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All Heterocyclic Compounds Alkaloids Harringtonines

Harringtonines 51 articles

  1. Asymmetric Total Synthesis and Revised Structure of Cephalezomine H

    Journal of Organic Chemistry 74(19):7592 (2009) PMID 19731926

    A revised structure of cephalezomine H, Cephalotaxus alkaloids, is presented. The originally assigned and revised structures of cephalezomine H were synthesized from the key intermediate for the synthesis of (-)-cephalotaxine.
  2. [The inducing effect of retinoic acid and harringtonine on differentiation of human leukemic cells in primary culture].

    Zhonghua Yixue Zazhi 68(9):509 (1988) PMID 3228752

  3. [Synthesis and antiulcer activity of 3,4-dihydro-hainanensine analogs].

    Yao xue xue bao = Acta pharmaceutica Sinica 33(9):682 (1998) PMID 12016872

    In order to search for new compounds with new mode of action, high antiulcer activity and lower toxicity, 26(13 pairs of diastereoisomer A and B) 3,4-dihydro-hananensine analogs were synthesized. All compounds were tested in M1 receptor combined assay and gastric ulcer induced by cold-immersion stre...
  4. [The crystal structures of harringtonine and homoharringtonine].

    Zhongguo yi xue ke xue yuan xue bao. Acta Acade... 10(4):283 (1988) PMID 2976317

  5. [Role of vascular endothelial growth factor (VEGF) in development and progress of refractory acute myeloid leukemia].

    Ai zheng = Aizheng = Chinese journal of cancer 22(8):844 (2003) PMID 12917032

    The mean VEGF concentration in the cell cultural supernatant of HL-60/VEGF(165) cells (399.07+/-12.45 ng/L) was 2-folds higher than that in HL-60/neo cells (184.45+/-10.53 ng/L)(P< 0.01). The VEGF(165)cDNA sense vector transfected HL-60 exhibited a 2-fold increase in VEGF secretion. The growth rate...
  6. [Isoharringtonine induces apoptosis in human leukemia HL-60 cell].

    Yao xue xue bao = Acta pharmaceutica Sinica 33(6):407 (1998) PMID 12016908

    These results are important impetus for further research and development of IHT as an anticancer agent....
  7. [Growth inhibition of human myeloid leukemia cells in vitro by harringtonine].

    Gan to kagaku ryoho. Cancer & chemotherapy 17(2):281 (1990) PMID 2301953

    We have demonstrated that harringtonine inhibited the growth of human myeloid leukemia cells in vitro at low concentrations. Together with the clinical data in which 28% of the patients could be induced into complete remission only by harringtonine, this agent may be used as a first choice of antile...
  8. The comprehensive evaluation on four indices of drug resistance in acute myeloid leukemia.

    Journal of Tongji Medical University 19(3):194 (1999) PMID 12840892

    To study sensitivity of drug resistance indexes and resistance manner in acute myeloid leukemia (AML), MTT drug sensitivity, growth types of CFU-L in vitro, Bcl-2 antigen and Bcl-2/Bax ratio and intracellular fluorescence intensity of daunorubicin (DNR) were determined. In 62 cases of AML, the posit...
  9. Resistance to apoptosis of harringtonine-resistant HL60 cells induced by tetrandrine.

    Zhongguo yao li xue bao = Acta pharmacologica S... 17(6):545 (1996) PMID 9863153

    The resistant cells had no cross resistance to Tet. Tet induced the sensitive but not the Har-resistant HL60 cells to apoptosis. The high phosphorylation of protein < 30 kDa occurred when the resistant cells were treated with Tet. Tet and Har increased the expression of c-myc mRNA in the sensitive H...
  10. [The PCNA immunohistochemical study of pterygium].

    [Zhonghua yan ke za zhi] Chinese journal of oph... 35(5):380 (1999) PMID 11835845

    There are cell proliferation and PCNA expression in pterygium. The homoharringtonine and dexamethasone local injection before the excision of pterygium can effectively decrease the PCNA expression and recurrence rate of pterygium. Local injection of dexamethasone before surgical excision has no infl...