Fibroblast Growth Factors 872 articles
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Changes in retinoic acid signaling alter otic patterning.
We elucidate the mechanisms that underlie these changes and show that they have origins in different tissues. Excess RA leads to ectopic foxi1 expression throughout the entire preplacodal domain. Foxi1 provides competence to adopt an otic fate. Subsequently, pax8, the expression of which depends upo...
Basic fibroblast growth factor promotes melanocyte migration via increased expression of p125(FAK) on melanocytes.
We have demonstrated that narrow-band ultraviolet B (UVB) irradiation stimulated cultured keratinocytes to release a significant amount of basic fibroblast growth factor (bFGF). Furthermore, narrow-band UVB enhanced migration of melanocytes via increased expression of phosphorylated focal adhesion k...
Activation of epiblast gene expression by the hypoblast layer in the prestreak chick embryo.
Which factors stimulate lens fiber cell differentiation in vivo?
Expression of Fgf4 during early development of the chick embryo.
We have therefore examined expression of endogenous Fgf4 mRNA in the developing chick embryo at stages when these processes are occurring. Expression was detected in the primitive streak from the onset of gastrulation. Notably, transient expression of transcripts was found in head process cells at t...
Effects of activated macrophages and fibroblast growth factor on random skin flap survival in swine.
The cellular and biochemical events following creation of a surgical wound are complex and incompletely understood. Our attempt to augment the natural role of the macrophage in wound healing by employing cytokines to activate these cells and to accelerate their arrival by implanting them into the wo...
Initiation of mammalian liver development from endoderm by fibroblast growth factors.
Autocrine and paracrine actions of intestinal fibroblast-derived insulin-like growth factors.
We conclude that IGF-II is a potent autocrine mitogen for intestinal fibroblasts. IGF-II interacts with other fibroblast-derived growth factors and ECM to stimulate proliferation of intestinal epithelial cells in a paracrine manner....
Comparative analysis of Otx2, Gbx2, Pax2, Fgf8 and Wnt1 gene expressions during the formation of the chick midbrain/hindbrain domain.
We propose a new nomenclature to differentiate the vesicles and constrictions observed in the avian MH domain at stage HH10 and HH20, based on the localization of the Gbx2/Otx2 common boundary....
Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development.
We show that in common with both these Lim genes, Clim-2 expression is regulated by signals from overlying epithelium. In both the developing face and the limb buds we identify Fgf-8 as the likely candidate signalling molecule that regulates Clim-2 expression. We show that in the mandibular arch, as...