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  • Touch Neurons Have a Good Sense of Direction
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  • BIN1: A Protein with Great Heart
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  • Current Affairs: A Mutation's-Eye View of Voltage Gating
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  • Paleovirology—Modern Consequences of Ancient Viruses
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  • Why We Conform
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  • Genomic Responses to Abnormal Gene Dosage: The X Chromosome Improved on a Common Strategy
    This new primer, which discusses a study by Zhang et al., provides an overview of the process by which chromosomes a...
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  • Living the Sweet Life: How Does a Plant Pathogenic Fungus Acquire Sugar from Plants?
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  • VertNet: A New Model for Biodiversity Data Sharing
    Responding to the urgent need to make biodiversity records broadly accessible, the natural history community turned...
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  • Absolute Humidity and the Seasonal Onset of Influenza in the Continental United States
    We extend these findings to the human population level, showing that the onset of increased wintertime influenza-related mortality i...
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  • Regulatory T Cells and Human Myeloid Dendritic Cells Promote Tolerance via Programmed Death Ligand-1
    We demonstrate that human Tregs promote the generation of myeloid dendritic cells (DC) with reduced capacity to stimulate effector T...
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  • Shape Invariant Coding of Motion Direction in Somatosensory Cortex
    We assess the invariance of neural representations of tactile motion direction with respect to other stimulus properties. To this en...
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  • Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth
    We determined that A20 (TNFAIP3), a regulator of cell survival and the NF-κB pathway, is overexpressed in GSCs relative to non-stem...
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  • Genome Sequence of the Pea Aphid Acyrthosiphon pisum
    We present the 464 Mb draft genome assembly of the pea aphid Acyrthosiphon pisum. This first published whole genome sequence of a ba...
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  • Expression in Aneuploid Drosophila S2 Cells
    We know very little about the relationship between gene copy number and expression in aneuploid cells. We determined copy number and...
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  • The Wnt Pathway Controls Cell Death Engulfment, Spindle Orientation, and Migration through CED-10/Rac
    We show, by an in depth 4-D microscopy analysis, that the Caenorhabditis elegans Wnt pathway signals to CED-10/Rac via two separate...
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  • Ciprofloxacin Causes Persister Formation by Inducing the TisB toxin in Escherichia coli
    We have found previously that one or more components of the SOS response induce persister formation after exposure to a DNA-damaging...
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  • A Novel High-Affinity Sucrose Transporter Is Required for Virulence of the Plant Pathogen Ustilago maydis
    We present a novel, plasma membrane-localized sucrose transporter (Srt1) from the corn smut fungus Ustilago maydis and its character...
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  • BIN1 Localizes the L-Type Calcium Channel to Cardiac T-Tubules
    We hypothesized that BIN1 not only exists at cardiac T-tubules, but it also localizes Cav1.2 to these membrane structures. We report...
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  • Voltage-Dependent Gating in a "Voltage Sensor-Less" Ion Channel.
    We have identified a remarkable point mutation that confers significant voltage dependence to Kir6.2, a ligand-gated channel that la...
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  • Using Structural Information to Change the Phosphotransfer Specificity of a Two-Component Chemotaxis Signalling Complex
    We present the 1.40 Å crystal structure of the histidine-containing phosphotransfer domain of the chemotaxis HPK, CheA3, in complex...
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  • mRNA Secondary Structures Fold Sequentially But Exchange Rapidly In Vivo
    We developed a system to probe mechanisms of secondary structure folding and exchange directly in vivo using self-cleavage to monito...
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