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Metabolic Clearance Rate 2,055 articles

  1. Plasma levels of tricyclic antidepressants in panic disorder.

    International Journal of Psychiatry in Medicine 13(2):93 (1983) PMID 6642878

    Five patients with panic disorder were placed on low doses of imipramine. All patients had shown dramatic improvement after three weeks of treatment, when plasma levels of imipramine and desipramine were measured. Plasma levels corresponded to the low doses being administered. This result implies th...
  2. Symptomatic hyponatremia: pathophysiology and management.

    Acute care 14-15:270 (1988) PMID 3155033

    We believe that the osmotic difference between the brain cell and the extracellular fluid is the critical parameter in determining therapy. A gradient of 30 mosm/kg or more produces significant shifts of intracellular water and cell damage. Seizure and coma are the neurologic signs associated with a...
  3. Diabinese-Dialume: a potential catastrophe.

    Uremia investigation 8(2):135 (1984) PMID 6537686

    We provide recommendations regarding therapy, bedside glucose monitoring, and prevention....
  4. Dietary protein as a risk factor in gentamicin nephrotoxicity.

    Renal Failure 10(3-4):153 (1987) PMID 3504004

    Our findings indicate that conditioning to higher dietary protein prior to gentamicin administration results in less uptake of gentamicin by the kidneys. If rats on HP diets are placed on LP coincident with gentamicin administration, there is a significant improvement in survival. Switching rats fro...
  5. Enzyme-linked immunosorbent assay of carbamoylphosphate synthetase I: plasma enzyme in rat experimental hepatitis and its clearance.

    Enzyme & protein 48(4):213 (1994) PMID 8821709

    We developed a sensitive enzyme-linked immunosorbent assay (ELISA) for measurement of the enzyme in plasma using an antibody against the rat enzyme. In galactosamine-induced rat acute hepatitis, plasma concentration of CPS I that was 1-2 micrograms/ml blood before the treatment, increased up to 125...
  6. Pharmacokinetics of phenytoin in acute adult and child intoxication.

    Journal of Toxicology: Clinical Toxicology 24(6):519 (1986) PMID 3573125

    We suggest that these kinetic parameters for phenytoin probably are independent of age....
  7. Managing rapid metabolizers of antidepressants.

    Depression and Anxiety (Hoboken) 4(6):320 (1996) PMID 9166660

    Depressed patients who rapidly metabolize antidepressants may be common, and may not respond to even high doses of antidepressants if subtherapeutic plasma levels are produced. Rapid metabolizers (RMs) are identifiable if patients are on tricyclic antidepressants (TCAs), and TCA plasma levels (commo...
  8. Is flunarizine a long-acting oral atypical antipsychotic? A randomized clinical trial versus haloperidol for the treatment of schizophrenia.

    Journal of Clinical Psychiatry 69(10):1572 (2008) PMID 19192440

    Flunarizine is known as a nonspecific calcium channel blocker that has been used for decades for the treatment of migraine, vertigo, and cognitive deficits related to cerebrovascular disorders. Flunarizine also has dopamine D2 receptor blocking properties and was effective in animal...
  9. Biomarker amplification by serum carrier protein binding.

    Disease Markers 19(1):1 (2003) PMID 14757941

    Mass spectroscopic analysis of the low molecular mass (LMM) range of the serum/plasma proteome is a rapidly emerging frontier for biomarker discovery. This study examined the proportion of LMM biomarkers, which are bound to circulating carrier proteins. Mass spectroscopic analysis of human serum fol...
  10. Chromone-2-carboxylic acids: roles of acidity and lipophilicity in drug disposition. FAU - Smith, D A

    Drug Metabolism Reviews 16(4):365 (1985) PMID 3915471