Viruses 9,828 articles
- Archaeal Viruses
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The therapeutic potential of deubiquitinating enzyme inhibitors.
Proteases play a key role in various pathological processes and several protease inhibitors are already available for treatment. DUBs (deubiquitinating enzymes) constitute one of the largest classes of human proteases and are key effectors of the ubiquitin-proteasome system. This pathway regulating...
War and Peace between Microbes: HIV-1 Interactions with Coinfecting Viruses
Anatomy of viral persistence.
The Impact of Viral Respiratory Infection on the Severity and Recovery From an Asthma Exacerbation
Our objective was to evaluate the impact of a concurrent acute respiratory illness (based on a clinical definition and PCR detection of a panel of respiratory viruses, Mycoplasma pneumoniae and Chlamydia pneumoniae) on the severity and resolution of symptoms in children with a nonhospitalized exacer...
Filtered Z-closure supernetworks for extracting and visualizing recurrent signal from incongruent gene trees.
Comparative evaluation of viral, nonviral and physical methods of gene delivery to normal and transformed lung epithelial cells.
We report the first study directly comparing the efficiency and toxicity of viral [adeno-associated virus (AAV2, 5, 6) and lentivirus], nonviral (Effectene, SuperFect and Lipofectamine 2000) and physical [particle-mediated gene transfer (PMGT)] methods of gene delivery in normal mouse lung cells and...
Upper respiratory virus detection without parent-reported illness in children is virus-specific.
The frequency of PCR virus detection without CFLI was different among viruses. This introduces virus-specific biases to estimating the frequencies of specific complications attributable to a vURI when ascertained by CFLI identification....
Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice.
We defined the effects of CS on pathogen-associated molecular pattern-induced (PAMP-induced) pulmonary inflammation and remodeling in mice. CS was found to enhance parenchymal and airway inflammation and apoptosis induced by the viral PAMP poly(I:C). CS and poly(I:C) also induced accelerated emphyse...
Improvement of virus safety of an antihemophilc factor IX by virus filtration process.
These results indicate that the virus filtration process successfully improved the viral safety of factor IX....
New tools for the study and direct surveillance of viral pathogens in water
Half a century ago scientists attempted the detection of poliovirus in water. Since then other enteric viruses responsible for gastroenteritis and hepatitis have replaced enteroviruses as the main target for detection. However, most viral outbreaks are restricted to norovirus and hepatitis A virus,...