BioMed Research International
- Print ISSN
- Hindawi Publishing Corporation
Defining Loci in restriction-based reduced representation genomic data from nonmodel species: sources of bias and diagnostics for optimal cl...
We use published genomes from a tunicate, stickleback, and soybean to illustrate the potential for bioinformatic artifacts and introduce a protocol to minimize two sources of error expected from similarity-based de-novo clustering of stacked reads: the splitting of alleles into different clusters, w...
Genetics of Alzheimer's disease.
We review the known genetics of early- and late-onset Alzheimer's disease....
Aorta structural alterations in term neonates: the role of birth and maternal characteristics.
To evaluate the influence of selected maternal and neonatal characteristics on aorta walls in term, appropriately grown-for-gestational age newborns. Age, parity, previous abortions, weight, height, body mass index before and after delivery, smoking, and history of hypertension, of diabetes, of card...
Development of bioadhesive chitosan superporous hydrogel composite particles based intestinal drug delivery system.
Bioadhesive superporous hydrogel composite (SPHC) particles were developed for an intestinal delivery of metoprolol succinate and characterized for density, porosity, swelling, morphology, and bioadhesion studies. Chitosan and HPMC were used as bioadhesive and release retardant polymers, respectivel...
Antibodies against food antigens in patients with autistic spectrum disorders.
Immune system of some autistic patients could be abnormally triggered by gluten/casein assumption. The prevalence of antibodies to gliadin and milk proteins in autistic children with paired/impaired intestinal permeability and under dietary regimen either regular or restricted is reported. 162 ASDs...
High intensity physical exercise and pain in the neck and upper limb among slaughterhouse workers: cross-sectional study.
We investigated the association between high intensity physical exercise and pain among 595 slaughterhouse workers in Denmark, Europe. Using logistic regression analyses, odds ratios for pain and work disability as a function of physical exercise, gender, age, BMI, smoking, and job position were est...
Network analysis of neurodegenerative disease highlights a role of Toll-like receptor signaling.
We present an efficient computational method based on protein-protein interaction network (PPI) to model the functional network of NDs. The aim of this work is fourfold: (i) reconstruction of a PPI network relating to the NDs, (ii) construction of an association network between diseases based on pro...
Mesenchymal stem cells for regenerative therapy: optimization of cell preparation protocols.
Administration of bone marrow-derived mesenchymal stem cells (MSCs) is an innovative approach for the treatment of a range of diseases that are not curable by current therapies including heart failure. A number of clinical trials have been completed and many others are ongoing; more than 2,000 patie...
The evidence for nerve repair in obstetric brachial plexus palsy revisited.
Strong scientific validation for nerve reconstructive surgery in infants with Obstetric Brachial Plexus Palsy is lacking, as no randomized trial comparing surgical reconstruction versus conservative treatment has been performed. A systematic review of the literature was performed to identify studies...
DNA methylation pattern in overweight women under an energy-restricted diet supplemented with fish oil.
These results suggest that the n-3 PUFA-induced changes in the expression of these genes in PBMC are not mediated by DNA methylation, although other epigenetic mechanisms cannot be discarded....