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Diazepam Binding Inhibitor (0):
Recent article
Diazepam Binding Inhibitor
New Phytologist (186)4 2010
Abstract
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Abstract
The role of cardiolipin acyl chain composition in assembly/stabilization of mitochondrial complexes was investigated using three yeast deletion mutants (acb1Delta strain; taz1Delta strain; and acb1Deltataz1Delta strain). Deletion of the TAZ1 gene, involved in cardiolipin acyl chain remodeling, is kn...
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PMID: 19944197
PDF is available here.
PDF is available here.
Abstract
We utilized the acyl-coenzyme A (CoA) binding protein (ACBP) as a molecular probe to detect radioactive long-chain acyl-CoA, a direct product of Elovl6. Recombinant ACBP binds stearoyl-CoA but not malonyl-CoA, enabling specific detection of the radioactive product in the homogenous reaction mixture...
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PMID: 19505229
PDF is available here.
PDF is available here.
Abstract
We utilized the acyl-coenzyme A (CoA) binding protein (ACBP) as a molecular probe to detect radioactive long-chain acyl-CoA, a direct product of Elovl6. Recombinant ACBP binds stearoyl-CoA but not malonyl-CoA, enabling specific detection of the radioactive product in the homogenous reaction mixture...
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PMID: 19505229
PDF is available here.
PDF is available here.
Abstract
Our results demonstrate that ACBP overexpression affects metabolic responses to diets with distinct difference in their fatty acid chain lengths. The molecular regulatory mechanism behind these effects seems to be an ACBP-induced tissue-specific regulation of expression of PPARs and SREBP....
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PMID: 18394026
PDF is available here.
PDF is available here.
Abstract
The negative control of pancreatic exocrine secretion in man occurs during the interdigestive and postprandial periods of the digestive cycle. The physiological mechanisms involved include negative feedback mechanisms, well described and accepted in animals, and controlled by the cholecystokinin- an...
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PMID: 18580437
PDF is available here.
PDF is available here.
Biology of the Cell (100)7 2008
Abstract
High-affinity ligand binding to mitochondrial TSPO modulates neurotransmitter-induced salivary secretion by duct and mucous acinar cells of rat submandibular glands....
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PMID: 18269350
PDF is available here.
PDF is available here.
Experimental Cell Research (314)10 2008
Abstract
We identified one of the phosphoproteins to be acyl-CoA binding protein (ACBP), a highly conserved and ubiquitously expressed protein. Phosphorylation-site analysis by matrix-assisted laser desorption ionization time-of-flight MS/MS revealed that the observed phosphorylation is positioned on Ser1 in...
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PMID: 18455725
PDF is available here.
PDF is available here.
Abstract
Acyl-CoA-binding protein (ACBP), also known as the diazepam-binding inhibitor (DBI), has been identified in diverse species and is evolutionarily conserved in plants and animals. In a recent study, an ACBP cDNA (HaACBP) encoding 85 amino acids was isolated from the cotton bollworm Helicoverpa armige...
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PMID: 18481302
PDF is available here.
PDF is available here.
Journal of Neurochemistry (105)4 2008
Abstract
We examine in vitro whether ACBP is secreted by Müller glial cells and Müller-like QNR/K2 cells following stimulation with elevated levels of KCl and phorbol myristic acetate (PMA). KCl and PMA stimulation evoked secretion of threonine-phosphorylated ACBP. A sequence analysis of ACBP shows that it...
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PMID: 18194441
PDF is available here.
PDF is available here.
Abstract
We created a transgenic rat line overexpressing ACBP, as the physiological relevance of ACBP in lipid metabolism is unclear. Transgenic rats revealed increased levels of ACBP and significantly elevated acyl-CoA tissue levels while there was no effect on plasma triglyceride, cholesterol, or serum-fre...
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PMID: 18157544
PDF is available here.
PDF is available here.
Abstract
Characterizing combinations of coding polymorphisms (cSNPs), alternative splicing and post-translational modifications (PTMs) on a single protein by standard peptide-based proteomics is challenging owing to <100% sequence coverage and the uncoupling effect of proteolysis on such variations >10-20 re...
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PMID: 18351787
PDF is available here.
PDF is available here.
Abstract
We analyzed this process by molecular dynamics (MDs) simulations. We proposed a computational model of ligand, able to reproduce some evidence from nuclear magnetic resonance (NMR) data, quantitative time resolved fluorometry and X-ray crystallography. We found that a hydrophobic loop, not in the ac...
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PMID: 18242688
PDF is available here.
PDF is available here.
Abstract
Acyl coenzyme A binding protein (ACBP) has been proposed to transport fatty acyl CoAs intracellularly, facilitating their metabolism. In this study, a new mouse recombinant ACBP was produced by insertion of a histidine (his) tag at the C-terminus to allow efficient purification by Ni-affinity chromat...
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PMID: 18178100
PDF is available here.
PDF is available here.
Biochemical Journal (410)3 2008
Abstract
We microinjected fluorescently labelled liver bovine ACBP (acyl-CoA-binding protein) [FACI-50 (fluorescent acyl-CoA indicator-50)] into HeLa and BMGE (bovine mammary gland epithelial) cell lines to characterize the localization and dynamics of ACBP in living cells. Results showed that ACBP targeted...
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PMID: 17953517
PDF is available here.
PDF is available here.
Abstract
It is demonstrated that single-molecule tracking of a fluorescently labeled protein undergoing transient binding to model membranes presents a useful method of obtaining fluid properties. The labeled ACBP protein was tracked during its binding to free-standing giant unilamellar vesicles (GUVs) and s...
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PMID: 18181653
PDF is available here.
PDF is available here.
Abstract
We investigated the role of human ACBP on transcriptional regulation of the putative HNF-4alpha target gene HMG-CoA synthase 1 (HMGCS1). As shown by promoter-reporter assays ACBP represses the HNF-4alpha-induced activity of a 617bp HMGCS1 promoter fragment by approximately 80% in HepG2 cells as well...
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PMID: 19088433
PDF is available here.
PDF is available here.
Neuroscience (150)2 2007
Abstract
We have examined the effect of i.c.v. administration of synthetic rat ODN, its C-terminal octapeptide (OP) and the head-to-tail cyclic analog cyclo(1-8)OP (cOP) on feeding behavior in the goldfish model. i.c.v. injection of graded doses of ODN (2.5-10 pmol/g body weight (BW)) induced a dose-dependen...
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PMID: 17936516
PDF is available here.
PDF is available here.
Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence (42)6 2007
Abstract
We investigated the relationship between the genetic variants of the diazepam biding inhibitor (DBI) gene polymorphism and alcoholism. We analyzed the DBI genotypes using a polymerase chain reaction with confronting two-pair novel primers (PCR-CTPP) method in 180 healthy controls and 43 alcoholic. T...
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PMID: 18240651
PDF is available here.
PDF is available here.
Abstract
Abstract
Our previous in vivo experiment demonstrates that chronic morphine treatment up-regulates diazepam binding inhibitor (DBI) transcripts in mouse cerebral cortex, although detailed mechanisms were unclear (Katsura et al. [1998] J. Neurochem. 71:2638-2641). This study sought to elucidate the precise me...
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PMID: 17638297
PDF is available here.
PDF is available here.
Abstract
We were able to detect a significant association between a non-synonymous coding variant of DBI with anxiety disorders with panic attacks. The rare allele of this polymorphism was more frequent in controls than in patients (OR=0.43; 95% CI: 0.19-0.95). In conclusion, these results suggest a central...
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PMID: 16904689
PDF is available here.
PDF is available here.
Neuropsychopharmacology (32)7 2007
Abstract
We have previously reported that ODN exerts a potent anorexigenic effect in rat and we have found that the action of ODN is not affected by the mixed CBR/PBR agonist diazepam. In the present report, we have tested the possible involvement of the metabotropic receptor in the anorexigenic activity of...
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PMID: 17151595
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (299)1-2 2007
Abstract
Besides serving as essential substrates for beta-oxidation and synthesis of triacylglycerols and more complex lipids like sphingolipids and sterol esters, long-chain fatty acyl-CoA esters are increasingly being recognized as important regulators of enzyme activities and gene transcription. Acyl-CoA...
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PMID: 17013545
PDF is available here.
PDF is available here.
Abstract
We focus on deciphering the initial step along the photobleaching pathway. Utilizing an array of recently developed single-molecule and ensemble spectroscopies and doubly labeled Acyl-CoA binding protein and double-stranded DNA as model systems, we study these photobleaching pathways, which place fu...
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PMID: 17375921
PDF is available here.
PDF is available here.
Abstract
We created a transgenic mouse line overexpressing DBI gene. Transgenic mice had a 37x increased protein expression and immunohistochemistry showed excessive glial expression in the infragranular region of the dentate gyrus. Transgenic animals had significantly larger lateral ventricles and decreased...
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PMID: 17150371
PDF is available here.
PDF is available here.
Abstract
The acyl-CoA binding protein (ACBP) is essential for the fatty acid metabolism, membrane structure, membrane fusion, and ceramide synthesis. Here high resolution crystal structures of human cytosolic liver ACBP, unliganded and liganded with a physiological ligand, myristoyl-CoA are described. The bi...
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PMID: 17044054
PDF is available here.
PDF is available here.
Abstract
beta-d-Glucosyl-O-l-tyrosine (1) is a humoral factor that stimulates transcription of the acyl-CoA binding protein (ACBP) in the pheromone gland of the Silkmoth, Bombyx mori. This paper describes stereoselective synthesis of five analogs that changed the sugar and/or amino acid part in 1 and their s...
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PMID: 17064908
PDF is available here.
PDF is available here.
Abstract
We show that deletion of Acbp in mouse results in sebocyte hyperplasia and sparse, matted hair with a greasy appearance. Consistent with these gross abnormalities, Acbp is highly expressed in the pilosebaceous units of mouse skin as determined by Northern analysis and in situ hybridization. Loss of...
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PMID: 16902415
PDF is available here.
PDF is available here.
Life Sciences (80)2 2006
Abstract
These results indicate that morphine-induced increase in DBI mRNA expression is mediated via increased Ca(2+) entry through up-regulated L-type HVCCs....
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PMID: 17023003
PDF is available here.
PDF is available here.
Brain Research (1119)1 2006
Abstract
We studied by semiquantitative in situ hybridization the effect of adrenalectomy (ADX) and castration (CX) and short-term replacement therapy on DBI mRNA levels in the male mouse hypothalamus. Cells expressing DBI mRNA were mostly observed in the arcuate nucleus, the median eminence and the ependyma...
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PMID: 16963002
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (281)41 2006
Abstract
We identify acyl-CoA-binding protein (ACBP) as playing a critical role in the activation of calpain upon exposure of mitochondria to both full-length Bid and truncated Bid (t-Bid). Suppression of ACBP levels by small interfering RNA inhibited the t-Bid-induced activation of mitochondrial mu-calpain...
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PMID: 16908521
PDF is available here.
PDF is available here.
Abstract
The X-ray structure of the tetragonal form of apo acyl-CoA-binding protein (ACBP) from the Harderian gland of the South American armadillo Chaetophractus villosus has been solved. ACBP is a carrier for activated long-chain fatty acids and has been associated with many aspects of lipid metabolism. It...
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PMID: 17012783
PDF is available here.
PDF is available here.
Abstract
We present the first report on membrane associated ACBP domain-containing protein-1 (MAA-1), a novel membrane-associated member of the acyl-CoA-binding protein family. We show that in Caenorhabditis elegans, MAA-1 localizes to intracellular membrane organelles in the secretory and endocytic pathway...
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PMID: 16870706
PDF is available here.
PDF is available here.
Microbiology (152)Pt 8 2006
Abstract
In this paper, the identification and functional analysis of a fatty acyl-CoA-binding protein (ACBP) gene from the opportunistic protist Cryptosporidium parvum are described. The CpACBP1 gene encodes a protein of 268 aa that is three times larger than typical ACBPs (i.e. approximately 90 aa) of huma...
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PMID: 16849800
PDF is available here.
PDF is available here.
Abstract
We show that PACAP dose dependently increases DBI gene expression and stimulates endozepine release through activation of PAC1-R. PACAP increases cAMP formation, enhances polyphosphoinositide turnover, and evokes calcium mobilization from intracellular Ca2+ pools. The effect of PACAP on endozepine r...
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PMID: 16888201
PDF is available here.
PDF is available here.
Abstract
The octadecaneuropeptide ODN (QATVGDVNTDRPGLLDLK), a biologically active fragment of diazepam-binding inhibitor, exerts a number of behavioral and neurophysiological activities. The presence of a proline residue in the sequence of ODN led us to investigate the role of proline endopeptidase (PEP) in...
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PMID: 16406204
PDF is available here.
PDF is available here.
Abstract
These results illustrate the power of combining stopped-flow kinetics and NMR spectroscopy to analyze protein folding....
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PMID: 16641108
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (284)1-2 2006
Abstract
We show here that the relatively high basal promoter activity of the rat ACBP gene in fibroblasts and hepatoma cells relies on sequences between -331 to -182 and on the Sp1 and NF-Y sites at -172 and -143, respectively. The basal transcription is modulated by members of the PPAR and SREBP families....
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PMID: 16411019
PDF is available here.
PDF is available here.
Abstract
There were no changes in fasting CCK plasma levels or DBI expression. This may suggest that they do not play a major role as risk factors for alcohol-induced pancreatitis....
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PMID: 17101560
PDF is available here.
PDF is available here.
Bioconjugate Chemistry (17)5 2006
Abstract
Synthesis of a new fluorescent rhodamine derivative, dye 1, is reported. This probe is different from other rhodamines insofar as it has several (four) carboxylic acid functionalities to promote water solubility and facilitate conjugation to proteins. It also has an aryl bromide functionality that c...
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PMID: 16984131
PDF is available here.
PDF is available here.
Abstract
A cDNA encoding an acyl-CoA binding protein (ACBP) homologue has been cloned from a cDNA library made from mRNA isolated from epidermis of young leaves of Agave americana L. The derived amino acid sequence reveals a protein corresponding to the membrane-associated form of ACBPs only previously descr...
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PMID: 16531053
PDF is available here.
PDF is available here.
Computational systems bioinformatics / Life Sciences Society. Computational Systems Bioinformatics Conference () 2006
Abstract
We present a data-driven algorithm capable of computing a set of structures (ensemble) directly from sparse experimental restraints. For both denatured and disordered proteins, we formulate the structure determination problem as the computation of an ensemble of structures from the restraints. In th...
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PMID: 17369626
PDF is available here.
PDF is available here.
Abstract
Stupor is a condition from which the subject can be aroused only by vigorous stimuli. Most patients with stupor have a diffuse organic cerebral dysfunction. Rarely stupor is recurrent and no specific causes can be found. Patients with idiopathic recurrent stupor were awakened by i.v. administration...
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PMID: 16233983
PDF is available here.
PDF is available here.
Abstract
We study protein and nucleic acid structure and dynamics using single-molecule FRET and alternating-laser excitation. Freely diffusing molecules are sorted into subpopulations based on single-molecule signals detected within 100 micros to 1 ms. Distance distributions caused by fluctuations faster th...
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PMID: 16287971
PDF is available here.
PDF is available here.
Molecular Brain Research (141)2 2005
Abstract
We studied the effects of the acute intracerebroventricular administration of ODN (2 microg/rat) and the ODN antagonist to metabotropic receptor, cyclo(1-8)[Dleu5]OP (20 microg/rat), on the gene expression of the two neuropeptides in castrated male rat. ODN administration resulted in a 45% increase...
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PMID: 16154662
PDF is available here.
PDF is available here.
Abstract
We reproduced the previously published observations showing inhibition of HSL activity by LC-CoA in adipocytes. The inhibitory effect of LC-CoA on adipocyte HSL was dependent on phosphorylation and enhanced by acyl-CoA-binding protein (ACBP). In contrast, the stimulatory effect on islet lipase activ...
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PMID: 16091387
PDF is available here.
PDF is available here.
Abstract
We identified new transcripts in human and mouse tissues, that had been generated by alternative first exon usage. Quantitative RT-PCR analyses showed a high expression of the new human transcript, ACBP-1c, in adipose tissue. By promoter reporter gene assays, specific regulation of this transcript b...
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PMID: 16055366
PDF is available here.
PDF is available here.
Abstract
We have investigated the effect of somatostatin on DBI mRNA level and endozepine secretion in rat astrocytes in secondary culture. Somatostatin reduced in a concentration-dependent manner the level of DBI mRNA in cultured astrocytes. This inhibitory effect was mimicked by the selective sst4 receptor...
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PMID: 16033415
PDF is available here.
PDF is available here.
Abstract
We examined the effects of Abeta on biosynthesis and release of diazepam-binding inhibitor (DBI), a polypeptide primarily expressed by astroglial cells in the CNS. Quantitative RT-PCR and specific radioimmunoassay demonstrated that aggregated Abeta(25-35), at concentrations up to 10(-4) m, induced a...
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PMID: 16033417
PDF is available here.
PDF is available here.
Biochemistry (Washington) (44)30 2005
Abstract
Although studies in vitro and in yeast suggest that acyl-CoA binding protein ACBP may modulate long-chain fatty acyl-CoA (LCFA-CoA) distribution, its physiological function in mammals is unresolved. To address this issue, the effect of ACBP on liver LCFA-CoA pool size, acyl chain com...
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PMID: 16042405
PDF is available here.
PDF is available here.
Abstract
Molecular Brain Research (137)1-2 2005
Abstract
We examined the correlation between opiate dependence and the mRNA expression of DBI. We found that chronic morphine treatment enabled CPP and increased the DBI mRNA expression in crucial brain regions of addiction. Withdrawal for 3 days caused significant physical signs and further increased the DB...
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PMID: 15950760
PDF is available here.
PDF is available here.
Trends in Cell Biology (15)6 2005
Abstract
We summarize progress in the identification and characterization of the enzymes, the transport of ceramide from the endoplasmic reticulum to the Golgi apparatus, and discuss how regulating the synthesis of sphingolipids might impact upon their functions....
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PMID: 15953549
PDF is available here.
PDF is available here.
Abstract
We cloned the cDNA from Helicoverpa armigera (Har) utilizing rapid amplification of cDNA ends (RACE). By homology search, Har-DBI/ACBP is conserved with the DBI/ACBPs known from other insects. Northern blot analysis showed that DBI/ACBP gene expressed in nonneural and neural tissues. RT-PCR combined...
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PMID: 15993651
PDF is available here.
PDF is available here.
Abstract
Although long-chain fatty acyl-coenzyme A (LCFA-CoA) thioesters are specific high-affinity ligands for hepatocyte nuclear factor-4alpha (HNF-4alpha) and peroxisome proliferator-activated receptor-alpha (PPARalpha), X-ray crystals of the respective purified recombinant ligand-binding domains (LBD) do...
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PMID: 16149734
PDF is available here.
PDF is available here.
Abstract
We found that the peptide signal spore differentiation factor 2 (SDF-2) is processed from acyl-CoA binding protein, AcbA. The mammalian homolog of AcbA is processed to diazepam binding inhibitor that binds to the GABA(A) receptor in the brain and to peripheral 1,4 benzodiazepine receptors. Although...
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PMID: 15897458
PDF is available here.
PDF is available here.
Journal of Molecular Biology (347)5 2005
Abstract
We also provided new insights into the mechanism of formation of the native state of this protein....
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PMID: 15784263
PDF is available here.
PDF is available here.
Abstract
We discuss how chronic nicotine exposure to neurons affects expression of diazepam binding inhibitor (DBI), an endogenous anxiogenic neuropeptide supposed to be a common substance participating drug dependence, and function of L-type high voltage-gated Ca(2+) channels (HVCCs). We also discuss the fu...
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PMID: 15764844
PDF is available here.
PDF is available here.
Abstract
We confirm a previous observation that ACBP expression in rodent liver is down-regulated by fasting, and we show that insulin but not glucose is the inducer of ACBP expression in primary rat hepatocytes. In keeping with the regulation by insulin, we show that ACBP is a sterol regulatory element-bind...
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PMID: 15611101
PDF is available here.
PDF is available here.