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BioMed Research International

Print ISSN
2314-6133
Electronic ISSN
2314-6141
Publisher
Hindawi Publishing Corporation

  1. N-(1-pyrenyl) maleimide induces bak oligomerization and mitochondrial dysfunction in jurkat cells.

    BioMed Research International 2015:798489 (2015) PMID 25632401 PMCID PMC4302375

    We show that treatment of Jurkat cells with NPM leads to Bak oligomerization, loss of mitochondrial membrane potential (Δψm), and release of cytochrome C from mitochondria to cytosol. Induction of Bak oligomerization appears to play a critical role in NPM-induced apoptosis, as downregulation of Bak...
  2. Biofunctionalized nanofibers using arthrospira (spirulina) biomass and biopolymer.

    BioMed Research International 2015:967814 (2015) PMID 25667931 PMCID PMC4312563

    We used a highly integrated method, by adjusting the properties of the spinning solutions, where the cyanophyte Arthrospira (formally Spirulina) was the single source for nanofiber biofunctionalization. We investigated nanofibers using PHB extracted from Spirulina and the bacteria Cupriavidus necato...
  3. Aortic arch calcification predicts the renal function progression in patients with stage 3 to 5 chronic kidney disease.

    BioMed Research International 2015:131263 (2015) PMID 25695046 PMCID PMC4324897

    We retrospectively determined AoAC and cardiomegaly by chest X-ray in 237 patients, followed up for at least three years without entering dialysis and classified into 4 groups according to the presence or absence of AoAC and cardiomegaly. The change in renal function was measured by the slope of est...
  4. Proposal for a new noncontact method for measuring tongue moisture to assist in tongue diagnosis and development of the tongue image analyzi...

    BioMed Research International 2015:249609 (2015) PMID 25699260 PMCID PMC4324740

    We hypothesized that moisture appears as a gloss in captured images and measured the amount of water on the tongue surface in 13 subjects. The results showed a high correlation between the degree of gloss and the amount of water on the tongue surface and suggested that the moisture on the tongue can...
  5. The Involvement of Microtubules and Actin during the Infection of Japanese Encephalitis Virus in Neuroblastoma Cell Line, IMR32.

    BioMed Research International 2015:695283 (2015) PMID 25705678 PMCID PMC4331156

    The role of the cytoskeleton, actin, and microtubules were examined during the process of Japanese encephalitis (JEV) infection in a human neuroblastoma cell line, IMR32. Cytochalasin D and nocodazole were used to depolymerise the cellular actin and microtubules, respectively, in order to study the...
  6. Identification of susceptibility genes for peritoneal, ovarian, and deep infiltrating endometriosis using a pooled sample-based genome-wide ...

    BioMed Research International 2015:461024 (2015) PMID 25722978 PMCID PMC4334615

    We therefore conducted a pooled sample-based GWAS and distinguished histologically confirmed endometriosis subtypes. We performed an initial discovery step on 10-individual pools (two pools per condition). After quality control filtering, a Monte-Carlo simulation was used to rank the significant SNP...
  7. Preoperative RAS mutational analysis is of great value in predicting follicular variant of papillary thyroid carcinoma.

    BioMed Research International 2015:697068 (2015) PMID 25648502 PMCID PMC4306358

    We reconfirmed the molecular profiles in a large number of FVPTCs and investigated the efficacy of the preoperative mutational analysis in indeterminate thyroid nodules. BRAF V600E/K601E and RAS mutational analysis was performed on 187 FVPTCs. Of these, 132 (70.6%) had a point mutation in one of the...
  8. Analysis of single nucleotide polymorphisms within ADAM12 and risk of knee osteoarthritis in a Chinese Han population.

    BioMed Research International 2015:518643 (2015) PMID 25667922 PMCID PMC4312576

    We have identified that the rs1871054 variant within the ADAM12 gene is a risk factor for increased osteoarthritis susceptibility and severity....
  9. The correlation between miRNA and lymph node metastasis in gastric cancer.

    BioMed Research International 2015:543163 (2015) PMID 25688358 PMCID PMC4320935

    Lymph node metastasis (LNM) in gastric cancer is associated with higher rate of cancer recurrence and poor prognosis. As a result, a reliable biomarker for the prediction of LNM is important and would be valuable in the clinical practice. MiRNA microarray revealed that ten miRNAs were expressed sign...
  10. Identification of potential transcriptomic markers in developing ankylosing spondylitis: a meta-analysis of gene expression profiles.

    BioMed Research International 2015:826316 (2015) PMID 25688367 PMCID PMC4320922

    We performed the meta-analysis to identify consistently differentially expressed (DE) genes in ankylosing spondylitis and further performed functional interpretation (gene ontology analysis and pathway analysis) of the DE genes identified in the meta-analysis. Three microarray datasets (26 cases and...