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All Organic Chemicals Amidines Benzamidines Diminazene

Diminazene 45 articles


  1. Attempts to protect goats against challenge with Trypanosoma vivax by initiation of primary infections with large numbers of metacyclic tryp...

    Parasitology 97 ( Pt 3):383 (1988) PMID 3217138

    Attempts were made to immunize goats by infection with large numbers of metacyclic trypanosomes of a clone of Trypanosoma vivax, followed by chemotherapy. Five groups of 6 goats each were infected intradermally with 5 different doses of cultured metacyclics of T. vivax, ranging from 10(2) to 10(6) t...
  2. Characterization of Trypanosoma brucei brucei S-adenosyl-L-methionine decarboxylase and its inhibition by Berenil, pentamidine and methylgly...

    Biochemical Journal 237(3):685 (1986) PMID 3800910 PMCID 1147045

    Trypanosoma brucei brucei S-adenosyl-L-methionine (AdoMet) decarboxylase was found to be relatively insensitive to activation by putrescine as compared with the mammalian enzyme, being stimulated by only 50% over a 10,000-fold range of putrescine concentrations. The enzyme was not stimulated by up t...
  3. Studies on the comprehensive control of babesiasis in cattle and buffaloes.

    Tropical Animal Health and Production 29(4 Suppl):66S (1997) PMID 9512748

    These results indicated that this technique of controlling babesiosis is highly effective....
  4. A drug incubation Glossina infectivity test (DIGIT) to assess the susceptibility of Trypanosoma congolense bloodstream forms to trypanocidal...

    Acta Tropica 72(1):111 (1999) PMID 9924966

    Blood was collected from two Sahelian goats, experimentally infected with either a drug-sensitive cloned population of Trypanosoma congolense (IL 1180) or a multiple drug-resistant T. congolense stock (Samorogouan/89/CRTA/267) and incubated at 37 degrees C for 30 min and 12 h, respectively, in the p...
  5. The influence of the exocyclic amino group characteristic of GC base pairs on molecular recognition of specific nucleotide sequences in DNA ...

    Journal of Molecular Recognition 10(3):121 (1997) PMID 9408827

    These results establish that the location of the purine 2-amino group represents a critical determinant for recognition of DNA nucleotide sequences by the two drugs....
  6. The influence of supplementation with cotton seed cake on the resistance of Ugandan goats to primary and secondary challenges with Trypanoso...

    Veterinary Parasitology 70(1-3):67 (1997) PMID 9195711

    The present study investigated the influence of supplementation with cotton seed cake on the resistance of the Small East African breed of goats to primary and secondary challenges with Trypanosoma congolense and on their response to chemotherapy with diminazene aceturate. The supplemented group rec...
  7. Response of diminazene-resistant and diminazene-susceptible Trypanosoma congolense to treatment with diminazene when occurring as a mixed in...

    Annals of Tropical Medicine and Parasitology 88(6):595 (1994) PMID 7893173

    A study was carried out to determine whether a drug-resistant trypanosome population could influence the survival of a drug-sensitive population in mixed infections in goats. To identify both populations during the course of a mixed infection, a system for distinguishing them was developed; using a...
  8. Hematology of natural bovine trypanosomosis in the Brazilian Pantanal and Bolivian wetlands.

    Veterinary Parasitology 85(1):87 (1999) PMID 10447196

    We report hematological changes observed in natural cases of bovine trypanosomosis due to Trypanosoma vivax in beef and dairy cattle from Bolivian wetlands and Pantanal, Brazil. The main hematologic changes produced by T. vivax infections were anemia and severe leucopenia. The cattle presented macro...
  9. Changes in haematocrit after treatment of uncomplicated canine babesiosis: a comparison between diminazene and trypan blue, and an evaluatio...

    Journal of the South African Veterinary Associa... 67(2):77 (1996) PMID 8765067

    It has been suggested that the antibabesial drug diminazene causes a rapid decline in haematocrit after treatment of dogs with high Babesia canis parasitaemias, compared with trypan blue. To test this, 19 dogs with clinically mild to moderate, uncomplicated babesiosis were placed in low, moderate or...
  10. A simple epidemiological method for animal trypanosomiasis to provide relevant data for effective financial decision-making.

    Veterinary Parasitology 20(4):261 (1986) PMID 3087050

    The epidemiology of bovine trypanosomiasis on Galana Ranch, Kenya was studied for one year (July 1980--June 1981), using measurements from an experimental population of 3 types of Boran cattle. The results were applied to the estimated ranch population at risk, and an attempt was made to measure the...