Advanced search×
×

All Neoplasms Precancerous Conditions

Precancerous Conditions 1,958 articles


  1. [Expression of P53 protein in premalignant lesion and carcinoma of larynx].

    Hua xi yi ke da xue xue bao = Journal of West C... 30(3):265 (1999) PMID 12212278

    To investigate the expression of P53 protein in the premalignant lesion and carcinoma of laryngeal epithelium, the authors used DO-7, an antibody to wild and mutant type P53 protein. Eleven cases of simple hyperplasia of epithelium (SHE), 32 cases of atypical hyperplasia of epithelium (AHE) and 42 c...
  2. Dietary copper, manganese and iron affect the formation of aberrant crypts in colon of rats administered 3,2'-dimethyl-4-aminobiphenyl.

    Journal of Nutrition 129(5):1060 (1999) PMID 10222400

    These results suggest that dietary alterations that affect superoxide dismutase activity may affect cancer susceptibility....
  3. Role of p53 gene mutations in human esophageal carcinogenesis: results from immunohistochemical and mutation analyses of carcinomas and near...

    Carcinogenesis 20(4):591 (1999) PMID 10223186

    We performed gene mutation and immunohistochemical analysis on 43 surgically resected human esophageal specimens, which contain squamous cell carcinoma (SCC) and adjacent non-cancerous lesions, from a high-incidence area of Linzhou in Henan, China. A newly developed immunohisto-selective sequencing...
  4. Fas-mediated apoptosis is attenuated in preneoplastic GST-P-positive hepatocytes isolated from diethylnitrosamine-treated rats.

    Cell Biology and Toxicology 15(4):239 (1999) PMID 10696823

    We have investigated the effects of an anti-Fas antibody (anti-Fas Ab) on EAF cells in vitro. Hepatocytes were isolated from rats treated repeatedly with diethylnitrosamine (DEN), whose livers contained glutathione S-transferase P (GST-P)-positive EAF. Subsequently, primary cultures of GST-P-positiv...
  5. Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke.

    JNCI Journal of the National Cancer Institute 91(1):60 (1999) PMID 9890171

    Diminished retinoid signaling, resulting from the suppression of RARbeta gene expression and overexpression of activator protein-1, could be a mechanism to enhance lung tumorigenesis after high-dose beta-carotene supplementation and exposure to tobacco smoke....
  6. Stem cell features of benign and malignant prostate epithelial cells.

    The Journal of Urology 160(6 Pt 2):2381 (1998) PMID 9817389

    We propose that topographic infidelity of proliferation produces a population of secretory cells replicating in the absence of key genome protective mechanisms, thus setting the stage for an accumulation of genomic alterations and instability in high grade prostatic intraepithelial neoplasia. This a...
  7. Inhibition of early-phase exogenous and endogenous liver carcinogenesis in transgenic rats harboring a rat glutathione S-transferase placent...

    Japanese Journal of Cancer Research 89(11):1118 (1998) PMID 9914780

    These results indicate that insertion of a rat GST-P transgene alters the early phase of exogenous and endogenous rat hepatocarcinogenesis, presumably due to enhanced detoxification by GST-P expressed both transiently during the initiation and chronically in the altered hepatocyte populations....
  8. Differential diagnosis of glandular proliferations in the prostate. A conventional and immunohistochemical approach.

    Virchows Archiv 433(5):397 (1998) PMID 9849853

    A variety of small acinar lesions of the prostate can mimic prostate cancer in punch biopsies and in transurethral resection material. The first part of this review deals with differential diagnostic problems of the central and transition zone, including atypical adenomatous hyperplasia of the prost...
  9. Near-infrared Raman spectroscopy for in vitro detection of cervical precancers.

    Photochemistry and Photobiology 68(1):123 (1998) PMID 9679458

    We investigate the potential of near-infrared Raman spectroscopy to differentiate cervical precancers from normal tissues, inflammation and metaplasia and to differentially diagnose low-grade and high-grade precancers. Near infrared Raman spectra were measured from 36 biopsies from 18 patients in vi...
  10. Expression of Bcl-X(L), an antiapoptotic member of the Bcl-2 family, in esophageal squamous cell carcinoma.

    Clinical Cancer Research 4(3):577 (1998) PMID 9533524

    Bcl-X, a Bcl-2-related protein, is a potent antagonist of apoptosis in its long splice variant (Bcl-X(L)). The present study was performed to determine its expression in preneoplastic and neoplastic lesions of the esophagus, its correlation with other members of the Bcl-2 family, and its impact on t...