opening.
We found that EGCG is selectively cytotoxic to MMe cells with respect to normal mesothelial cells. MMe cell viability was inhibited by predominant induction of apoptosis at lower doses and necrosis at higher doses. EGCG elicited H(2) O(2) release in cell cultures, and exogenous catalase (CAT) abroga...
Enhanced suicidal erythrocyte death in mice carrying a loss-of-function mutation of the adenomatous polyposis coli gene.
We estimated cell membrane scrambling from annexin V binding, cell size from forward scatter and cytosolic ATP utilizing luciferin-luciferase in isolated erythrocytes from apc(Min/+) mice and wild-type mice (apc(+/+) ). Clearance of circulating erythrocytes was estimated by carboxyfluorescein-diace...