Fibroblast Growth Factors 866 articles
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Giant cell tumor of bone. The role of fibroblast growth factor 3 positive mesenchymal stem cells in its pathogenesis.
The neoplastic stromal spindle-shaped subpopulation of cells in giant cell tumors are mesenchymal stem cells capable of inducing histiocyte proliferation. Retinoid acid is capable of inducing differentiation of the cells into mature osteoblasts. This should be further investigated in an in vivo mode...
Regulation of adrenocortical cell proliferation in culture.
The regulation of the proliferation of adrenocortical cells in culture is reviewed. The hormones and growth factors affecting adrenocortical proliferation in culture and their physiological relevance are discussed. The following general conclusions are made: (i) ACTH is growth-stimulatory in vivo, b...
The discovery of alpha-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis.
1The traditional view of calcium homeostasis is that it is maintained by two essential reactions. First, changes in extracellular Ca2+ are sensed in several distinct cell types, stimulating the secretion of parathyroid hormone (PTH), 1,25(OH)(2) D and calcitonin in response to the body's requirement...
Effect of serum amyloid A, HDL-apolipoprotein, on endothelial cell proliferation. Implication of an enigmatic protein to atherosclerosis.
Our results suggest that human SAA, both purified and recombinant, in concentrations relevant to mild acute phase events, significantly inhibit endothelial cell proliferation in a dose-dependent manner (e.g., 50 micrograms/ml causes approximately 88% inhibition; p < 0.001). This inhibition was atten...
Peptide growth factors and prostate cancer: new models, new opportunities.
We have developed and characterized the Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) animal model that expresses the oncogene SV40 T antigen specifically in the epithelium of the prostate. TRAMP develops spontaneous autochthonous prostate cancer compelte with distant site metastasis and can p...
Ontogenetic limb bone scaling in basic fibroblast growth factor (FGF-2) transgenic mice.
We collected radiographic and weight data longitudinally and obtained the length, proximal, distal, and minimum diaphyseal widths of the humerus, femur, and tibia. Because growth is nonlinear with respect to time, we used the Gompertz mathematical model to obtain parameters describing rate and timin...