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  • Double bromodomain protein BET-1 and MYST HATs establish and maintain stable cell fates in C. elegans.
    We show that the C. elegans acetylated-histone-binding protein BET-1 is required for the establishment and maintenance of stable fat...
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  • Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts.
    We found that myocyte enhancer factor 2C (MEF2C) and histone deacetylase 5 (HDAC5), two key regulators of cardiac hypertrophy, are t...
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  • A role for juvenile hormone in the prepupal development of Drosophila melanogaster.
    To elucidate the role of juvenile hormone (JH) in metamorphosis of Drosophila melanogaster, the corpora allata cells, which produce...
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  • {beta}-catenin deficiency causes DiGeorge syndrome-like phenotypes through regulation of Tbx1.
    We show that canonical Wnt-beta-catenin signaling negatively regulates Tbx1 expression and that mesenchymal inactivation of beta-cat...
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  • Activation of the skeletogenic gene regulatory network in the early sea urchin embryo.
    We show that the activation of the skeletogenic network occurs by a mechanism that is distinct from the transcriptional repression o...
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  • Runx1 and Runx2 cooperate during sternal morphogenesis.
    We generated mesenchymal-cell-specific and chondrocyte-specific Runx1-deficient mice [Prx1 Runx1(f/f) mice and alpha1(II) Runx1(f/f)...
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