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  1. Named entity recognition for bacterial Type IV secretion systems.

    PLoS ONE 6(3):e14780 (2011) PMID 21468321 PMCID PMC3066171

    Research on specialized biological systems is often hampered by a lack of consistent terminology, especially across species. In bacterial Type IV secretion systems genes within one set of orthologs may have over a dozen different names. Classifying research publications based on biological proce...
  2. Seasonality of MRSA infections.

    PLoS ONE 6(3):e17925 (2011) PMID 21468350 PMCID PMC3065770

    Using MRSA isolates submitted to our hospital microbiology laboratory January 2001-March 2010 and the number of our emergency department (ED) visits, quarterly community-associated (CA) and hospital-associated (HA) MRSA infections were modeled using Poisson regressions. For pediatric patients, a...
  3. Virulence characteristics and genetic affinities of multiple drug resistant uropathogenic Escherichia coli from a semi urban locality in India.

    PLoS ONE 6(3):e18063 (2011) PMID 21464963 PMCID PMC3064663

    Extraintestinal pathogenic Escherichia coli (ExPEC) are of significant health concern. The emergence of drug resistant E. coli with high virulence potential is alarming. Lack of sufficient data on transmission dynamics, virulence spectrum and antimicrobial resistance of certain pathogens such as...
  4. Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats.

    PLoS ONE 6(3):e17644 (2011) PMID 21464978 PMCID PMC3064568

    Bronchiolitis obliterans (BO) is a fibrotic lung disease that occurs in a variety of clinical settings, including toxin exposures, autoimmunity and lung or bone marrow transplant. Despite its increasing clinical importance, little is known regarding the underlying disease mechanisms due to a lac...
  5. An assessment of H1N1 influenza-associated acute respiratory distress syndrome severity after adjustment for treatment characteristics.

    PLoS ONE 6(3):e18166 (2011) PMID 21464952 PMCID PMC3064596

    Pandemic influenza caused significant increases in healthcare utilization across several continents including the use of high-intensity rescue therapies like extracorporeal membrane oxygenation (ECMO) or high-frequency oscillatory ventilation (HFOV). The severity of illness observed with pandemi...
  6. Bacillus anthracis interacts with plasmin(ogen) to evade C3b-dependent innate immunity.

    PLoS ONE 6(3):e18119 (2011) PMID 21464960 PMCID PMC3064659

    The causative agent of anthrax, Bacillus anthracis, is capable of circumventing the humoral and innate immune defense of the host and modulating the blood chemistry in circulation to initiate a productive infection. It has been shown that the pathogen employs a number of strategies against immun...
  7. MicroRNA expression signatures of bladder cancer revealed by deep sequencing.

    PLoS ONE 6(3):e18286 (2011) PMID 21464941 PMCID PMC3065473

    MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression. They are aberrantly expressed in many types of cancers. In this study, we determined the genome-wide miRNA profiles in bladder urothelial carcinoma by deep sequencing. We detected 656 differentially expressed k...
  8. Early divergent host responses in SHIVsf162P3 and SIVmac251 infected macaques correlate with control of viremia.

    PLoS ONE 6(3):e17965 (2011) PMID 21464951 PMCID PMC3064595

    We previously showed intravaginal inoculation with SHIVsf162p3 results in transient viremia followed by undetectable viremia in most macaques, and some displayed subsequent immunity to superinfection with pathogenic SIVmac251. Here we compare early T cell activation, proliferation, and plasma cy...
  9. Amyotrophic lateral sclerosis is associated with hypolipidemia at the presymptomatic stage in mice.

    PLoS ONE 6(3):e17985 (2011) PMID 21464953 PMCID PMC3064597

    To demonstrate that hypolipidemia is a typical feature of the mouse model of amyotrophic lateral sclerosis (ALS) and to assess the association between hypolipidemia and disease stage, dietary intake, and sex. We compared daily dietary intake, body weight, and serumlipid and glucose levels in ALS...
  10. XMeis3 is necessary for mesodermal Hox gene expression and function.

    PLoS ONE 6(3):e18010 (2011) PMID 21464931 PMCID PMC3065463

    Hox transcription factors provide positional information during patterning of the anteroposterior axis. Hox transcription factors can co-operatively bind with PBC-class co-factors, enhancing specificity and affinity for their appropriate binding sites. The nuclear localisation of these co-factor...
  11. Slaughterhouse pigs are a major reservoir of Streptococcus suis serotype 2 capable of causing human infection in southern Vietnam.

    PLoS ONE 6(3):e17943 (2011) PMID 21464930 PMCID PMC3065462

    Streptococcus suis is a pathogen of major economic significance to the swine industry and is increasingly recognized as an emerging zoonotic agent in Asia. In Vietnam, S. suis is the leading cause of bacterial meningitis in adult humans. Zoonotic transmission is most frequently associated with s...
  12. Dominant cone-rod dystrophy: a mouse model generated by gene targeting of the GCAP1/Guca1a gene.

    PLoS ONE 6(3):e18089 (2011) PMID 21464903 PMCID PMC3065489

    Cone dystrophy 3 (COD3) is a severe dominantly inherited retinal degeneration caused by missense mutations in GUCA1A, the gene encoding Guanylate Cyclase Activating Protein 1 (GCAP1). The role of GCAP1 in controlling cyclic nucleotide levels in photoreceptors has largely been elucidated using kn...
  13. Local cattle and badger populations affect the risk of confirmed tuberculosis in British cattle herds.

    PLoS ONE 6(3):e18058 (2011) PMID 21464920 PMCID PMC3065452

    The control of bovine tuberculosis (bTB) remains a priority on the public health agenda in Great Britain, after launching in 1998 the Randomised Badger Culling Trial (RBCT) to evaluate the effectiveness of badger (Meles meles) culling as a control strategy. Our study complements previous analyse...
  14. Similarity in recombination rate estimates highly correlates with genetic differentiation in humans.

    PLoS ONE 6(3):e17913 (2011) PMID 21464928 PMCID PMC3065460

    Recombination varies greatly among species, as illustrated by the poor conservation of the recombination landscape between humans and chimpanzees. Thus, shorter evolutionary time frames are needed to understand the evolution of recombination. Here, we analyze its recent evolution in humans. We c...
  15. Gecko CD59 is implicated in proximodistal identity during tail regeneration.

    PLoS ONE 6(3):e17878 (2011) PMID 21464923 PMCID PMC3065455

    Several adult reptiles, such as Gekko japonicus, have the ability to precisely re-create a missing tail after amputation. To ascertain the associated acquisition of positional information from blastemal cells and the underlying molecular mechanism of tail regeneration, a candidate molecule CD59 ...
  16. Nanogram-scale preparation and NMR analysis for mass-limited small volatile compounds.

    PLoS ONE 6(3):e18178 (2011) PMID 21464906 PMCID PMC3065492

    Semiochemicals are often produced in infinitesimally small quantities, so their isolation requires large amounts of starting material, not only requiring significant effort in sample preparation, but also resulting in a complex mixture of compounds from which the bioactive compound needs to be p...
  17. Enhanced transduction and replication of RGD-fiber modified adenovirus in primary T cells.

    PLoS ONE 6(3):e18091 (2011) PMID 21464908 PMCID PMC3065494

    Adenoviruses are often used as vehicles to mediate gene delivery for therapeutic purposes, but their research scope in hematological cells remains limited due to a narrow choice of host cells that express the adenoviral receptor (CAR). T cells, which are attractive targets for gene therapy of nu...
  18. Variations on fibrinogen-erythrocyte interactions during cell aging.

    PLoS ONE 6(3):e18167 (2011) PMID 21464904 PMCID PMC3065490

    Erythrocyte hyperaggregation, a cardiovascular risk factor, is considered to be caused by an increase in plasma adhesion proteins, particularly fibrinogen. We have recently reported a specific binding between fibrinogen and an erythrocyte integrin receptor with a β(3) or β(3)-like subunit. In th...
  19. Regulatory T cell induction during Plasmodium chabaudi infection modifies the clinical course of experimental autoimmune encephalomyelitis.

    PLoS ONE 6(3):e17849 (2011) PMID 21464982 PMCID PMC3064572

    Experimental autoimmune encephalomyelitis (EAE) is used as an animal model for human multiple sclerosis (MS), which is an inflammatory demyelinating autoimmune disease of the central nervous system characterized by activation of Th1 and/or Th17 cells. Human autoimmune diseases can be either exac...
  20. Altered gene expression in pulmonary tissue of tryptophan hydroxylase-1 knockout mice: implications for pulmonary arterial hypertension.

    PLoS ONE 6(3):e17735 (2011) PMID 21464983 PMCID PMC3064573

    The use of fenfluramines can increase the risk of developing pulmonary arterial hypertension (PAH) in humans, but the mechanisms responsible are unresolved. A recent study reported that female mice lacking the gene for tryptophan hydroxylase-1 (Tph1(-/-) mice) were protected from PAH caused by c...