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All Chemical Actions and Uses Pharmacologic Actions Physiological Effects of Drugs Protective Agents

Protective Agents 244 articles


  1. Terutroban, a thromboxane/prostaglandin endoperoxide receptor antagonist, increases survival in stroke-prone rats by preventing systemic inf...

    Journal of Pharmacology and Experimental Therap... 334(1):199 (2010) PMID 20332187

    This study investigated the efficacy of terutroban, a specific thromboxane/prostaglandin endoperoxide receptor antagonist, on stroke incidence in spontaneously hypertensive stroke-prone rats (SHRSP). The effects of terutroban were compared with those of aspirin, another antiplatelet...
  2. [Protective effect of peptide semax the rat heart in acute myocardial infarction].

    Rossiiskii fiziologicheskii zhurnal imeni I.M. ... 92(6):732 (2006) PMID 16967870

    We suggested that semax is also able to protect rat heart from ischemic damage in acute myocardial infaction (AMI). AMI was induced by left coronary artery occlusion, myocardial ischemic area averaged 30 % of left ventricle. In 2 hours after coronary occlusion, the AMI group developed 11 % reduced m...
  3. [Protective effect of human decay accelerating factor on mouse cells].
    Y Zhao, Li, and Y Fu

    Zhonghua Yixue Zazhi 81(24):1523 (2001) PMID 16200781

    The mouse cells containing human DAF cDNA and expressing human DAF survived for more than 48 hours and passed on from generation to generation in the culture medium containing human normal serum. However, the control mouse cells died in 1 - 4 hours. CONCLUSION: Human DAF protects mouse cells from in...
  4. The effect of tetrandrine and extracts of Centella asiatica on acute radiation dermatitis in rats.

    Biological & Pharmaceutical Bulletin 22(7):703 (1999) PMID 10443466

    We designed this study using Sprague-Dawley rats to evaluate the reduction in skin injury achieved using natural products from plant extracts as protection. The acute skin reaction in tetrandrine- and Madecassol-treated animals appeared earlier, but was significantly less severe, than in the control...
  5. Corrosive effects from the deposition of gaseous pollutants on surfaces of cultural and artistic value inside museums.

    Journal of Hazardous Materials 64(1):21 (1999) PMID 10337391

    The objectives of the project were to assess the critical relationships between environmental factors and damage of the artifacts and other cultural property exposed inside museums, by studying: (a) the outdoor/indoor pollutant concentration and their transfer inside the museum; (b) the distribution...
  6. Biscuit melanoidins of different molecular masses protect human HepG2 cells against oxidative stress.

    Journal of Agricultural and Food Chemistry 57(16):7250 (2009) PMID 20349918

    Soluble melanoidins from biscuits were enzymatically solubilized and isolated by sequential ultrafiltration and separated by molecular mass in three different fractions, below 3 kDa, between 3 and 10 kDa, and over 10 kDa; the latter was subsequently digested by simulating gastric plus pancreatic dig...
  7. [Protective effects of triterpenoids on primarily cultured rat hepatocytes injured by D-galactosamine and carbon tetrachloride].

    Zhejiang da xue xue bao. Yi xue ban = Journal o... 36(3):247 (2007) PMID 17571307

    AST and LDH in medium were decreased when treated with AA and GA after D-GalN injury (P<0.05). Moreover, AA and GA significantly reduced ROS and NOx generation, and ameliorated DeltaPsim lost induced by D-GalN. AA also inhibited GSH decrease...
  8. Effect of adhesive retention of maxillofacial prostheses. Part 2: Time and reapplication effects

    The Journal of Prosthetic Dentistry 85(5):4 (2001) PMID 11357068

    Bond strengths for both single applications and reapplications of the adhesive were greater at 0 hours and became significantly weaker after the 4- and 8-hour periods. The second application of the adhesive produced the strongest bonds when measured at 4 hours (110 N/m). Bonding was significantly hi...
  9. Complications of nonsteroidal antiiflammatory drug gastropathy and use of gastric cytoprotection: experience at a tertiary care health cente...

    Physician's First Watch 26(7):1557 (1999) PMID 10405945

    A total of 296 cases were identified. Use of NSAID was a contributing factor in 24% of patients admitted with upper GI bleeding, ulcer perforation, or gastric outlet obstruction. Use of ASA was a contributing factor in 25%. A true indication for NSAID/ASA use was identified in only 55% of cases. Fif...
  10. Effect of vitamin E in gastric mucosal injury induced by ischaemia-reperfusion in nitric oxide-depleted rats.

    Alimentary Pharmacology and Therapeutics 13(4):553 (1999) PMID 10215742

    The total area of erosions was significantly increased in the vitamin E-deficient group compared with the sufficient-intake and vitamin-supplemented groups. Both thiobarbituric acid-reactive substances and myeloperoxidase activity also were significantly increased in the vitamin E-deficient group co...