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  1. DNA methylation controls unmethylated transcription start sites in the genome in trans.

    Epigenomics 9(5):611 (2017) PMID 28470094

    DNA methylation downregulates transcription. However, a large number of genes, which are unmethylated in the promoter region, are inactive. We tested the hypothesis that these genes are regulated by DNA methylation of upstream regulators.
  2. Crucial role of noncoding RNA in driving prostate cancer development and progression.

    Epigenomics 9(1):1 (2016) PMID 27885842

  3. Methods of epigenome editing for probing the function of genomic imprinting.

    Epigenomics 8(10):1389 (2016) PMID 27625199

    The curious patterns of imprinted gene expression draw interest from several scientific disciplines to the functional consequences of genomic imprinting. Methods of probing the function of imprinting itself have largely been indirect and correlational, relying heavily on conventional transgenics....
  4. Anti-fibrotic effects of valproic acid: role of HDAC inhibition and associated mechanisms.

    Epigenomics 8(8):1087 (2016) PMID 27411759

    Tissue injuries and pathological insults produce oxidative stress, genetic and epigenetic alterations, which lead to an imbalance between pro- and anti-fibrotic molecules, and subsequent accumulation of extracellular matrix, thereby fibrosis. Various molecular pathways play a critical role in fi...
  5. HDAC inhibitors with PD-1 blockade: a promising strategy for treatment of multiple cancer types?

    Epigenomics 8(8):1015 (2016) PMID 27410519

  6. Combinatorial epigenetic mechanisms and efficacy of early breast cancer inhibition by nutritive botanicals.

    Epigenomics 8(8):1019 (2016) PMID 27478970

    Aberrant epigenetic events are important contributors to the pathogenesis of different types of cancers and dietary botanicals with epigenetic properties can influence early cancer development leading to cancer prevention effects. We sought to investigate potential combinatorial effects of bioac...
  7. Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency.

    Epigenomics 8(8):1131 (2016) PMID 27419933

    Enforced ectopic expression of a cocktail of pluripotency-associated genes such as Oct4, Sox2, Klf4 and c-Myc can reprogram somatic cells into induced pluripotent stem cells (iPSCs). The remarkable proliferation ability of iPSCs and their aptitude to redifferentiate into any cell lineage makes t...
  8. How to make DNA methylome wide association studies more powerful.

    Epigenomics 8(8):1117 (2016) PMID 27052998

    Genome-wide association studies had a troublesome adolescence, while researchers increased statistical power, in part by increasing subject numbers. Interrogating the interaction of genetic and environmental influences raised new challenges of statistical power, which were not easily bested by t...
  9. Responses of bovine early embryos to S-adenosyl methionine supplementation in culture.

    Epigenomics 8(8):1039 (2016) PMID 27419740

    There is a growing concern about the potential adverse effects of high dose folic acid (FA) supplementation before and during pregnancy. FA metabolism generates S-adenosyl methionine (SAM) which is an important cofactor of epigenetic programming. We sought to assess the impact of a large dose of...
  10. Recent advances in epigenomics in NSCLC: real-time detection and therapeutic implications.

    Epigenomics 8(8):1151 (2016) PMID 27479016

    NSCLC is an aggressive disease with one of the poorer prognosis among cancers. The disappointing response to chemotherapy drives the search for genetic biomarkers aimed at both attaining an earlier diagnosis and choosing the most appropriate chemotherapy. In this scenario, epigenomic markers, su...
  11. Efficiency of methylated DNA immunoprecipitation bisulphite sequencing for whole-genome DNA methylation analysis.

    Epigenomics 8(8):1061 (2016) PMID 27266718

    We compared four common methods for measuring DNA methylation levels and recommended the most efficient method in terms of cost and coverage. The DNA methylation status of liver and stomach tissues was profiled using four different methods, whole-genome bisulphite sequencing (WG-BS), targeted bi...
  12. LSD1: biologic roles and therapeutic targeting.

    Epigenomics 8(8):1103 (2016) PMID 27479862

    LSD1 (KDM1A; BHC110; AOF2) was the first protein reported to exhibit histone demethylase activity and has since been shown to have multiple essential roles in mammalian biology. Given its enzymatic activity and its high-level expression in many human malignancies, a significant recent focus has ...
  13. Epigenetic epidemiology as a tool to understand the role of immunity in chronic disease.

    Epigenomics 8(8):1007 (2016) PMID 27411030

  14. A central role of H3K4me3 extended chromatin domains in gene regulation.

    Epigenomics 8(8):1011 (2016) PMID 27410771

  15. Clinical development of TargomiRs, a miRNA mimic-based treatment for patients with recurrent thoracic cancer.

    Epigenomics 8(8):1079 (2016) PMID 27185582

    miRNAs are responsible for post-transcriptional control of gene expression, and are frequently downregulated in cancer. It has become well established that restoring miRNA levels can inhibit tumor growth, and many studies have demonstrated this in preclinical models. This in turn has led to the ...
  16. Are the effects of IVF on DNA methylation driven by intracytoplasmic sperm injection and male infertility?

    Epigenomics 8(7):881 (2016) PMID 27366826

  17. Epigenetic quality check - how good are your mesenchymal stromal cells?

    Epigenomics 8(7):889 (2016) PMID 27366986

  18. Adverse maternal exposures, methylation of glucocorticoid-related genes and perinatal outcomes: a systematic review.

    Epigenomics 8(7):925 (2016) PMID 27381417

    Maternal environmental exposures affect perinatal outcomes through epigenetic placental changes. We examine the literature addressing associations between adverse maternal exposures, perinatal outcomes and methylation of key genes regulating placental cortisol metabolism. We searched three datab...
  19. Mutant IDH: a targetable driver of leukemic phenotypes linking metabolism, epigenetics and transcriptional regulation.

    Epigenomics 8(7):945 (2016) PMID 27431380

    Aberrant epigenomic programming is a hallmark of acute myeloid leukemia. This is partially due to somatic mutations that perturb cytosine methylation, histone post-translational modifications and transcription factors. Remarkably, mutations in the IDH1 and IDH2 genes perturb the epigenome throug...
  20. SLC6A4 promoter region methylation and socio-emotional stress response in very preterm and full-term infants.

    Epigenomics 8(7):895 (2016) PMID 27381173

    The present study is part of a prospective micro-longitudinal research project and reports on the association between SLC6A4 methylation and socio-emotional stress response in very preterm (VPT) and full-term (FT) infants. SLC6A4 methylation was assessed at birth and discharge in 32 VPT infants,...