Vibrissae 873 articles
Dynamic, experience-dependent modulation of synaptic zinc within the excitatory synapses of the mouse barrel cortex
We have previously shown manipulations of sensory input leads to rapid changes in synaptic zinc levels within the corresponding regions of the somatotopic map in the cortex. Here, using electron microscopy, we show how some of these changes are mediated at the synaptic level. We found that the densi...
A critical window for experience-dependent plasticity at whisker sensory relay synapse in the thalamus.
This study investigated the role of sensory experience in the refinement of whisker sensory relay synapses in the ventral posterior medial nucleus (VPm) of the murine thalamus. Sensory deprivation was done by whisker plucking, and synaptic connectivity was determined by whole-cell patch-clamp record...
Developmental and comparative aspects of posterior medial thalamocortical innervation of the barrel cortex in mice and rats.
We characterize the POm thalamocortical innervation of adult mouse barrel cortex and describe its early postnatal development in both mice and rats. In adult mice, POm inputs form a dense plexus in layer Va that extends uniformly underneath layer IV barrels and septa. Innervation of layer IV is very...
Embodied Information Processing: Vibrissa Mechanics and Texture Features Shape Micromotions in Actively Sensing Rats
We report the characterization of surface transduction during active sensing in the rodent vibrissa sensory system, a widely used model. Employing high-speed videography, we tracked vibrissae while rats sampled rough and smooth textures. Variation in vibrissa length predicted motion mean frequencies...
Stimulus dependence of barrel cortex directional selectivity.
Behavioural effects of parafascicular thalamic lesions in an animal model of parkinsonism
We recently reported that the centromedian-parafascicular thalamic complex (CM-Pf) degenerates in Parkinson's disease and progressive supranuclear palsy. The contribution of such thalamic pathology to disease symptoms has not yet been established. The present study therefore investigated the behavio...
Facial nerve injury produces a latent somatosensory input through recruitment of the motor cortex in the rat.
Short-latency effects of unilateral facial nerve transection were studied on neuronal activation evoked in the primary motor cortex (MI) on both sides by vibrissa stimulation in adult rats. In the controls, unilateral trigeminal stimulation evoked activity in the whisker representation of both the c...
Multiple promoters direct stimulus and temporal specific expression of brain-derived neurotrophic factor in the somatosensory cortex.
Our data show that specific promoters are utilized at different stages of the activity-dependent induction of the BDNF gene. Furthermore, the data show a differential utilization of the four promoters following a specific stimulus. Copyright 1998 Elsevier Science B.V....
Early assessment of motor dysfunctions aids in successful occlusion of the middle cerebral artery.
We demonstrate here sensitive and reliable behavioral parameters including the elevated body swing test, the postural tail-hang test, the spontaneous rotational test, and the forelimb akinesia test. These assays provide a criterion for identifying animals with incomplete occlusion which could promot...
Overlap of sensory representations in rat barrel cortex after neonatal vibrissectomy.
We examined if sparing of one mystacial vibrissa from the neonatal ablation, which results in a very extensive increase of its cortical representation, would prevent the invasion of the common fur inputs into the PMBSF. The cortical representations were mapped with 2-deoxyglucose (2DG). It was found...