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Therapeutic bioactive microcarriers: Co-delivery of growth factors and stem cells for bone tissue engineering.
Novel microcarriers made of sol-gel-derived bioactive glasses were developed for delivering therapeutic molecules effectively while cultivating stem cells for bone tissue engineering. Silica sols with varying concentration of Ca (0-30mol.%) were formulated into microspheres ranging from 200 to 300μm...
In vitro and in vivo studies on biodegradable CaMgZnSrYb high-entropy bulk metallic glass.
We fabricated the Ca20Mg20Zn20Sr20Yb20 high-entropy bulk metallic glass because of the unique properties of high-entropy alloys. Our results showed that the mechanical properties and corrosion behavior were enhanced. The in vitro tests showed that the Ca20Mg20Zn20Sr20Yb20 high-entropy bulk metallic...
Corrosion resistance of a composite polymeric coating applied on biodegradable AZ31 magnesium alloy.
The high corrosion rate of magnesium alloys is the main drawback to their widespread use, especially in biomedical applications. There is a need for developing new coatings that provide simultaneously corrosion resistance and enhanced biocompatibility. In this work, a composite coating containing po...
Biomimetic coating of magnesium alloy for enhanced corrosion resistance and calcium phosphate deposition.
Degradable metals have been suggested as biomaterials with revolutionary potential for bone-related therapies. Of these candidate metals, magnesium alloys appear to be particularly attractive candidates because of their non-toxicity and outstanding mechanical properties. Despite their having been wi...
Aptamers that bind to the hemagglutinin of the recent pandemic influenza virus H1N1 and efficiently inhibit agglutination.
We have selected RNA aptamers (D-12 and D-26) that specifically target the HA protein of the recent pandemic influenza virus pdmH1N1 (A/California/07/2009). Among the selected aptamers the D-26 aptamer showed higher affinity for the HA of pdmH1N1 and was able to distinguish HA derived from other sub...
Combining decellularized human adipose tissue extracellular matrix and adipose-derived stem cells for adipose tissue engineering.
Repair of soft tissue defects resulting from lumpectomy or mastectomy has become an important rehabilitation process for breast cancer patients. This study aimed to provide an adipose tissue engineering platform for soft tissue defect repair by combining decellularized human adipose tissue extracell...
The emergence of an unusual stiffness profile in hierarchical biological tissues.
We study the stiffness of non-overlapping staggered arrays, a case that has not previously been considered in the literature, and introduce closed-form analytical expressions for its Young's modulus. These expressions are then used to estimate the stiffness of natural staggered biocomposites such as...
Protein release from dihydroxyacetone-based poly(carbonate ester) matrices.
We report on the hydrolytic degradation of directly compressed discs comprised of statistically random polycarbonate esters based on lactic acid and dihydroxyacetone. The controlled release of two model proteins, bovine serum albumin and lysozyme, was explored using two percentage loadings (5 and 10...
A new metaphyseal bone defect model in osteoporotic rats to study biomaterials for the enhancement of bone healing in osteoporotic fractures...
The intention of this study was to establish a new critical size animal model that represents clinically relevant situations with osteoporotic bone status and internally fixated metaphyseal defect fractures in which biomaterials for the enhancement of fracture healing in osteoporotic fracture defect...
In vitro bone exposure to strontium improves bone material level properties.
In rats treated with strontium ranelate, the ultimate load of intact bone is increased and associated with changes in microstructure and material level properties. Evaluation by micro-computed-tomography-based finite element analysis has shown that these changes independently contribute to the impro...