Frontiers in bioscience (scholar edition)
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Psychological stressors as interventions: good out of the evil.
We have highlighted effects of PS on diseases while simultaneously building on the modes of operation of PS to alter physiology and its further implications in developing potential psychotherapeutic methods for disease treatment....
Operation 'p53 Hunt' to combat cancer: theaflavins in action.
With phytochemicals executing a plethora of anti-tumor mechanisms, targeting the 'guardian angel' p53 appears to be a critical strategy to energize the process of cancer therapeutics. Regulation of anti-tumor p53 functions by dietary plant polyphenols particularly black tea and its active component...
Prophylactic vaccines for prevention of prostate cancer.
Prostate cancer is the most prevalent cancer and the second leading cause of cancer death in men. There are various modalities for treatment of prostate cancer. Immunotherapy with several vaccines and antibodies has also been successfully used with positive clinical outcome in prostate cancer patien...
Therapeutic applications of NSAIDS in cancer: special emphasis on tolfenamic acid.
We provide a summary on the potential benefits of NSAIDs in a variety of human cancers with more emphasis on tolfenamic acid....
Thrombomodulin in the treatment of atherothrombotic diseases.
Thrombomodulin (TM) is a membrane-bound glycoprotein receptor r thrombin in the protein C activation pathway. Since its discovery in the 1980s as an anticoagulant protein, recent data suggest that TM plays an important role in modulating cellular proliferation, adhesion and inflammation. A soluble T...
Importance of TRP channels in pain: implications for stress .
Though stress is an integrated part of the modern life, defining stress in biological systems is difficult. Anxiety, medication, metabolic disorder, neuro-endocrinological abnormalities, immunological responses, neuro-immune interaction and several other internal and external factors are important w...
Causes and consequences of low grade endotoxemia and inflammatory diseases .
Increasing clinical observations reveal that persistent low-grade inflammation is associated with the pathogenesis of severe chronic diseases such as atherosclerosis, diabetes, and aging-related neurological diseases. Intriguingly, low levels of circulating Gram-negative bacterial endotoxin lipopoly...
Role of microRNAs in leukemia stem cells.
Leukemia cells can carry a small subset of poorly differentiated cells, which are considered to be precursors of lymphoblasts, myeloblasts, or monoblasts. Thus these cells are also called leukemia stem cells (LSCs) because they are capable of instigating, maintaining and serially propagating leukemi...
Small RNA in spermatogenesis and male infertility.
We explain how some cases of male infertility can be a product of complications in specific small RNA functions. The future direction section offers insight into how infertility treatment may be approached with a novel perspective....
The potential origin of glioblastoma initiating cells.
Despite intensive clinical and laboratory research and effort, Glioblastoma remains the most common and invariably lethal primary cancer of the central nervous system. The identification of stem cell and lineage-restricted progenitor cell populations within the adult human brain in conjunction with...