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  • Release of the mitochondrial endosymbiont helps explain sterile inflammation.
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  • Nanowire platform for mapping neural circuits.
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  • Inaugural Article: Some features of the spread of epidemics and information on a random graph.
    We focus on processes taking place on the network. In particular we are interested in how their behavior on networks differs from th...
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  • Rontgen's electrode-free elastomer actuators without electromechanical pull-in instability.
    Electrical actuators made from films of dielectric elastomers coated on both sides with stretchable electrodes may p...
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  • Solving the apparent diversity-accuracy dilemma of recommender systems.
    We introduce a new algorithm specifically to address the challenge of diversity and show how it can be used to resolve this apparent...
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  • Fermentable sugars by chemical hydrolysis of biomass.
    We report a high-yielding chemical process for the hydrolysis of biomass into monosaccharides. Adding water gradually to a chloride...
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  • Bioorganometallic mechanism of action, and inhibition, of IspH.
    We have investigated the mechanism of action of Aquifex aeolicus IspH [E-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) reductase...
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  • Fluctuation enhanced electrochemical reaction rates at the nanoscale.
    We show that at the nanoscale, the discreteness and stochasticity of an electron transfer event causes fluctuations of the electrode...
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  • Dual role of lignin in plant litter decomposition in terrestrial ecosystems.
    We evaluated the importance of litter chemistry on photodegradation of grass litter and cellulose substrates with varying levels of...
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  • Climatic context and ecological implications of summer fog decline in the coast redwood region.
    We present a novel record of summer fog frequency in the coast redwood region upon the basis of direct hourly measurements of cloud...
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  • Lattice thermal conductivity of MgO at conditions of Earth's interior.
    We predict the lattice thermal conductivity of MgO, previously used to estimate the thermal conductivity in the Earth, at conditions...
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  • Vitrification and levitation of a liquid droplet on liquid nitrogen.
    We observed that such vitrification events are accompanied by a Leidenfrost phenomenon, which impedes the heat transfer to cool the...
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  • Distributed neural system for general intelligence revealed by lesion mapping.
    We investigated the neural substrates of g in 241 patients with focal brain damage using voxel-based lesion-symptom mapping. A hiera...
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  • Specificity landscapes of DNA binding molecules elucidate biological function.
    We compare the DNA sequence specificities for different classes of proteins and engineered DNA binding molecules across the entire s...
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  • Female-specific flightless phenotype for mosquito control.
    Dengue and dengue hemorrhagic fever are increasing public health problems with an estimated 50-100 million new infec...
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  • Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by rather than by phosphoranes.
    Prior evidence supporting the direct observation of phosphorane intermediates in enzymatic phosphoryl transfer react...
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  • Sampling the N-terminal proteome of human blood.
    We present a method to label and isolate N-terminal peptides from human plasma and serum. This process dramatically reduces the comp...
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  • Appropriate maturation and folding of 16S rRNA during 30S subunit biogenesis are critical for translational fidelity.
    We identified a point mutation in S5, (G28D) that alters both SSU formation and translational fidelity in vivo, which is unprecedent...
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  • Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents.
    We uncovered that mPTPB subverts the innate immune responses by blocking the ERK1/2 and p38 mediated IL-6 production and promoting h...
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  • RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage.
    We report that p53 stabilization in the late phase after ionizing radiation correlates with active ubiquitination. We found that an...
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  • Multiple translational products from a five-nucleotide ribozyme.
    We show that a similar activity exists in a tiny, 5-nt-long RNA enzyme with a 3-nt active center. The small ribozyme initially trans...
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  • ParA2, a Vibrio cholerae chromosome partitioning protein, forms left-handed helical filaments on DNA.
    We found that purified ParA2 had ATPase activities comparable to other ParA homologs, but, unlike many other ParA homologs, did not...
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  • Follistatin-like-1, a diffusible mesenchymal factor determines the fate of epithelium.
    We have demonstrated that, in mouse oviductal development, the mesenchyme determines the fate of undetermined epithelial cells to be...
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  • Amoeboid organism solves complex nutritional challenges.
    We address this question in the acellular slime mold Physarum polycephalum and show that this extraordinary organism can make comple...
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  • Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis).
    The herbicide atrazine is one of the most commonly applied pesticides in the world. As a result, atrazine is the mos...
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  • Phylogenetic analysis of 83 plastid genes further resolves the early diversification of eudicots.
    Although Pentapetalae (comprising all core eudicots except Gunnerales) include approximately 70% of all angiosperms,...
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  • Mutation-selection models of coding sequence evolution with site-heterogeneous amino acid fitness profiles.
    We integrate recent developments in nonparametric statistical approaches to propose a probabilistic model that accounts for the hete...
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  • Arboreality has allowed for the evolution of increased longevity in mammals.
    We analyze a large dataset of mammalian longevity records to test whether arboreal mammals are characterized by greater longevities...
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  • Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans.
    We find that genetic defects in a peroxisomal beta-oxidation pathway cause size expansion in lipid droplets that are distinct from t...
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  • Rotational dynamics of DNA on the nucleosome surface markedly impact accessibility to a DNA repair enzyme.
    We find substantial differences in UDG-directed cleavage at uracils rotationally positioned toward (U-In) or away from (U-Out) the h...
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  • Peptide vaccines prevent tumor growth by activating T cells that respond to native tumor antigens.
    We have assembled a set of peptide variants for a mouse-colon tumor model to determine how to improve T-cell responses. These peptid...
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  • Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis.
    We have studied the action of this drug in the K/BxN mouse model of inflammatory arthritis after first crossing in a human CD20 tran...
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  • Critical role of IRF-5 in regulation of B-cell differentiation.
    We demonstrate that IRF-5 is involved in B-cell maturation and the stimulation of Blimp-1 expression. The Irf5(-/-) mice develop an...
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  • Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling.
    We implanted an immunodeficient mouse recipient with human BMC (hBMC)-seeded scaffolds. As in humans, TEVGs implanted in a mouse hos...
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  • Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis.
    We demonstrate a negative feedback loop for regulation of HIF-1 by REDD1, which plays a key role in tumor suppression. Genetic loss...
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  • High-throughput identification of protein localization dependency networks.
    We used a fluorescence microscopy screen optimized for high-throughput to find strains with anomalous temporal or spatial protein lo...
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  • Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence.
    We generated all the 254 combinations of reassortant viruses between A/chicken/South Kalimantan/UT6028/06 (SK06, H5N1) and A/Tokyo/U...
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  • Interactome analysis of longitudinal pharyngeal infection of cynomolgus macaques by group A Streptococcus.
    We performed genome-wide transcriptome analysis using a nonhuman primate model of experimental pharyngitis. We also identified host...
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  • Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA.
    We determined the crystal structures of SidM alone (residues 317-647) and SidM (residues 193-550) in complex with nucleotide-free WT...
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  • The Lucretian swerve: The biological basis of human behavior and the criminal justice system.
    It is widely believed, at least in scientific circles, that living systems, including mankind, obey the natural phys...
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  • Input-specific synaptic plasticity in the amygdala is regulated by neuroligin-1 via postsynaptic NMDA receptors.
    We have found that neuroligin-1 stabilizes the NMDA receptors residing in the postsynaptic membrane of amygdala principal neurons, w...
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  • Kupfer-type immunological synapse characteristics do not predict anti-brain tumor cytolytic T-cell function in vivo.
    We established brain tumors expressing the surrogate tumor antigen ovalbumin and labeled antigen-specific anti-glioma T cells using...
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  • Perceptron learning rule derived from spike-frequency adaptation and spike-time-dependent plasticity.
    We show that synaptic spike-time-dependent plasticity (STDP) combined with spike-frequency adaptation (SFA) in a single neuron toget...
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  • Topographic organization of macaque area LIP.
    We recorded blood oxygenation level-dependent signals with functional MRI from two macaques performing a difficult visual search tas...
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  • Toward discovery science of human brain function.
    We initiate this endeavor by gathering R-fMRI data from 1,414 volunteers collected independently at 35 international centers. We dem...
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  • Light-induced translocation of Drosophila visual Arrestin2 depends on Rac2.
    We show that light-dependent shuttling of the major arrestin in Drosophila photoreceptor cells, Arrestin2 (Arr2), occurs independent...
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  • Positive allosteric modulators of the human sweet taste receptor enhance sweet taste.
    We undertook the screening of a compound library using a cell-based assay for the human sweet taste receptor and a panel of selected...
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  • Molecular mechanism of the sweet taste enhancers.
    We reveal how these sweet enhancers work at the molecular level. Our data argue that the sweet enhancers follow a similar mechanism...
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  • Functional specializations for music processing in the human newborn brain.
    We used functional MRI to measure brain activity in 1- to 3-day-old newborns while they heard excerpts of Western tonal music and al...
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  • Cholesterol trafficking is required for mTOR activation in endothelial cells.
    We report that blockade of cholesterol trafficking through lysosome by a newly identified inhibitor of angiogenesis, itraconazole, l...
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  • Insulin enhances glucose-stimulated insulin secretion in healthy humans.
    We evaluated whether insulin regulates beta-cell function in healthy humans in vivo. Glucose-induced insulin secretion was assessed...
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  • Arabidopsis thaliana life without phytochromes.
    We were able to obtain it in the flowering locus T (ft) mutant background. The quintuple phytochrome mutant does not germinate in th...
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  • The PPH1 phosphatase is specifically involved in LHCII dephosphorylation and state transitions in Arabidopsis.
    We identify a phosphatase of Arabidopsis thaliana, called PPH1, which is specifically required for the dephosphorylation of light-ha...
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  • Correction for Jordan et al., Peptide vaccines prevent tumor growth by activating T cells that respond to native tumor antigens
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