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Oncotarget

Electronic ISSN
1949-2553

  1. Mitophagy promotes replication of oncolytic Newcastle disease virus by blocking intrinsic apoptosis in lung cancer cells.

    Oncotarget 5(15):6365 (2014) PMID 25051374

    We found that NDV La Sota strain induced autophagy and preserved autophagic flux in non-small cell lung cancer cells. NDV-induced autophagy promoted viral replication by blocking cancer cells from caspase-dependent apoptosis. Moreover, we found that NDV recruited SQSTM1-mediated mitophagy to control...
  2. Eradication of metastatic melanoma through cooperative expression of RNA-based HDAC1 inhibitor and p73 by oncolytic adenovirus.

    Oncotarget 5(15):5893 (2014) PMID 25071017

    We constructed oncolytic viruses armed with an inhibitor of deacetylation and/or p73 to specifically target metastatic cancer. Arming of the viruses is aimed at lifting epigenetic blockage and re-opening apoptotic programs in a staggered manner enabling both, efficient virus replication and balanced...
  3. T cell-recruiting triplebody 19-3-19 mediates serial lysis of malignant B-lymphoid cells by a single T cell.

    Oncotarget 5(15):6466 (2014) PMID 25115385

    These results highlight that central domains capable of engaging different immune effectors can be incorporated into the triplebody format to provide more individualized therapy tailored to a patient's specific immune status....
  4. Urokinase receptor promotes ovarian cancer cell dissemination through its 84-95 sequence.

    Oncotarget 5(12):4154 (2014) PMID 24980826

    We had shown that the uPAR sequence corresponding to 84-95 residues, linking D1 and D2 domains (uPAR84-95), drives cell migration and angiogenesis in a protease-independent manner. This study was aimed at defining the contribution of uPAR84-95 sequence to invasion of ovarian cancer cells. Now, we pr...
  5. Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer.

    Oncotarget 5(12):4269 (2014) PMID 24962213

    We report that a protein-complex activated by the Ras effector p38γ MAPK is a novel therapeutic target for K-Ras-dependent colon cancer. Unbiased proteomic screening and immune-precipitation analyses identified p38γ interaction with heat shock protein 90 (Hsp90) and K-Ras in K-Ras MT, but not wild-t...
  6. The localization of HER4 intracellular domain and expression of its alternately-spliced isoforms have prognostic significance in ER+ HER2- b...

    Oncotarget 5(11):3919 (2014) PMID 25003574 PMCID PMC4116531

    We analyzed the expression levels of HER4 extracellular (JM-a and JM-b) and intracellular (CYT-1 and CYT-2) domains as well as 4ICD localization, and tested the relationship with clinicopathological characteristics and prognosis. The predominantly-expressed extracellular domain was JM-a, and lower C...
  7. Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personaliz...

    Oncotarget 5(10):3273 (2014) PMID 24830350 PMCID PMC4102809

    We have developed small molecule inhibitors against APE1 repair nuclease activity. In the current study we explored a synthetic lethal relationship between PTEN and APE1 in melanoma. Clinicopathological significance of PTEN mRNA and APE1 mRNA expression was investigated in 191 human melanomas. Precl...
  8. Up-regulation of neogenin-1 increases cell proliferation and motility in gastric cancer.

    Oncotarget 5(10):3386 (2014) PMID 24930499 PMCID PMC4102817

    We demonstrated here the function and regulatory mechanism of neogenin-1 in gastric cancer. Neogenin-1 ablation decreased proliferation and migration of gastric cancer cells, whereas its over-expression reversed these effects. Xenografted analyses using gastric cancer cells displayed statistically s...
  9. STAT3 down regulates LC3 to inhibit autophagy and pancreatic cancer cell growth.

    Oncotarget 5(9):2529 (2014) PMID 24796733 PMCID PMC4058024

    We investigated the potential of Nx to modulate autophagy, reactive oxygen species (ROS), and their crosstalk. Our results show that Nx inhibits autophagy and decreases ROS generation. Pharmacological inhibition of autophagy led to decreased ROS generation and proliferation with no significant effec...
  10. Minoxidil may suppress androgen receptor-related functions.

    Oncotarget 5(8):2187 (2014) PMID 24742982 PMCID PMC4039155

    We hypothesized that minoxidil may influence the AR or its downstream signaling. These tests revealed that minoxidil suppressed AR-related functions, decreasing AR transcriptional activity in reporter assays, reducing expression of AR targets at the protein level, and suppressing AR-positive LNCaP c...