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Cholecystokinin (1):
Recent article
Cholecystokinin
Acta Physiologica (201)4 2011
Abstract
Gastrin and cholecystokinin (CCK) are homologous hormone systems known to regulate gastric acid secretion, gallbladder emptying, and cell growth in the pancreas and stomach. They are, however, also involved in the development and secretory functions of pancreatic islet cells. For ins...
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PMID: 21392266
PDF is available here.
PDF is available here.
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Acta Physiologica (201)4 2011
Abstract
Gastrin and cholecystokinin (CCK) are homologous hormone systems known to regulate gastric acid secretion, gallbladder emptying, and cell growth in the pancreas and stomach. They are, however, also involved in the development and secretory functions of pancreatic islet cells. For ins...
|
PMID: 21392266
PDF is available here.
PDF is available here.
Journal of Gastroenterology and Hepatology (26 Suppl 3) 2011
Abstract
The placebo effect has evolved from being considered a nuisance factor in clinical research to a hot topic of scientific investigation. New research findings show that a placebo has real psychobiological and biological effects that are attributable to the overall therapeutic context....
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PMID: 21751434
PDF is available here.
PDF is available here.
Acta Physiologica (201)1 2011
Abstract
We have investigated the effects of apelin peptides on duodenal bicarbonate secretion in vivo and the release of cholecystokinin (CCK) from acutely isolated mucosal cells and the neuroendocrine cell line STC-1.
Lewis × Dark Agouti rats had free access to water and, unless fasted ove...
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PMID: 20726845
PDF is available here.
PDF is available here.
Abstract
Although energy balance is tightly regulated in order to maintain a specific level of adiposity, the incidence of obesity continues to increase. Consequently, it is essential that effective therapeutics for the treatment and prevention of obesity be developed. This review provides a...
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PMID: 20585249
PDF is available here.
PDF is available here.
Abstract
We investigated the changes of myoelectric activity in rabbits with chronic cholangitis in vivo and in vitro.
Chronic cholangitis was induced in rabbits by initially introducing three pieces of 2-0 silk suture and sequentially injecting E. coli into the choledochus through the tube in ductus cysticu...
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PMID: 20426800
PDF is available here.
PDF is available here.
Annals of Surgery (252)2 2010
Abstract
Deafferentation reversed the inhibitory effect of lipid-rich nutrition on systemic levels of tumor necrosis factor-alpha and interleukin-6, and on intestinal leakage of horseradish peroxidase and bacterial translocation. Furthermore, the protective effects of lipid-rich nutrition were negated by A70...
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PMID: 20585240
PDF is available here.
PDF is available here.
Abstract
We compared CCK-like immunoreactivity (CCK-LI) in plasma from 25 subjects in the late luteal phase (LLP) and the follicular phase (FP) and found that there was no difference during the menstrual cycle (n=25, R(2)=89.60%, p=n.s.). In the follicular phase no significant difference was found between CC...
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PMID: 20457200
PDF is available here.
PDF is available here.
Abstract
Although correlations were shown between energy intake and antropyloroduodenal pressures, plasma hormone concentrations, and gastrointestinal perceptions, only the peak number of isolated pyloric-pressure waves, peak plasma cholecystokinin concentration, and area under the curve of nausea were ident...
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PMID: 20484444
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)26 2010
Abstract
Perisomatic inhibition from basket cells plays an important role in regulating pyramidal cell output. Two major subclasses of CA1 basket cells can be identified based on their expression of either cholecystokinin (CCK) or parvalbumin. This study examined their fates in the mouse pilocarpine model of...
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PMID: 20592220
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)24 2010
Abstract
We describe an exception to this rule, in the form of granule cells that reside within the CA3 area and function as glutamatergic nonprincipal cells with distinct properties. CA3 granule cells in normal, healthy rats, similarly to dentate gyrus granule cells, coexpressed calbindin and the homeobox p...
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PMID: 20554881
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)23 2010
Abstract
We performed paired recordings from CCK-positive perisomatically (basket cells) or dendritically projecting (Schaffer collateral-associated cells) interneurons and postsynaptic CA1 pyramidal cells to determine the properties of endocannabinoid signaling at GABAergic synapses along the somato-dendrit...
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PMID: 20534847
PDF is available here.
PDF is available here.
Abstract
The most widely used pharmacological therapies for obesity and weight management are based on inhibition of gastrointestinal lipases, resulting in a reduced energy yield of ingested foods by reducing dietary lipid absorption. Colipase-dependent pancreatic lipase is believed to be the major gastroint...
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PMID: 20193096
PDF is available here.
PDF is available here.
Abstract
We investigated this response.
We investigated the involvement of the opioid system in the A(1)-adenosine acute withdrawal response in guinea-pig ileum, the potential induced cross-dependence between the A(1) and the opioid system and also the interaction between the CCk-8 and A(1) systems.
We found...
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PMID: 20609065
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)17 2010
Abstract
We tested the hypothesis that neurochemically distinct interneuron populations are differentially engaged by muscarinic acetylcholine receptor (mAChR) activation. Cholinergic fiber activation revealed that CCK BCs were more sensitive to synaptic release of ACh than PV BCs. In response to depolarizin...
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PMID: 20427660
PDF is available here.
PDF is available here.
Bioconjugate Chemistry (21)4 2010
Abstract
We describe the synthesis of stabilized sCCK8 analogues, resistant to hydrolysis and oxidation. Hydrolytic stability was achieved by replacement of the Tyr(OSO(3)H) moiety by a robust isosteric sulfonate, Phe(p-CH(2)SO(3)H). Replacement of methionine by norleucine (Nle) or homopropargylglycine (HPG)...
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PMID: 20302291
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)15 2010
Abstract
We examined the effects of CCK on glutamatergic transmission in the hippocampus using whole-cell recordings from hippocampal slices. Application of CCK increased AMPA receptor-mediated EPSCs at perforant path-dentate gyrus granule cell, CA3-CA3 and Schaffer collateral-CA1 synapses without effects at...
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PMID: 20392936
PDF is available here.
PDF is available here.
Psychiatric Genetics (20)2 2010
Abstract
The promoter variant (-36C > T; rs1799923) and an intron 1 polymorphism (IVS1-7C > G; rs754635) in the CCK gene were found to protect against PD (P<0.05). The intron 1 variation did not seem to alter the splicing of the gene. None of the other variations found were associated with PD, but a 2-marker...
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PMID: 20023595
PDF is available here.
PDF is available here.
Abstract
Abstract
We observed that SP- and CCK-immunoreactivity coexisted in a very low number of primary afferent neurons (2.7%). Few SP-immunoreactive (IR) neurons (2.7%) were also CCK-positive. On the contrary, 65% of CCK-immunoreactive neurons contained SP. Interestingly, we observed CCK-immunoreactive satellite...
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PMID: 20169567
PDF is available here.
PDF is available here.
Abstract
Both CCKR subtypes occupy RIN-14B cells and initiate SS secretion through constitutive secretion controlled at SS synthesis level. Somatostatin secretion via the CCK-1R occupation mobilizes its high-affinity sites....
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PMID: 19959964
PDF is available here.
PDF is available here.
Abstract
The current study sought to clarify the role of cholecystokinin (CCK) in the digestion of larval red drum (Sciaenops ocellatus) in order to better characterize the processes limiting the utilization of microparticulate diets at first feeding. The red drum CCK cDNA, isolated from adult anterior intes...
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PMID: 19896946
PDF is available here.
PDF is available here.
Abstract
We investigate these cells in the hippocampal area CA1 and show that they constitute ∼20% of interneurons in this area. The majority of them expresses either reelin (70±2%) or vasoactive intestinal peptide (VIP; 15±2%), while expression of parvalbumin and somatostatin is virtually absent. This s...
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PMID: 21209836
PDF is available here.
PDF is available here.
Abstract
The effects of the adrenocorticotropic hormone (ACTH(4-10)) analog, Semax (MEHFPGP), on the level of anxiety and depression in white rats have been studied in the normal state and against the background of cholecystokinin-tetrapeptide (CCK-4) action. Semax was injected intranasally in doses of 50 an...
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PMID: 20387390
PDF is available here.
PDF is available here.
Abstract
Cells Tissues Organs (191)4 2010
Abstract
We concluded that displaced neurons in the TNR morphologically and immunohistochemically resembled the sensory neurons in the trigeminal ganglion....
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PMID: 19923783
PDF is available here.
PDF is available here.
Abstract
Energy balance of the body is determined mainly by the function of various hypothalamic and brainstem nuclei, according to a complex interaction between the regulation of body temperature (actual metabolic rate vs. heat loss) and regulation of body weight (metabolic rate vs. food intake). The direct...
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PMID: 20515839
PDF is available here.
PDF is available here.
Abstract
Gastrin and cholecystokinin (CCK) are homologous hormones with important functions in the brain and the gut. Gastrin is the main regulator of gastric acid secretion and gastric mucosal growth, whereas cholecystokinin regulates gall bladder emptying, pancreatic enzyme secretion and besides acts as a...
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PMID: 19960379
PDF is available here.
PDF is available here.
Abstract
The singular gene for a peptide hormone is expressed not only in a specific endocrine cell type but also in other endocrine cells as well as in entirely different cells such as neurons, adipocytes, myocytes, immune cells, and cells of the sex-glands. The cellular expression pattern for each gene var...
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PMID: 19859674
PDF is available here.
PDF is available here.
Behavioral Neuroscience (123)6 2009
Abstract
We hypothesized that the anxiolytic effect of MS15 is partly due to increased intestinal release of cholecystokinin (CCK) in rat pups as a result of increased maternal contact. We predicted that rats with a history of MS15 would display less anxiety in the elevated plus maze (EPMZ) and novelty-suppr...
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PMID: 20001102
PDF is available here.
PDF is available here.
Abstract
We aimed to determine occurrence and putative pathomechanisms of gastric motor disorders in such patients. Thirteen healthy subjects (CON), 13 patients with Crohn's disease (CD), 10 with ulcerative colitis (UC), and 7 with diverticulitis (DIV) underwent a standardized (13)C-octanoic acid gastric emp...
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PMID: 20501434
PDF is available here.
PDF is available here.
Abstract
Classic biliary symptoms are more predictive of success after cholecystectomy in patients with GD than is EF. The symptoms that are most predictive of success after surgery are right upper quadrant pain, pain after meals, and reproduction of the pain after CCK administration. Patients with atypical...
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PMID: 19542850
PDF is available here.
PDF is available here.
Cell Calcium (45)6 2009
Abstract
Pancreatitis, a potentially fatal disease in which the pancreas digests itself as well as its surroundings, is a well recognized complication of hyperlipidemia. Fatty acids have toxic effects on pancreatic acinar cells and these are mediated by large sustained elevations of the cytos...
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PMID: 19327825
PDF is available here.
PDF is available here.
Cell Calcium (45)6 2009
Abstract
Pancreatitis, a potentially fatal disease in which the pancreas digests itself as well as its surroundings, is a well recognized complication of hyperlipidemia. Fatty acids have toxic effects on pancreatic acinar cells and these are mediated by large sustained elevations of the cytos...
|
PMID: 19327825
PDF is available here.
PDF is available here.
Cell Calcium (45)6 2009
Abstract
Pancreatitis, a potentially fatal disease in which the pancreas digests itself as well as its surroundings, is a well recognized complication of hyperlipidemia. Fatty acids have toxic effects on pancreatic acinar cells and these are mediated by large sustained elevations of the cytos...
|
PMID: 19327825
PDF is available here.
PDF is available here.
Cell Calcium (45)6 2009
Abstract
Pancreatitis, a potentially fatal disease in which the pancreas digests itself as well as its surroundings, is a well recognized complication of hyperlipidemia. Fatty acids have toxic effects on pancreatic acinar cells and these are mediated by large sustained elevations of the cytos...
|
PMID: 19327825
PDF is available here.
PDF is available here.
Cell Calcium (45)6 2009
Abstract
Pancreatitis, a potentially fatal disease in which the pancreas digests itself as well as its surroundings, is a well recognized complication of hyperlipidemia. Fatty acids have toxic effects on pancreatic acinar cells and these are mediated by large sustained elevations of the cytos...
|
PMID: 19327825
PDF is available here.
PDF is available here.
Cell Calcium (45)6 2009
Abstract
Pancreatitis, a potentially fatal disease in which the pancreas digests itself as well as its surroundings, is a well recognized complication of hyperlipidemia. Fatty acids have toxic effects on pancreatic acinar cells and these are mediated by large sustained elevations of the cytos...
|
PMID: 19327825
PDF is available here.
PDF is available here.
Cell Calcium (45)6 2009
Abstract
Pancreatitis, a potentially fatal disease in which the pancreas digests itself as well as its surroundings, is a well recognized complication of hyperlipidemia. Fatty acids have toxic effects on pancreatic acinar cells and these are mediated by large sustained elevations of the cytos...
|
PMID: 19327825
PDF is available here.
PDF is available here.
Cell Calcium (45)6 2009
Abstract
Pancreatitis, a potentially fatal disease in which the pancreas digests itself as well as its surroundings, is a well recognized complication of hyperlipidemia. Fatty acids have toxic effects on pancreatic acinar cells and these are mediated by large sustained elevations of the cytos...
|
PMID: 19327825
PDF is available here.
PDF is available here.
Abstract
Gastric myoelectrical activity in type 2 diabetics is impaired on dominant frequency, dominant frequency instability coefficient, and the percentage of bradygastria and predicted by body mass index, fasting serum leptin level, and cholecystokinin mRNA content besides the glycemic status....
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PMID: 19564814
PDF is available here.
PDF is available here.
British Journal of Nutrition (101)7 2009
Abstract
Gastric emptying, as well as intragastric meal distribution, and gastrointestinal hormones, including cholecystokinin (CCK), play an important role in appetite regulation. The evaluation of gastrointestinal factors regulating food intake is commonly performed in healthy, lean, young male participant...
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PMID: 18680633
PDF is available here.
PDF is available here.
International Journal of Obesity (33 Suppl 1) 2009
Abstract
We consider one such alternative, namely, that a specialized group of CNS structures collectively known as the sensory circumventricular organs (CVOs), which are not protected by the normal blood-brain barrier, may play important roles in such blood to brain communications. Specifically, we review a...
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PMID: 19363501
PDF is available here.
PDF is available here.
International Journal of Obesity (33 Suppl 1) 2009
Abstract
Multiple gut peptides are involved in the overall control of food intake. Plasma levels of gut peptides are differentially affected by food intake, and the different patterns of release around meals provides an indication of a peptide's specific role in feeding control. Ghrelin is a gastric peptide...
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PMID: 19363513
PDF is available here.
PDF is available here.
International Journal of Obesity (33 Suppl 1) 2009
Abstract
Abstract
We covalently coupled CCK to a 10kDa polyethylene glycol (mPEG-OH) and showed that this conjugate, PEG-CCK(9), produced a significantly longer anorectic effect than unmodified CCK(9). The present study examined whether tolerance to the anorectic effect develops during long-term administration of PEG...
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PMID: 19084041
PDF is available here.
PDF is available here.
Abstract
We covalently coupled CCK to a 10kDa polyethylene glycol (mPEG-OH) and showed that this conjugate, PEG-CCK(9), produced a significantly longer anorectic effect than unmodified CCK(9). The present study examined whether tolerance to the anorectic effect develops during long-term administration of PEG...
|
PMID: 19084041
PDF is available here.
PDF is available here.
Abstract
We covalently coupled CCK to a 10kDa polyethylene glycol (mPEG-OH) and showed that this conjugate, PEG-CCK(9), produced a significantly longer anorectic effect than unmodified CCK(9). The present study examined whether tolerance to the anorectic effect develops during long-term administration of PEG...
|
PMID: 19084041
PDF is available here.
PDF is available here.
Abstract
We covalently coupled CCK to a 10kDa polyethylene glycol (mPEG-OH) and showed that this conjugate, PEG-CCK(9), produced a significantly longer anorectic effect than unmodified CCK(9). The present study examined whether tolerance to the anorectic effect develops during long-term administration of PEG...
|
PMID: 19084041
PDF is available here.
PDF is available here.
Abstract
BC-264 a CCK(2) agonist reverses chronically developed habituated predatory fear freezing behavior in PVG hooded rats. However, the acute effects of BC264 have not been previously examined. The effects of BC-264 (0.1-30microg/kg) on the mean percentage of PVG hooded rat freezing duri...
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PMID: 19150473
PDF is available here.
PDF is available here.
Abstract
BC-264 a CCK(2) agonist reverses chronically developed habituated predatory fear freezing behavior in PVG hooded rats. However, the acute effects of BC264 have not been previously examined. The effects of BC-264 (0.1-30microg/kg) on the mean percentage of PVG hooded rat freezing duri...
|
PMID: 19150473
PDF is available here.
PDF is available here.
Abstract
BC-264 a CCK(2) agonist reverses chronically developed habituated predatory fear freezing behavior in PVG hooded rats. However, the acute effects of BC264 have not been previously examined. The effects of BC-264 (0.1-30microg/kg) on the mean percentage of PVG hooded rat freezing duri...
|
PMID: 19150473
PDF is available here.
PDF is available here.
Abstract
We covalently coupled CCK to a 10kDa polyethylene glycol (mPEG-OH) and showed that this conjugate, PEG-CCK(9), produced a significantly longer anorectic effect than unmodified CCK(9). The present study examined whether tolerance to the anorectic effect develops during long-term administration of PEG...
|
PMID: 19084041
PDF is available here.
PDF is available here.
Abstract
BC-264 a CCK(2) agonist reverses chronically developed habituated predatory fear freezing behavior in PVG hooded rats. However, the acute effects of BC264 have not been previously examined. The effects of BC-264 (0.1-30microg/kg) on the mean percentage of PVG hooded rat freezing duri...
|
PMID: 19150473
PDF is available here.
PDF is available here.
Abstract
BC-264 a CCK(2) agonist reverses chronically developed habituated predatory fear freezing behavior in PVG hooded rats. However, the acute effects of BC264 have not been previously examined. The effects of BC-264 (0.1-30microg/kg) on the mean percentage of PVG hooded rat freezing duri...
|
PMID: 19150473
PDF is available here.
PDF is available here.
Abstract
We covalently coupled CCK to a 10kDa polyethylene glycol (mPEG-OH) and showed that this conjugate, PEG-CCK(9), produced a significantly longer anorectic effect than unmodified CCK(9). The present study examined whether tolerance to the anorectic effect develops during long-term administration of PEG...
|
PMID: 19084041
PDF is available here.
PDF is available here.
Abstract
BC-264 a CCK(2) agonist reverses chronically developed habituated predatory fear freezing behavior in PVG hooded rats. However, the acute effects of BC264 have not been previously examined. The effects of BC-264 (0.1-30microg/kg) on the mean percentage of PVG hooded rat freezing duri...
|
PMID: 19150473
PDF is available here.
PDF is available here.
Abstract
We covalently coupled CCK to a 10kDa polyethylene glycol (mPEG-OH) and showed that this conjugate, PEG-CCK(9), produced a significantly longer anorectic effect than unmodified CCK(9). The present study examined whether tolerance to the anorectic effect develops during long-term administration of PEG...
|
PMID: 19084041
PDF is available here.
PDF is available here.
Abstract
BC-264 a CCK(2) agonist reverses chronically developed habituated predatory fear freezing behavior in PVG hooded rats. However, the acute effects of BC264 have not been previously examined. The effects of BC-264 (0.1-30microg/kg) on the mean percentage of PVG hooded rat freezing duri...
|
PMID: 19150473
PDF is available here.
PDF is available here.
Abstract
We covalently coupled CCK to a 10kDa polyethylene glycol (mPEG-OH) and showed that this conjugate, PEG-CCK(9), produced a significantly longer anorectic effect than unmodified CCK(9). The present study examined whether tolerance to the anorectic effect develops during long-term administration of PEG...
|
PMID: 19084041
PDF is available here.
PDF is available here.