Metabolic Diseases 5,196 articles
- Acid-Base Imbalance
- Brain Diseases, Metabolic
- Calcium Metabolism Disorders
- DNA Repair-Deficiency Disorders
- Glucose Metabolism Disorders
- Iron Metabolism Disorders
- Lipid Metabolism Disorders
- Malabsorption Syndromes
[Somatic factors in cognitive impairment].
Mild cognitive impairment describes a cognitive decline greater than expected for an individual's age and education level that does not interfere significantly with activities of daily life. In the recent years concepts of "mild cognitive impairment" with divergent definitions have been discussed as...
Mass spectrometry in newborn and metabolic screening: historical perspective and future directions.
The growth of mass spectrometry (MS) in clinical chemistry has primarily occurred in two areas: the traditional clinical chemistry areas of toxicology and therapeutic drug monitoring and more recent, human genetics and metabolism, specifically inherited disorders of intermediary metabolism and newbo...
Lithium: updated human knowledge using an evidence-based approach: part III: clinical safety.
We have reviewed existing (and especially recent) data on lithium efficacy and updated basic knowledge regarding the practical fundamentals of lithium therapy. The present paper reviews safety data on lithium available to date. Gastrointestinal pain or discomfort, diarrhoea, tremor, polyuria, noctur...
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes.
We investigated changes in the serum metabolome prospectively in children who later progressed to type 1 diabetes. Serum metabolite profiles were compared between sample series drawn from 56 children who progressed to type 1 diabetes and 73 controls who remained nondiabetic and permanently autoantib...
Metabolic and cardiovascular effects of androgen deprivation therapy.
We comprehensively reviewed previous reports using Medline searches of English-language literature (1950 to the present), with the keywords 'hypogonadism', 'testosterone', 'androgen deprivation therapy', 'hormonal treatment', 'prostate cancer', 'diabetes', 'metabolic syndrome', and 'cardiovascular d...
Developmental origins of adult metabolic disease.
[Hypertransaminasemia in an adolescent].
CASE REPORT: An adolescent admitted to hospital because of an obvious convulsion seizure presented with a high level of serum macroaspartate aminotransferase. This macroaspartate aminotransferase was discovered by chance when blood tests were made. DISCUSSION: Macroaspartate aminotransferase is a pe...
Valproate-induced biochemical abnormalities in pregnancy corrected by vitamins: a case report.
Valproate (VPA) is a teratogenic anticonvulsant (AED), but vitamin supplementation has been suggested to limit the effect of VPA on the fetus. Maternal urinary metabolites were monitored to assess the metabolic effects of VPA before and after vitamin supplementation....
Profiles of the Endocrine Clinic: the Mayo Clinic.
We believe that as the pace of knowledge regarding basic mechanisms of disease and their treatment quickens, such integrated divisions will prove well suited to deliver the highest quality care to people with endocrine disorders....
Intractable diseases and bone marrow transplantation.
Intractable diseases are defined as diseases of unknown etiopathogenesis, and for which therapeutic strategies remain to be established. They are therefore likely to cause various sequelae. Of the 86 intractable diseases recognized by the Ministry of Health and Welfare of Japan, half are thought to...