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Metabolic Clearance Rate 2,055 articles


  1. Intake of 13C-4 creatine enables simultaneous assessment of creatine and phosphocreatine pools in human skeletal muscle by 13C MR spectrosco...

    Magnetic Resonance in Medicine 56(5):953 (2006) PMID 17036281

    The feasibility of a novel method for the noninvasive and local assessment of creatine (Cr) and phosphocreatine (PCr) dynamics in human skeletal muscle based on (13)C magnetic resonance (MR) spectroscopy is presented. A high dose of Cr, labeled at the guanidino C-4 position with (13)...
  2. The connecting tubule is the main site of the furosemide-induced urinary acidification by the vacuolar H+-ATPase.

    Kidney International 70(10):1706 (2006) PMID 16985514

    We used several mouse models performing renal clearance experiments and assessed the furosemide-induced urinary acidification. Increasing Na(+) delivery to the CNT and CCD by blocking Na(+) reabsorption in the thick ascending limb with furosemide enhanced urinary acidification and net acid excretion...
  3. Effect of congestive heart failure on mexiletine pharmacokinetics in a Japanese population.

    Biological & Pharmaceutical Bulletin 29(11):2267 (2006) PMID 17077526

    Mexiletine clearance was significantly lower in the CHF group when compared with the Non-CHF group (0.264+/-0.093 vs. 0.393+/-0.082 l/h/kg, mean+/-S.D., p<0.05). Further, the CL/F ratio was 50% lower in group NYHA III-IV when compared with the Non-CHF group, and the CL/F ratio tended to change in in...
  4. Pharmacokinetics of methadone.

    Journal of Pain & Palliative Care Pharmacotherapy 19(4):13 (2005) PMID 16431829

  5. Pharmacokinetics and intramuscular bioavailability of cefuroxime sodium in goats

    Research in Veterinary Science 69(3):6 (2000) PMID 11124092

    The pharmacokinetics of cefuroxime sodium, 20 and 40 mg kg(-1), were studied after i.v. and intramuscular injections in goats. Following single i.v. injections the serum concentration time curves of cefuroxime sodium were best fitted to a two-compartment open model. The drug was rapidly distributed...
  6. The role of endogenous interleukin-12 in resistance to murine cytomegalovirus (MCMV) infection and a novel action for endogenous IL-12 p40.

    Journal of Interferon & Cytokine Research 19(10):1145 (1999) PMID 10547154

    We demonstrate that mice deficient in either IL-12 p40 (p40-/-) or IL-12 p35 (p35-/-) are susceptible to murine cytomegalovirus (MCMV) infection in terms of survival (Balb/c p35-/-) and viral clearance (Balb/c p35-/- and Balb/c p40-/-), and this susceptibility may be correlated to a deficiency in se...
  7. [Distribution of 5-fluorouracil in plasma and pancreatic tissue of rats during the regional arterial infusion chemotherapy].

    Zhongguo yi xue ke xue yuan xue bao. Acta Acade... 21(5):390 (1999) PMID 12567439

    The regional arterial infusion chemotherapy is a better way for treating pancreatic carcinoma than the intravenous chemotherapy....
  8. Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery.

    Gene Therapy 6(4):643 (1999) PMID 10476224

    We have examined factors contributing to rapid elimination of poly(L-lysine) (pLL)/DNA complexes from the bloodstream, and implicate the binding of proteins to the polyelectrolyte complexes as a likely cause for their blood clearance. pLL/DNA complexes reisolated from serum associate with several pr...
  9. Excretion of progastrin products in human urine.

    American Journal of Physiology -- Legacy Content 276(4):G985 (1999) PMID 10198343

    We conclude that renal excretion of progastrin products is negligible compared with renal metabolism and that renal handling of the peptides depends on their molecular structure. Hence, the kidneys exhibited a higher excretion of NH2-terminal progastrin fragments than of carboxyamidated and especial...
  10. Menstrual cycle variability in midazolam pharmacokinetics.

    Journal of Clinical Pharmacology 39(3):275 (1999) PMID 10073327

    These results suggest no difference in hepatic CYP3A4 activity on menstrual cycle days 2, 13, and 21. Consideration of menstrual cycle variability in the metabolism of CYP3A4 substrates does not appear indicated in the dosing or design of clinical trials....