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  1. Corrigendum.
    Author(s) unavailable

    Epigenomics 6(6):690 (2014) PMID 25531261

  2. The mitochondrial epigenome: a role in Alzheimer's disease?

    Epigenomics 6(6):665 (2014) PMID 25531259 PMCID PMC4329914

    Considerable evidence suggests that mitochondrial dysfunction occurs early in Alzheimer's disease, both in affected brain regions and in leukocytes, potentially precipitating neurodegeneration through increased oxidative stress. Epigenetic processes are emerging as a dynamic mechanism through wh...
  3. Epigenetic mechanisms of breast cancer: an update of the current knowledge.

    Epigenomics 6(6):651 (2014) PMID 25531258

    Epigenetic alterations are heritable changes in gene expression that occur without causing any change in DNA sequence. They are important key factors for cancer development and prognosis. Breast cancer is induced by the accumulation of altered gene regulation. Besides genetic mutations, epigenet...
  4. Environmental challenge, epigenetic plasticity and the induction of altered phenotypes in mammals.

    Epigenomics 6(6):623 (2014) PMID 25531256

    The level of transcriptional activity of a gene is regulated by epigenetic processes. There is compelling evidence that environmental challenges throughout the life course can induce phenotypic change. In this review, we summarize the current evidence, focusing specifically on the effects of nut...
  5. Examining peripheral DNA methylation in behavioral epigenetic and epigenetic psychiatry: opportunities and challenges.

    Epigenomics 6(6):581 (2014) PMID 25531252

  6. DNA cytosine methylation and hydroxymethylation at the borders.

    Epigenomics 6(6):563 (2014) PMID 25531248 PMCID PMC4321890

  7. Single nucleotide polymorphisms on DNA methylation microarrays: precautions against confounding.

    Epigenomics 6(6):577 (2014) PMID 25531251

  8. Strategies for validation and testing of DNA methylation biomarkers.

    Epigenomics 6(6):603 (2014) PMID 25531255

    DNA methylation is a stable covalent epigenetic modification of primarily CpG dinucleotides that has recently gained considerable attention for its use as a biomarker in different clinical settings, including disease diagnosis, prognosis and therapeutic response prediction. Although the advent o...
  9. Genetic variants of methionine metabolism and DNA methylation.

    Epigenomics 6(6):585 (2014) PMID 25531253

    Altered DNA methylation is associated with important and common pathologies such as cancer. The origin of altered DNA methylation is unknown. The methyl groups for DNA methylation are provided by methionine metabolism. This metabolism is characterized by a high interindividual variability, which...
  10. Epigenetic mechanisms regulating differentiation of neural stem/precursor cells.

    Epigenomics 6(6):637 (2014) PMID 25531257

    Differentiation of neural stem/precursor cells (NS/PCs) into neurons, astrocytes and oligodendrocytes during mammalian brain development is a carefully controlled and timed event. Increasing evidences suggest that epigenetic regulation is necessary to drive this. Here, we provide an overview of ...
  11. DNA methylation is a key factor in understanding differentiation phenotype in esophageal squamous cell carcinoma.

    Epigenomics 6(6):567 (2014) PMID 25531249

  12. Epigenomics and targeted therapy in cancer.

    Epigenomics 6(6):571 (2014) PMID 25531250

  13. From Prader-Willi syndrome to psychosis: translating parent-of-origin effects into schizophrenia research.

    Epigenomics 6(6):677 (2014) PMID 25531260

    Prader-Willi syndrome (PWS) is a relatively rare disorder that originates from paternally inherited deletions and maternal disomy (mUPD) within the 15q11-q13 region or alterations in the PWS imprinting center. Evidence is accumulating that mUPD underlies high prevalence of psychosis among PWS pa...
  14. Biological and biochemical modulation of DNA methylation.

    Epigenomics 6(6):593 (2014) PMID 25531254

    Epigenetic regulation is facilitated by a battery of proteins that act as 'writers' or 'erasers' to add or remove biochemical modifications to DNA and histone proteins. DNA modifications, histone modifications and long noncoding RNAs function interdependently through reciprocal crosstalk. This r...