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Naphthoquinones 323 articles


  1. Lactones and quinones from the tubers of Sinningia aggregata.

    Journal of Natural Products 73(8):1434 (2010) PMID 20684540

    Three new aromatic epsilon-lactones, aggregatins A (1), B (2), and C (3), a new naphthoquinone derivative, aggregatin D (4), and three known anthraquinones, 2-methylanthraquinone, 7-methoxy-2-methylanthraquinone, and 7-hydroxy-2-methylanthraquinone, were isolated from the tubers of Sinningia aggrega...
  2. Total synthesis of the diazobenzofluorene antibiotic (-)-kinamycin C1.

    Journal of the American Chemical Society 128(46):14790 (2006) PMID 17105273

    The enantioselective total synthesis of the diazobenzofluorene antibiotic (-)-kinamycin C is reported. The approach involves tartrate-mediated, asymmetric nucleophilic epoxidation of a functionalized quinone monoketal to construct the highly substituted D-ring.
  3. [Determination of plumbagin in different parts of Plumbago zeylanica by RP-HPLC].

    China Journal of Chinese Materia Medica 31(20):1684 (2006) PMID 17225534

    OBJECTIVE: To develop a RP-HPLC method to determine plumbagin in Plumbago zeylanica, and to investigate contents of plumbagin in different parts of. P. zeylanica. METHOD: The analysis was carried out at 30 degrees C on a Kromasil C18, column eluted with a mobile phase consisting of a mixture of meth...
  4. Neuroprotection in the MPTP Parkinsonian C57BL/6 mouse model by a compound isolated from tobacco.

    Chemical Research in Toxicology 14(5):523 (2001) PMID 11368550

    These results support the hypothesis that the inhibition of MAO by constituents of tobacco smoke may be related to the decreased incidence of Parkinson's disease in smokers....
  5. 6-(1-alkenoyloxyalkyl)-5,8-dimethoxy-1,4-naphthoquinone derivatives:synthesis and evaluation of antitumor activity.

    Archives of Pharmacal Research 21(6):738 (1998) PMID 9868548

    Thirty six 5,8-dimethoxy-1,4-naphthoquinone derivatives, which bear unsaturated alkyl side chain with ester bond, were synthesized and tested cytotoxic activity on L1210 cells and antitumor activity against ICR mice bearing S-180 cells. It could be recognized that the cytotoxicities of naphthoquinon...
  6. Measurement of cofactor distances between P700.+ and A1.- in native and quinone-substituted photosystem I using pulsed electron paramagnetic...

    Biochemistry (Washington) 36(32):9774 (1997) PMID 9245409

    I and in preparations in which the native acceptor (vitamin K1) is replaced by different quinones is investigated by pulsed EPR spectroscopy. In a two-pulse experiment, the light-induced radical pair causes an out-of-phase electron spin echo, showing an envelope modulation. From the modulation frequ...
  7. Purpuromycin: an antibiotic inhibiting tRNA aminoacylation.

    RNA 3(8):905 (1997) PMID 9257649 PMCID 1369535

    We demonstrate that the mechanism of action of this antibiotic is quite novel in that it binds with fairly high affinity to all tRNAs, inhibiting their acceptor capacity. Although more than one molecule of purpuromycin is bound to each tRNA molecule, the inhibitory activity of this antibiotic was fo...
  8. Use of allylic strain to enforce stereochemistry. Direct syntheses of 7,8-dihydroxycalamenene and mansonone C.

    Organic Letters 8(23):5315 (2006) PMID 17078706 PMCID 1989682

  9. Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-kappaB-dependent XIAP up-regulation.

    Journal of Biological Chemistry 279(23):24015 (2004) PMID 15044484

    We established a cell model system to examine whether stable expression of Cyr61 in MCF-7 cells can confer resistance to apoptosis and identify possible participating mechanisms. We showed that stable cell lines overexpressing Cyr61 had acquired a remarkable resistance to apoptosis induced by paclit...
  10. Efficacy and safety of atovaquone/proguanil compared with mefloquine for treatment of acute Plasmodium falciparum malaria in Thailand.

    American Journal of Tropical Medicine and Hygiene 60(4):526 (1999) PMID 10348224

    The increasing frequency of therapeutic failures in falciparum malaria underscores the need for novel, rapidly effective antimalarial drugs or drug combinations. Atovaquone and proguanil are blood schizonticides that demonstrate synergistic activity against multi-drug-resistant Plasmodium falciparum...