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- Ovid from 2009, Rcgp, Ingenta, and Futurescience
Alternative sample diluents in bioanalytical LC-MS.
The problem of sample diluent in bioanalytical LC-MS is reviewed with a special focus on large-volume injections and non-miscible solvents with mobile phase components. These issues are related to the sample preparation approach, which in many instances provides the sample diluent before injecting t...
News & analysis.
Progress in the development of paper-based diagnostics for low-resource point-of-care settings.
We review key work in the areas of fluidic controls for automation in paper-based devices, readout methods that minimize dedicated equipment, and power and heating methods that are compatible with low-resource point-of-care settings. We also highlight a focused set of recent applications and discuss...
Universal immunogenicity validation and assessment during early biotherapeutic development to support a green laboratory.
We propose an efficient, fit-for-purpose, scientifically and statistically supported nonclinical immunogenicity assessment strategy. Utilization of a universal method and streamlined validation, while retaining comparability to conventional immunoassays and meeting the industry recommended standards...
Biomedical institutions join forces to fight cancer.
Acquisition of diagnostic tracers to enhance understanding of tau protein in Alzheimer's disease.
Software automation tools for increased throughput metabolic soft-spot identification in early drug discovery.
The ability to supplement high-throughput metabolic clearance data with structural information defining the site of metabolism should allow design teams to streamline their synthetic decisions. However, broad application of metabolite identification in early drug discovery has been limited, largely...
Characterization of the drug-to-antibody ratio distribution for antibody-drug conjugates in plasma/serum.
ADCs of three main drug conjugation platforms, linked via lysine, site-specific engineered cysteine or reduced interchain disulfide cysteine residues, were analyzed using affinity capture for sample enrichment coupled with LC-MS or hydrophobic interaction chromatography-UV for detection. These novel...
Quantitative imaging of a therapeutic peptide in biological tissue sections by MALDI MS.
Therapeutic peptides and proteins are being increasingly explored as potential therapeutic agents for molecular-targeted therapy, and the requirement for quantitative bioanalytical tools for such molecules has been discussed. The distribution of octreotide, a synthetic octapeptide analog of somatost...
Capillary microsampling in the regulatory environment: validation and use of bioanalytical capillary microsampling methods.
Capillary microsampling (CMS) has recently been introduced as a response to the demands for more ethical use of laboratory animals according to the 3R principles. In CMS, an exact volume of the blood, plasma or other biofluid is collected in a capillary from which it is washed out, resulting in a di...