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Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours a...
This approach can potentially be applied to any kind of RNA sequencing data for analysing differential sequence representation between biological sample sets....
Host-symbiont co-speciation and reductive genome evolution in gut symbiotic bacteria of acanthosomatid stinkbugs.
Complex chloroplast RNA metabolism: just debugging the genetic programme?
Mitochondrial network morphology: building an integrative, geometrical view.
The morphology of mitochondrial networks is complex and highly varied, yet vital to cell function. The first step toward an integrative understanding of how mitochondrial morphology is generated and regulated is to define the interdependent geometrical features and their dynamics that together gener...
Plasmodium falciparum encodes a conserved active inhibitor-2 for Protein Phosphatase type 1: perspectives for novel anti-plasmodial therapy.
We present evidence that Plasmodium falciparum, the causative agent of the most deadly form of malaria, expresses a structural homolog of mammalian I2, named PfI2. Biochemical, in vitro and in vivo studies revealed that PfI2 binds PP1 and inhibits its activity. We further showed that the motifs 12KT...
Open questions: reflections on plant development and genetics.
Two structure papers, a call from Frankfurt airport, and how to escape from reviewer delays: An interview with Peter Walter.
Systematic curation of protein and genetic interaction data for computable biology.
Phylogenomics supports microsporidia as the earliest diverging clade of sequenced fungi.
We exploit the recent availability of six complete microsporidian genomes to re-assess the long-standing question of their phylogenetic position. We show that microsporidians have a similar low level of conservation of gene neighborhood with other groups of fungi when controlling for the confounding...
Screening for genes that wire the cerebral cortex.
Thalamocortical projections convey visual, somatosensory and auditory information to the cerebral cortex. A recent report in Neural Development shows how a forward genetic screen has enabled the identification of novel mutations affecting specific decision points of thalamocortical axon pathfinding....