Metabolic Clearance Rate 2,055 articles
Dietary protein as a risk factor in gentamicin nephrotoxicity.
Our findings indicate that conditioning to higher dietary protein prior to gentamicin administration results in less uptake of gentamicin by the kidneys. If rats on HP diets are placed on LP coincident with gentamicin administration, there is a significant improvement in survival. Switching rats fro...
Diabinese-Dialume: a potential catastrophe.
We provide recommendations regarding therapy, bedside glucose monitoring, and prevention....
Pharmacokinetics of phenytoin in acute adult and child intoxication.
We suggest that these kinetic parameters for phenytoin probably are independent of age....
Symptomatic hyponatremia: pathophysiology and management.
We believe that the osmotic difference between the brain cell and the extracellular fluid is the critical parameter in determining therapy. A gradient of 30 mosm/kg or more produces significant shifts of intracellular water and cell damage. Seizure and coma are the neurologic signs associated with a...
Plasma levels of tricyclic antidepressants in panic disorder.
Five patients with panic disorder were placed on low doses of imipramine. All patients had shown dramatic improvement after three weeks of treatment, when plasma levels of imipramine and desipramine were measured. Plasma levels corresponded to the low doses being administered. This result implies th...
Is flunarizine a long-acting oral atypical antipsychotic? A randomized clinical trial versus haloperidol for the treatment of schizophrenia.
Flunarizine is known as a nonspecific calcium channel blocker that has been used for decades for the treatment of migraine, vertigo, and cognitive deficits related to cerebrovascular disorders. Flunarizine also has dopamine D2 receptor blocking properties and was effective in animal...
Enzyme-linked immunosorbent assay of carbamoylphosphate synthetase I: plasma enzyme in rat experimental hepatitis and its clearance.
We developed a sensitive enzyme-linked immunosorbent assay (ELISA) for measurement of the enzyme in plasma using an antibody against the rat enzyme. In galactosamine-induced rat acute hepatitis, plasma concentration of CPS I that was 1-2 micrograms/ml blood before the treatment, increased up to 125...
Managing rapid metabolizers of antidepressants.
Depressed patients who rapidly metabolize antidepressants may be common, and may not respond to even high doses of antidepressants if subtherapeutic plasma levels are produced. Rapid metabolizers (RMs) are identifiable if patients are on tricyclic antidepressants (TCAs), and TCA plasma levels (commo...
Biomarker amplification by serum carrier protein binding.
Mass spectroscopic analysis of the low molecular mass (LMM) range of the serum/plasma proteome is a rapidly emerging frontier for biomarker discovery. This study examined the proportion of LMM biomarkers, which are bound to circulating carrier proteins. Mass spectroscopic analysis of human serum fol...
Chromone-2-carboxylic acids: roles of acidity and lipophilicity in drug disposition. FAU - Smith, D A