Peptides 59,236 articles
- Antimicrobial Cationic Peptides
- Aptamers, Peptide
- Diazepam Binding Inhibitor
- Fibrinopeptide A
- Fibrinopeptide B
- Intercellular Signaling Peptides and Proteins
- Intracellular Signaling Peptides and Proteins
- Myocardial Depressant Factor
Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery.
We report the development of high-throughput assays that quantify the binding of bromodomains to acetylated histone peptides. We have used these assays to screen for histone binding partners of as yet uncharacterized bromodomains, adding to current knowledge of the histone code and expanding the rep...
[A possible effect of the immunomodulating therapy with beta-interferons and glatimer acetate on the development of thyroid disease in patie...
We present the own data on thyroid function in 191 patients managed in the Central administrative okrug of Moscow and in the Moscow Center for Multiple Sclerosis. Thyroid disease was found in 34.6% of patients (the formation of nodes and subclinical hypothyreosis). Changes in the thyroid function we...
Immuno-Expression of Human Melanoma Stem Cell Markers in Tissues at Different Stages of the Disease
Human cutaneous melanoma can be one of the most aggressive tumors and is extremely resistant to all current therapeutic modalities. Immunohistochemistry (IHC) studies were undertaken to assess independent relative frequency on preferential overexpression and simultaneous expression o...
Alpha2,3-Sialylation regulates the stability of stem cell marker CD133.
We found that CD133 could be sialylated in neural stem cells and glioma-initiating cells, and the sialyl residues attach to CD133 N-glycan terminal via alpha2,3-linkage. Furthermore, desialylation of CD133 by neuraminidase specifically accelerates its degradation in lysosomes-dependent pathway. Take...
[Effect of polypeptide extract from scorpion venom (PESV) on immune escape of Lewis lung carcinomas].
To study the effects of polypeptide extract from scorpion venom (PESV) on immune escape of Lewis lung carcinomas (LLC) and its mechanism. Forty C57BL/6J mice were inoculated with LLC cells suspension (1 x 10(7) cells/ mL) in right armpit subcutaneously. The tumor-bearing mice were randomly divided i...
Recoupling of native homonuclear dipolar couplings in magic-angle-spinning solid-state NMR by the double-oscillating field technique.
A new solid-state NMR method, the double-oscillating field technique (DUO), that under magic-angle-spinning conditions produces an effective Hamiltonian proportional to the native high-field homonuclear dipole-dipole coupling operator is presented. The method exploits one part of the...
68Ga-labelled exendin-3, a new agent for the detection of insulinomas with PET.
We investigated imaging of insulinomas with DOTA-conjugated exendin-3 labelled with (68)Ga. Targeting of insulinomas with [Lys(40)(DOTA)]exendin-3 labelled with either (111)In or (68)Ga was investigated in vitro using insulinoma tumour cells (INS-1). [Lys(40)((111)In-DTPA)]Exendin-3...
Newer agents for blood glucose control in type 2 diabetes: systematic review and economic evaluation.
In May 2008, the National Institute for Health and Clinical Excellence (NICE) issued an updated guideline [clinical guideline (CG) 66] for the management of all aspects of type 2 diabetes. This report aims to provide information on new drug developments to support a 'new drugs update...
One-pot electrosynthesis of polyglycine-like thin film on platinum electrodes as transducer for solid state pH measurements
We developed miniaturized microelectrodes on glass substrate thanks to photolithography process. We used silver chloride on silver as the reference electrode. The couple (silver chloride, PG based platinum electrode) of microelectrodes gives linear potentiometric response vs. pH in the range [2-12],...
Induction of apoptosis by gene transfer of human TRAIL mediated by arginine-rich intracellular delivery peptides.
We demonstrated that AID peptides were able to effectively deliver TRAIL gene into human lung carcinoma A549 cells. Soluble TRAIL-GFP protein purified from media after gene delivery was further evaluated regarding selective induction of apoptosis in cells. CONCLUSION: AID peptide-mediated DNA transf...