Biomechanics and Modeling in Mechanobiology
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Three-dimensional surface geometries of the rabbit soleus muscle during contraction: input for biomechanical modelling and its validation.
We present in this study a comprehensive data set of the rabbit soleus muscle consisting of the muscles' characteristic force responses (active and passive), its three-dimensional shape during isometric, isotonic and isokinetic contraction experiments including the spatial arrangement of muscle tiss...
Stress and strain adaptation in load-dependent remodeling of the embryonic left ventricle.
These results emphasize the importance of appropriate metrics and the role of trabecular tissue in evaluating the evolution of stress and strain in relation to pressure-induced adaptation....
Atrial fibrillation pacing decreases intravascular shear stress in a New Zealand white rabbit model: implications in endothelial function.
We hypothesized that rapid and irregular pacing reduced intravascular shear stress (ISS) with implication to modulating endothelial responses. To simulate AF, we paced the left atrial appendage of New Zealand White rabbits (n = 4) at rapid and irregular intervals. Surface electrical cardiograms were...
On the paradoxical determinations of the lacuno-canalicular permeability of bone.
We propose therefore a Kozeny-like law obtained by a numerical method which relates the permeability to the textural parameters of cortical bone microstructure. Moreover, we suggest possible explanations for this paradox considering the empirical difficulties and possible multiphysical effects....
Biomechanics of meniscus cells: regional variation and comparison to articular chondrocytes and ligament cells.
These results show that cellular biomechanics vary regionally in the knee meniscus and that meniscus cells are biomechanically similar to ligament cells. The mechanical properties of musculoskeletal cells determined in this study may be useful for the development of mathematical models or the design...
Erratum to: Microstructural and biomechanical alterations of the human aorta as a function of age and location.
The fiber orientation in the coronary arterial wall at physiological loading evaluated with a two-fiber constitutive model.
We propose a new modeling constraint concerning the in-situ fiber orientation (β (phys)). β (phys), which is a major contributor to the arterial stress-strain behavior, was determined for porcine and human coronary arteries using a mixed numerical-ex...
Experimental measurement of dynamic fluid shear stress on the aortic surface of the aortic valve leaflet.
Aortic valve (AV) calcification is a highly prevalent disease with serious impact on mortality and morbidity. Although exact causes and mechanisms of AV calcification are unclear, previous studies suggest that mechanical forces play a role. Since calcium deposits occur almost exclusively on the aort...
Strain-based estimation of time-dependent transmural myocardial architecture in the ovine heart.
These results support a previously suggested accordion-like wall-thickening mechanism of the myocardial sheets....
A dynamical study of the mechanical stimuli and tissue differentiation within a CaP scaffold based on micro-CT finite element models.
The control of the mechanical stimuli transmitted to the cells is critical for the design of functional scaffolds for tissue engineering. The objective of this study was to investigate the dynamics of the mechanical stimuli transmitted to the cells during tissue differentiation in an irregular morph...