Oncotarget

Print ISSN
1949-2553
Electronic ISSN
1949-2553

  1. Mutation spectrum of TP53 gene predicts clinicopathological features and survival of gastric cancer.

    Oncotarget 7(27):42252 (2016) PMID 27323394

    TP53 gene is frequently mutated in gastric cancer (GC), but the relationship with clinicopathological features and prognosis is conflicting. Here, we screened TP53 mutation spectrum of 214 GC patients in relation to their clinicopathological features and prognosis. TP53 nonsilent mutations were ...
  2. CRISPR/Cas9 therapeutics: a cure for cancer and other genetic diseases.

    Oncotarget (2016) PMID 27250031

    Cancer is caused by a series of alterations in genome and epigenome mostly resulting in activation of oncogenes or inactivation of cancer suppressor genes. Genetic engineering has become pivotal in the treatment of cancer and other genetic diseases, especially the formerly-niche use of clustered ...
  3. Wnt/_-catenin pathway transactivates microRNA-150 that promotes EMT of colorectal cancer cells by suppressing CREB signaling.

    Oncotarget (2016) PMID 27285761

    A hallmark of aberrant activation of the Wnt/_-catenin signaling pathway has been observed in most colorectal cancers (CRC), but little is known about the role of non-coding RNAs regulated by this pathway. Here, we found that miR-150 was the most significantly upregulated microRNA responsive to e...
  4. CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter.

    Oncotarget (2016) PMID 27356740

    DNA hypermethylation at the promoter of tumour-suppressor genes is tightly correlated with their transcriptional repression and recognized as the hallmark of majority of cancers. Epigenetic silencing of tumour suppressor genes impairs their cellular functions and activates a cascade of events dri...
  5. Functional oncogene signatures guide rationally designed combination therapies to synergistically induce breast cancer cell death.

    Oncotarget (2016) PMID 27153554

    A critical first step in the personalized approach to cancer treatment is the identification of activated oncogenes that drive each tumor. The Identification of driver oncogenes on a patient-by-patient basis is complicated by the complexity of the cancer genome and the fact that a particular gene...
  6. Artificial small RNA for sequence specific cleavage of target RNA through RNase III endonuclease Dicer.

    Oncotarget (2016) PMID 27231846

    CRISPR-Cas9 system uses a guide RNA which functions in conjunction with Cas9 proteins to target a DNA and cleaves double-strand DNA. This phenomenon raises a question whether an artificial small RNA (asRNA), composed of a Dicer-binding RNA element and an antisense RNA, could also be used to induc...
  7. Androgen/androgen receptor axis maintains and promotes cancer cell stemness through direct activation of nanog transcription in hepatocellular carcinoma.

    Oncotarget (2016) PMID 27167111

    Hepatocellular carcinoma (HCC) is one of the most common and malignant cancers. The HCC incidence gets a strong sexual dimorphism as men are the major sufferers in this disaster. Although several studies have uncovered the presentative correlation between the axis of androgen/androgen receptor (A...
  8. Subanesthetic isoflurane relieves zymosan-induced neutrophil inflammatory response by targeting NMDA glutamate receptor and Toll-like receptor 2 signaling.

    Oncotarget 7(22):31772 (2016) PMID 27144523

    Neutrophil release of NO/ONOO- induces endothelial cell barrier dysfunction in inflammatory acute lung injury (ALI). Previous studies using zymosan-triggered inflammation and ALI model revealed that zymosan promotes inducible NO synthase (iNOS) expression in neutrophils, and that isoflurane inhi...
  9. A meta-analysis of MSI frequency and race in colorectal cancer.

    Oncotarget 7(23):34546 (2016) PMID 27120810

    African Americans (AA) are at a higher risk of colorectal cancer (CRC) and some studies report a higher frequency of microsatellite instability (MSI) in this population while others report lower frequency compared to Caucasians. To determine and evaluate the association of race and clinical fact...
  10. TGF-β1 and TGF-β2 abundance in liver diseases of mice and men.

    Oncotarget 7(15):19499 (2016) PMID 26799667

    TGF-β1 is a major player in chronic liver diseases promoting fibrogenesis and tumorigenesis through various mechanisms. The expression and function of TGF-β2 have not been investigated thoroughly in liver disease to date. In this paper, we provide evidence that TGF-β2 expression correlates with ...
  11. Synergistic antitumor activity of histone deacetylase inhibitors and anti-ErbB3 antibody in NSCLC primary cultures via modulation of ErbB receptors expression.

    Oncotarget 7(15):19559 (2016) PMID 26862736

    ErbB3, a member of the ErbB family receptors, has a key role in the development and progression of several cancers, including non-small cell lung cancer (NSCLC), and in the establishment of resistance to therapies, leading to the development of anti-ErbB3 therapies.In this study we demonstrated,...
  12. Molecular characterization of colorectal cancer patients and concomitant patient-derived tumor cell establishment.

    Oncotarget 7(15):19610 (2016) PMID 26909603

    We aimed to establish a prospectively enrolled colorectal cancer (CRC) cohort for targeted sequencing of primary tumors from CRC patients. In parallel, we established collateral PDC models from the matched primary tumor tissues, which may be later used as preclinical models for genome-directed t...
  13. Oncogenic epithelial cell-derived exosomes containing Rac1 and PAK2 induce angiogenesis in recipient endothelial cells.

    Oncotarget 7(15):19709 (2016) PMID 26919098

    The metastatic cascade describes the escape of primary tumour cells to distant secondary sites. Cells at the leading tumour edge are thought to undergo epithelial-mesenchymal transition (EMT), to enhance their motility and invasion for spreading. Whether EMT cells directly promote tumour angioge...
  14. PD-L1 expression as predictive biomarker in patients with NSCLC: a pooled analysis.

    Oncotarget 7(15):19738 (2016) PMID 26918451

    Clinical trials of immune checkpoints modulators, including both programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) inhibitors, have recently shown promising activity and tolerable toxicity in pre-treated NSCLC patients. However the predictive role of PD-L1 expression is s...
  15. Impact of age on efficacy of postoperative oxaliplatin-based chemotherapy in patients with rectal cancer after neoadjuvant chemoradiotherapy.

    Oncotarget 7(15):19643 (2016) PMID 26910371

    Clinical practice guidelines focusing on age-related adjuvant chemotherapy for rectal cancer are currently limited. The present study aimed to explore the impact of age on the efficacy of adjuvant oxaliplatin-based chemotherapy in patients with rectal cancer after neoadjuvant chemoradiotherapy. ...
  16. Knockdown of long non-coding RNA TP73-AS1 inhibits cell proliferation and induces apoptosis in esophageal squamous cell carcinoma.

    Oncotarget 7(15):19960 (2016) PMID 26799587

    Recent studies have shown that long non-coding RNAs (lncRNAs) are involved in a variety of biological processes and diseases in humans, including cancer. Our study serves as the first comprehensive analysis of lncRNA TP73-AS1 in esophageal cancer. We utilized a lncRNA microarray to analyze the e...
  17. Bile acid-FXRα pathways regulate male sexual maturation in mice.

    Oncotarget 7(15):19468 (2016) PMID 26848619

    The bile acid receptor Farnesol-X-Receptor alpha (FRXα) is a member of the nuclear receptor superfamily. FRXα is expressed in the interstitial compartment of the adult testes, which contain the Leydig cells. In adult, short term treatment (12 hours) with FRXα agonist inhibits the expression of s...
  18. Vascular patterns provide therapeutic targets in aggressive neuroblastic tumors.

    Oncotarget 7(15):19935 (2016) PMID 26918726

    Angiogenesis is essential for tumor growth and metastasis, nevertheless, in NB, results between different studies on angiogenesis have yielded contradictory results. An image analysis tool was developed to characterize the density, size and shape of total blood vessels and vascular segments in 4...
  19. Interplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion.

    Oncotarget 7(15):19483 (2016) PMID 26761212

    RNA-RNA and protein-RNA interactions are essential for post-transcriptional regulation in normal development and may be deregulated in cancer initiation and progression. The RNA-binding protein PCBP2, an oncogenic protein in human malignant gliomas, is an essential regulator of mRNA and miRNA bi...
  20. Development of a new outcome prediction model for Chinese patients with penile squamous cell carcinoma based on preoperative serum C-reactive protein, body mass index, and standard pathological risk factors: the TNCB score group system.

    Oncotarget 7(15):21023 (2016) PMID 26980738

    To determine the predictive value and feasibility of the new outcome prediction model for Chinese patients with penile squamous cell carcinoma. The 3-year disease-specific survival (DSS) survival (DSS) was 92.3% in patients with < 8.70 mg/L CRP and 54.9% in those with elevated CRP (P < 0.001). Th...