Cytokines 27,460 articles
- Autocrine Motility Factor
- Growth Differentiation Factor 15
- Hematopoietic Cell Growth Factors
- Hepatocyte Growth Factor
- Interleukin 1 Receptor Antagonist Protein
Angiogenic cytokines and growth factors in systemic sclerosis
Systemic sclerosis is an autoimmune connective tissue disorder characterized by a widespread microangiopathy, autoimmunity and fibrosis of the skin and of various internal organs. Microangiopathy is characterized by a reduced capillary density and an irregular chaotic architecture th...
High-level soluble expression, purification, and functional characterization of the recombinant human leukemia inhibitory factor: a potentia...
These results present a sound strategy for the soluble production of rhLIF and other homologous tertiary structure cytokines consisting of four α-helices in a bundle for basic research, as well as clinical applications....
Multiple facets of NF-κB in the heart: to be or not to NF-κB.
We posit a novel paradigm in which the timing, duration of activation, and cellular context may explain mechanistically the differential outcomes of NF-κB signaling in the heart that may be essential for future development of novel therapeutic interventions designed to target NF-κB responses and hea...
Immunoglobulin isotypes and functional anti-FVIII antibodies in response to FVIII treatment in Balb/c and C57BL/6 haemophilia A mice.
We were interested in characterizing the spectrum of FVIII antibody formation and the primary and secondary immune responses after FVIII administration in two different exon 16-disrupted haemophilia A mouse strains, Balb/c and C57BL/6. Balb/c and C57BL/6 E16 haemophilia A mice were used in all exper...
Iron and the immune system.
Iron and immunity are closely linked: firstly by the fact that many of the genes/proteins involved in iron homoeostasis play a vital role in controlling iron fluxes such that bacteria are prevented from utilising iron for growth; secondly, cells of the innate immune system, monocytes...
Adipokine actions on cartilage homeostasis.
We review the present knowledge about the role of these adipokines in cartilage function as well as in inflammatory and degenerative joint diseases. Moreover, we describe some methodological approaches which can be utilized in the measurement of these adipokines in different biological matrices, lik...
Human knee synovial fluid cytokines correlated with grade of knee osteoarthritis--a pilot study.
These results add pilot data that can assist investigators in conducting a comparative observational study of the levels of inflammatory cytokines with radiologic and arthroscopic assessments of osteoarthritis....
The anti-inflammatory effects of ketamine: state of the art.
Inflammation is a major component in keeping the body in homeostasis. However, an overwhelmed inflammatory response may be associated to a loss of this homeostatic status, which may lead to tissue injury or organ dysfunction. A huge number of drugs interacts with the inflammatory response in a positi...
Chronic mucocutaneous candidiasis and congenital susceptibility to Candida.
To give an overview on the clinical spectrum and the molecular background of host defence against Candida. For many decades the molecular causes and the pathogenesis for an increased susceptibility to Candida - and fungal infections in general - have been elusive. In...
Prevention of colitis-associated carcinogenesis with infliximab.