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  • In This Issue
    Our Eukaryotic Past miRNA Decoy in Tumor Suppression Histone Chaperones as Regional Managers Gentleman in Waiting Escorts Argonaute...
    Cell 140: (2010)
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  • Genetics Select
    Faster, smaller, easier, and better—DNA sequencing technologies have improved by quantum leaps in the past decade. This Genetics Se...
    Cell 140: (2010)
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  • Membrane Curvature in Synaptic Vesicle Fusion and Beyond.
    We discuss how local curvature generated by these and other proteins may stimulate membrane fusion and discuss the potential implica...
    Cell 140:601 (2010)
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  • The Incredible Expanding Ancestor of Eukaryotes.
    Comparing the genome sequences of free-living organisms in the five eukaryotic supergroups enables predictions to be...
    Cell 140:606 (2010)
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  • Angelman Syndrome: Finding the Lost Arc.
    Angelman syndrome is a neurodevelopmental disorder caused by mutations in the maternally inherited UBE3A gene, which...
    Cell 140:608 (2010)
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  • A Penetrating Look at Stochasticity in Development.
    In recent work published in Nature, Raj et al. (2010) use single mRNA molecule quantification to show that variation...
    Cell 140:610 (2010)
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  • MicroRNAs: From Decay to Decoy.
    MicroRNAs interact with Argonaute proteins to guide posttranscriptional gene silencing. Eiring et al. (2010) now sho...
    Cell 140:612 (2010)
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  • TB: Screening for Responses to a Vile Visitor.
    Mycobacteria, the pathogens that cause tuberculosis and leprosy, establish long-term infections in host macrophages....
    Cell 140:615 (2010)
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  • Autoimmunity and the Clearance of Dead Cells.
    We discuss how the endogenous components of dead cells activate the immune system through both extracellular and intracellular pathw...
    Cell 140:619 (2010)
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  • The Genome of Naegleria gruberi Illuminates Early Eukaryotic Versatility.
    We construct a comprehensive catalog of amoeboid-motility genes. The Naegleria genome, analyzed in the context of other protists, re...
    Cell 140:631 (2010)
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  • Protein Dynamics in Drug Combinations: a Linear Superposition of Individual-Drug Responses.
    We use a dynamic proteomics approach to accurately follow 15 protein levels in human cells in response to 13 different drugs. We fin...
    Cell 140:643 (2010)
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  • miR-328 Functions as an RNA Decoy to Modulate hnRNP E2 Regulation of mRNA Translation in Leukemic Blasts.
    We report that loss of miR-328 occurs in blast crisis chronic myelogenous leukemia (CML-BC) in a BCR/ABL dose- and kinase-dependent...
    Cell 140:652 (2010)
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  • Stc1: A Critical Link between RNAi and Chromatin Modification Required for Heterochromatin Integrity.
    We have identified a LIM domain protein, Stc1, that is required for centromeric heterochromatin integrity. Our analyses show that St...
    Cell 140:666 (2010)
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  • Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions.
    We report genome-wide profiles of H3 variants in mammalian embryonic stem cells and neuronal precursor cells. Genome-wide patterns o...
    Cell 140:678 (2010)
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  • The Tetrahymena Argonaute-Binding Protein Giw1p Directs a Mature Argonaute-siRNA Complex to the Nucleus.
    We identify Giw1p, which binds to Twi1p and is required for its nuclear localization. Furthermore, the endoribonuclease (Slicer) act...
    Cell 140:692 (2010)
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  • The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc.
    We report here that experience-driven neuronal activity induces Ube3A transcription and that Ube3A then regulates excitatory synapse...
    Cell 140:704 (2010)
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  • The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans.
    We report results from a forward genetic screen in zebrafish larvae that identify multiple mutant classes with distinct patterns of...
    Cell 140:717 (2010)
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  • Genome-wide Analysis of the Host Intracellular Network that Regulates Survival of Mycobacterium tuberculosis.
    We performed a genome-wide siRNA screen to identify host factors that regulated pathogen load in human macrophages infected with a v...
    Cell 140:731 (2010)
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  • An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man.
    We have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The comple...
    Cell 140:744 (2010)
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  • Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice
    No abstract is available for this article.
    Cell 140: (2010)
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  • SnapShot: Nucleotide Excision Repair.
    Cell 140:754 (2010)
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