Hepatic Stellate Cells 147 articles
[Stimulation of human hepatic stellate cells by cytochrome P4502E1-mediated oxidative stress].
I synthesis by hepatic stellate cells. Hydroxyproline excreted by LX2 was increased by CYP2E1. COL-1mRNA had no difference among the groups (F=0.73, P>0.05)....
Inflammation and hepatic fibrosis.
[Browicz's phagocytic cells and Kupffer's 'so-called stellate cells'].
Kupffer (1876) attempted to demonstrate nerve fibers in the liver, using the gold chloride method and found the star-shaped perisinusoidal cells by chance. He named these cells 'Sternzellen' (stellate cells). The stellate cells have been studied enthusiastically within the past thirty years. It has...
[Effect of beta-elemene on the proliferation, migration and RhoA expression of hepatic stellate cells induced by angiotensin II]
Different concentrations (from 1 to 10 micromol/L) of ANG II markedly promoted the growth of the HSC in a concentration dependent way (0 micromol/L ANG II, F = 112.640, P less than 0.01). 10, 8, 4 micromol/L ANGII significantly induced HSC migration, F = 117.496, P less than 0.01. Compared with the...
Antifibrotic activity of triterpenoids from the aerial parts of
In the course of screening antifibrotic activity of natural products employing HSC-T6, a rat hepatic stellate cell line, as an in vitro assay system, the methanolic extract of aerial parts of Euscaphis japonica (Tunb.) Kantiz (Staphyleaceae) showed significant inhibitory activity on HSC proliferatio...
Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development.
We have identified three distinct populations of fetal liver mesenchymal cells expressing both desmin and p75 neurotrophin receptor (p75NTR): HSCs in the liver parenchyma; perivascular mesenchymal cells expressing alpha-smooth muscle actin (alpha-SMA); and submesothelial cells associated with the ba...
Inhibitory effects of armepavine against hepatic fibrosis in rats.
Our study results showed that Arm exerted both in vitro and in vivo antifibrotic effects in rats, possibly through anti-NF-kappaB activation pathways....
Withagulatin A inhibits hepatic stellate cell viability and procollagen I production through Akt and Smad signaling pathways.
[Molecular study of the hepatic inflammation to fibrosis to cancer axis].
Role of p38 and JNK in liver ischemia and reperfusion.
We analyzed the participation of p38 and JNK in liver ischemia and reperfusion, as two individual members of the MAPK family of proteins. All papers referred to in PubMed for the past 15 years were analyzed to determine how and when these MAPKs were considered to be an intricate part...