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All Nervous System Diseases Autoimmune Diseases of the Nervous System Stiff-Person Syndrome

Stiff-Person Syndrome 67 articles


  1. Rigidity and spasms from autoimmune encephalomyelopathies: stiff-person syndrome.

    Muscle & Nerve 34(6):677 (2006) PMID 16969837

    Stiff-person syndrome (SPS) is a disorder characterized by progressive muscle rigidity with superimposed painful muscle spasms and gait impairment due to continuous motor activity. Evidence has accumulated in favor of SPS representing an autoimmune, predominantly encephalomyelopathic disorder result...
  2. Intrathecal baclofen therapy for stiff-man syndrome and progressive encephalomyelopathy with rigidity and myoclonus.

    Neurology 49(6):1591 (1997) PMID 9409352

    We report on eight patients with stiff-man syndrome (SMS) or its "plus" variant, progressive encephalomyelopathy with rigidity and myoclonus (PERM) receiving intrathecal baclofen via pump. In six of the patients, follow-ups continued for approximately 2.5 to 6.5 years after pump implantation. Intrat...
  3. Stiff-man syndrome in a woman with breast cancer: an uncommon central nervous system paraneoplastic syndrome.

    Neurology 50(1):94 (1998) PMID 9443464

    We report a patient who developed stiff-man syndrome, including disabling shoulder subluxation and wrist ankylosis, in association with breast cancer. Immunologic investigations disclosed autoimmunity directed against not only glutamic acid decarboxylase but also amphiphysin, a 128-kd protein locate...
  4. [Autoantibodies against GAD and GAD65].

    Nippon rinsho. Japanese journal of clinical med... 56 Suppl 3:190 (1998) PMID 9513413

  5. [Unusual causes of gait disorders].

    Revue medicale de la Suisse romande 123(1):63 (2003) PMID 15095729

    We believe that a better knowledge of these unusual forms of gait disorder may allow general practitioners to identify them more accurately, to assess them and to improve therapeutic strategies....
  6. Stiff person syndrome.

    The Journal of the Association of Physicians of... 49:568 (2001) PMID 11361276

    This communication considers a patient with episodic muscle spasms. Pharmacological intervention and electrophysiological studies provided adequate evidence confirming the diagnosis of stiff person syndrome. Electrophysiological studies in present communication similar to earlier reports, confirmed...
  7. Paraneoplastic stiff-person syndrome, heterotopic soft tissue ossification and gonarthritis in a HLA B27-positive woman preceding the diagno...

    Haematologica 91(12 Suppl):ECR59 (2006) PMID 17194665

    Paraneoplastic neurologic syndromes associated with Hodgkin's lymphoma include the stiff-person syndrome. A case of stiff-person syndrome is reported who first presented with muscular hyperactivity and acute respiratory failure followed by heterotopic soft tissue ossification and acute seronegative...
  8. [Botulinum toxin A in the treatment of stiff man syndrome].

    Neurologia i neurochirurgia polska 37 Suppl 5:175 (2003) PMID 15098344

    We investigated the effectiveness of intramuscular injections of BTA in a patient with clinical, biochemical and electrophysiological evidence of SPS. A 41-year-old woman with coexisting epilepsy and insulin-dependent diabetes mellitus was hospitalised in our Department because of stiffness and paro...
  9. Stiff-person syndromes: motor cortex hyperexcitability correlates with anti-GAD autoimmunity.

    Neurology 62(8):1357 (2004) PMID 15111674

    The motor cortex is hyperexcitable in SPS and PER patients. However, hyperexcitability is partly masked by GABAmimetic treatment. Correlation of elevated GAD antibody levels with enhanced ICF suggests that motor cortex hyperexcitability in SPS and PER is related to anti-GAD autoimmunity....
  10. Lupus revealing itself after a stiff-person syndrome.

    Lupus 13(3):215 (2004) PMID 15119554