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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Interleukins (18):
Recent article
Interleukins
Missouri medicine (108)4 2011
Abstract
We now are at the cusp of yet another such overhaul with the protease inhibitors about to be introduced into the market....
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PMID: 21905441
PDF is available here.
PDF is available here.
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Abstract
We also studied progression of fibrosis in relation to rs12979860 C/T genotypes over two years.
82% of the patients were on HAART (74% without detectable HI viremia) and 67% were haemophiliacs, respectively. HCV genotype 1 was present in 62%. Cross-sectional median liver stiffness wa...
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PMID: 21813376
PDF is available here.
PDF is available here.
Abstract
We assessed hepatovenous pressure gradient (HVPG), liver stiffness (transient elastography), and interleukin (IL)-28B polymorphisms (rs12979860) in 90 cirrhotic patients with HCV infection (82% genotype 1 or 4) before antiviral therapy with pegylated interferon and ribavirin. Efficacy and safety wer...
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PMID: 21397726
PDF is available here.
PDF is available here.
PLoS Pathogens (7)6 2011
Abstract
Our results indicate that SLPs isolated from C. difficile can activate innate and adaptive immunity and that these effects are mediated by TLR4, with TLR4 having a functional role in experimental C. difficile infection. This suggests an important role for SLPs in the recognition of C. difficile by t...
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PMID: 21738466
PDF is available here.
PDF is available here.
Nature Immunology (12)5 2011
Abstract
We will discuss how the expression of IL-22 and IL-22R is regulated, the functions of the IL-22-IL-22R pathway in regulating immunity, inflammation and tissue homeostasis, and the therapeutic potential of targeting this pathway in human disease....
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PMID: 21502992
PDF is available here.
PDF is available here.
Nature Immunology (12)4 2011
Abstract
We show that in contrast to T(H)17 cells, both types of RORγt+ ILCs constitutively produced most of the intestinal IL-22 and that the symbiotic microbiota repressed this function through epithelial expression of IL-25. This function was greater in the absence of adaptive immunity and was fully rest...
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PMID: 21336274
PDF is available here.
PDF is available here.
Abstract
We found strong evidence of association with two variants in the IL2/IL21 (rs6822844, genotypic P = 3·3 × 10(-4) ; rs2069778, genotypic P = 7·86 × 10(-4)) region.
The findings, although requiring replication, suggest that IL2/IL21 may play a key role in the pathogenesis of psoria...
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PMID: 21375519
PDF is available here.
PDF is available here.
Abstract
Naïve T cells are multipotential precursors that differentiate into various effector subsets, such as T helper type 1 (Th1) and Th2 cells, which are characterized by their distinct functions. The IL-17-producing T helper (Th17) cell has been recently identified as a new subset of th...
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PMID: 21035432
PDF is available here.
PDF is available here.
Abstract
To identify the best combination of serum cytokines and clinical parameters to diagnose rapidly early-onset neonatal infection (EONI) in critically ill preterm infants. At birth, most critically ill neonates are receiving broad-spectrum antibiotics pending bacterial culture results,...
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PMID: 20495505
PDF is available here.
PDF is available here.
Abstract
We sought to outline many of the recent advances in uncovering the cell and molecular mechanisms that generate Th2 responses.
It is clear that the Th2 pathway can no longer be considered a 'default pathway' of the lung immune system as multiple cells and cytokines have now been ident...
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PMID: 21150435
PDF is available here.
PDF is available here.
Abstract
We developed a tumour cell vaccine expressing a glycosylphosphatidylinositol (GPI)-anchored IL-21 to test the effect of immunotherapy of melanoma in mouse model. The results indicated that the tumour vaccine was functional, exhibiting delayed tumour growth and prolonging longevity of tumour bearing...
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PMID: 20727044
PDF is available here.
PDF is available here.
Abstract
There is evidence from both epidemiology and laboratory studies that perfluorinated compounds may be immunotoxic, affecting both cell-mediated and humoral immunity. The overall goal of this study was to investigate the mechanisms underlying the immunotoxic effects of perfluorooctane sulfonate (PFOS)...
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PMID: 21075133
PDF is available here.
PDF is available here.
Journal of Internal Medicine (269)1 2011
Abstract
Abstract
We analyzed the steroid sensitivity of ovalbumin (OVA) reactive helper T (Th) cell clones both in vitro and in vivo.
For in vitro experiments, Th clones were cultured with antigen-presenting cells, OVA, and various concentrations of dexamethasone (DEX). The proliferative response of...
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PMID: 21646805
PDF is available here.
PDF is available here.
Abstract
Unbalanced Th1/Th2 T-cell responses in the liver are a characteristic of hepatic inflammation and subsequent liver fibrosis. The recently discovered Th17 cells, a subtype of CD4(+) T-helper cells mainly producing IL-17 and IL-22, have initially been linked to host defense against inf...
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PMID: 21197451
PDF is available here.
PDF is available here.
Abstract
We generated a transgenic mouse model with overexpression of IL-22 specifically in adipose tissue. The IL-22 transgenic mice had no apparent changes in obesity and insulin resistance after feeding with high fat diet (HFD). Unexpectedly, all the IL-22 transgenic mice fed with HFD for four months deve...
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PMID: 21897855
PDF is available here.
PDF is available here.
Abstract
We found that IL-22 suppressed the growth of A498 cells in a dose-dependent manner and inhibited the growth of A498 xenografts. We also observed that IL-22 produced a dose-dependent inhibitory effect on A498 cells that involved the induction of G2/M cell cycle arrest without cell apoptosis. Moreover...
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PMID: 21625390
PDF is available here.
PDF is available here.
Abstract
We therefore analyzed the expression of these TNF cytokines in AE, seborrheic eczema (SE) and healthy controls (HC). The serum/plasma concentration of BAFF, APRIL and a close TNF member TWEAK (TNF-like weak inducer of apoptosis) was measured by ELISA. The expression of these cytokines and their rece...
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PMID: 21765951
PDF is available here.
PDF is available here.
Abstract
We performed ex vivo experiments to evaluate the stimulation of cytokine secretion by carbamazepine, carbamazepine-10,11-epoxide, iminostilbene and acridine. IL-5, IL-6 and IL-10 were quantified as markers of the Th2 pathway, and IL-2 and IFN-γ were used as markers of the Th1 pathway. Blood samples...
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PMID: 21441615
PDF is available here.
PDF is available here.
Abstract
We asked how the IFN-induced desensitization integrates into the network built by the multiple type I IFN subtypes and type III IFNs. We show that priming of cells with either type I IFN or type III IFN interferes with the cell's ability to further respond to all IFN α subtypes. Importantly, primed...
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PMID: 21779393
PDF is available here.
PDF is available here.
Annals of Hepatology (10)4 2011
Abstract
We studied 102 patients, 60% were men, and 40% of them were rs8099917 TT and 18% rs12979860 CC. Mean baseline serum HCV RNA was 1.673.092 IU/mL and mean F score was: 2.10 ± 1.18 (21% cirrhotic). SVR rate was higher in rs8099917 TT genotypes (55%) when compared to GT/GG (25%) (p = 0.002) and in rs15...
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PMID: 21911885
PDF is available here.
PDF is available here.
Abstract
Experimental autoimmune uveoretinitis (EAU) serves as a model for human intraocular inflammation. IFN-β has been used in the treatment of certain autoimmune diseases. Earlier studies showed that it ameliorated EAU; however, the mechanisms involved in this inhibition are still largel...
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PMID: 21573074
PDF is available here.
PDF is available here.
Abstract
We confirmed significant down-regulation of a number of genes that have been well characterized as progesterone sensitive (IL-1B, IL-6, PTGS2, and GJA1). However, the top and sixth most down-regulated transcripts encoded two cytokines, IL-11 and IL-24, respectively, not previously implicated in medi...
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PMID: 20843944
PDF is available here.
PDF is available here.
Nature Immunology (11)12 2010
Abstract
We show that IL-27p28, independently of EBI3, antagonized cytokine signaling through gp130 and IL-6-mediated production of IL-17 and IL-10. Similarly, the ability to generate antibody responses was dependent on the activity of gp130-signaling cytokines. Mice transgenic for expression of IL-27p28 sho...
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PMID: 21057510
PDF is available here.
PDF is available here.
Nature Immunology (11)12 2010
Abstract
We show that polyclonal T cells responded at higher rates to cells expressing CD1a than to those expressing CD1b, CD1c or CD1d. Unlike the repertoire of invariant natural killer T (NKT) cells, the CD1a-autoreactive repertoire contained diverse T cell antigen receptors (TCRs). Functionally, many CD1a...
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PMID: 21037579
PDF is available here.
PDF is available here.
Abstract
We investigated the role of IL-32 in the inflammatory activation of cultured rat primary astrocytes. Treatment of IL-32 increased ROS production and augmented lipopolysaccharide-induced increased production of nitric oxide as well as the expression of iNOS. IL-32 also induced the expression of MMP-9...
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PMID: 20888796
PDF is available here.
PDF is available here.
Abstract
BACKGROUND: Endogenous uveitis is a sight-threatening disease. In addition to corticosteroids, immunosuppressive agents are commonly used to treat patients with severe course. Immunosuppressive drugs act nonspecifically, rather than providing a specific interaction with the critical pathogenetic pat...
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PMID: 20737162
PDF is available here.
PDF is available here.
Abstract
We tested the hypothesis that patients who receive combined propofol/paravertebral anesthesia-analgesia (propofol/paravertebral) exhibited reduced levels of protumorigenic cytokines and matrix metalloproteinases (MMPs) and elevated levels of antitumorigenic cytokines compared with patients receiving...
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PMID: 20975461
PDF is available here.
PDF is available here.
Abstract
We showed that loxoribine up-regulated the expression of TLR7, CD40, CD54, CD80, CD83 and CCR7 and stimulated the production of IL-12, IL-23, IL-27 and IL-10 by MoDCs, whereas the level of interferon (IFN)-β was not modulated. Allogeneic CD4(+)T cells in co-culture with loxoribine-treated MoDCs pro...
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PMID: 20817120
PDF is available here.
PDF is available here.
Abstract
We show that T(H)17 differentiation can occur in the absence of TGF-β signalling. Neither IL-6 nor IL-23 alone efficiently generated T(H)17 cells; however, these cytokines in combination with IL-1β effectively induced IL-17 production in naive precursors, independently of TGF-β. Epigenetic modifi...
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PMID: 20962846
PDF is available here.
PDF is available here.
Abstract
We found that IL-1, but not IL-33, played a substantial role in induction of T cell-mediated type IV hypersensitivity such as contact and delayed-type hypersensitivity and autoimmune diseases such as experimental autoimmune encephalomyelitis. Most notably, however, IL-33 was important for innate-typ...
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PMID: 20937871
PDF is available here.
PDF is available here.
British Journal of Cancer (103)9 2010
Abstract
We estimated odds ratios (ORs) and 95% confidence intervals (CIs) to investigate the association between serum concentrations of interleukin (IL) β, 2, 8, 10, 12p70, granulocyte macrophage colony stimulating factor, interferon-γ, and tumour necrosis factor-α, measured over time, flavonol intake,...
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PMID: 20924374
PDF is available here.
PDF is available here.
Abstract
To explore the mechanism of electroacupuncture on rheumatoid arthritis (RA).
In a randomized and controlled trial, sixty-three cases with RA were randomly divided into an electroacupuncture group (n = 32) and a simple acupuncture group (n = 31). Baihui (GV 20), Fengchi (GB 20), Quchi (LI 11), Waigua...
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PMID: 21058483
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of glabridin on dendritic cells, which play an essential role in innate and adaptive immune responses. Glabridin inhibited lipopolysaccharide-, poly (I:C)-, or zymosan-induced phenotypic maturation of dendritic cells (DCs), as proven by the decreased expression of CD40, CD...
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PMID: 20633530
PDF is available here.
PDF is available here.
Abstract
The immunomodulatory activity of a synbiotic combination containing three bacterial strains (Lactobacillus helveticus R0052, Bifidobacterium longum subsp. infantis R0033 and Bifidobacterium bifidum R0071) and short-chain fructooligosaccharide was examined in two distinct infectious r...
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PMID: 20929951
PDF is available here.
PDF is available here.
Journal of Surgical Research (163)2 2010
Abstract
The concentration of IL-33 and soluble ST2 was significantly higher in ALF, ACLF, and CHF patients compared with the controls. Soluble ST2 serum concentration was significantly elevated in ALF and ACLF compared with CHF; moreover, soluble ST2 was significantly higher in CHF compared with healthy con...
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PMID: 20638676
PDF is available here.
PDF is available here.
Journal of Immunology (185)6 2010
Abstract
We report that IL-33 directly stimulates eosinophil differentiation from CD117(+) progenitors in an IL-5-dependent manner. Although resting eosinophils expressed moderate levels of the IL-33R alpha-chain (ST2L), eosinophils that accumulated in the airways of mice with OVA-induced asthma expressed in...
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PMID: 20693421
PDF is available here.
PDF is available here.
Abstract
Anti-Cancer Drugs (21)8 2010
Abstract
I clinical trial data has shown that a recombinant adenovirus expressing MDA-7/IL-24 [Ad.mda-7 (INGN-241)] was safe and had measurable tumoricidal effects in over 40% of patients, which strongly argues that MDA-7/IL-24 may have significant therapeutic value. This review describes what is known about...
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PMID: 20613485
PDF is available here.
PDF is available here.
Abstract
We previously showed that immunotherapy (IT) with IL-21-transduced neuroblastoma cells (Neuro2a/IL-21) cured 33% of syngeneic mice bearing systemic NB. Here, we studied whether the removal of Treg cells could potentiate the therapeutic efficacy of Neuro2a/IL-21 vaccine. The administration of anti-CD...
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PMID: 20039320
PDF is available here.
PDF is available here.
Immunotherapy (2)5 2010
Abstract
We briefly review the key features of these members of the IL-12 cytokine family and discuss their potential relevance to melanoma immunity and antimelanoma immunotherapy....
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PMID: 20874653
PDF is available here.
PDF is available here.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences (35)9 2010
Abstract
To explore the role of IL-21 in the pathogenesis of myasthenia gravis (MG) and its influence on the the class switch of anti-AChR antibodies.
Blood was taken from 26 patients and 18 healthy controls, and the expression of IL-21R mRNA in peripheral blood mononuclear ce...
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PMID: 20871161
PDF is available here.
PDF is available here.
Nature Immunology (11)9 2010
Abstract
We show that the ligand-activated transcription factor aryl hydrocarbon receptor (AhR), which was induced by IL-27, acted in synergy with c-Maf to promote the development of Tr1 cells. After T cell activation under Tr1-skewing conditions, the AhR bound to c-Maf and promoted transactivation of the Il...
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PMID: 20676095
PDF is available here.
PDF is available here.
Abstract
Our findings suggest that PHVHF is a feasible adjuvant modality in the treatment of patients with severe sepsis. With the application of PHVHF treatment, plasma cytokines are effectively removed. Considering the lower cost and better feasibility than continuous high-volume hemofiltration (CHVF), PHV...
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PMID: 20872345
PDF is available here.
PDF is available here.
Abstract
We have demonstrated previously that sialic acid residues of CD44 negatively regulates its receptor function and CD44 plays an important role in the accumulation of T helper type 2 (Th2) cells in the airway of a murine model of acute asthma. Here we evaluated the role of sialidase in the hyaluronic...
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PMID: 20491786
PDF is available here.
PDF is available here.
Abstract
We investigated the transcriptional responses of human extravillous trophoblasts (HTR-8) to infection with P. gingivalis. Over 2000 genes were differentially regulated in HTR-8 cells by P. gingivalis. In ontology analyses of regulated genes, overpopulated biological pathways included mitogen-activat...
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PMID: 20618699
PDF is available here.
PDF is available here.
Abstract
Psoriasis and psoriatic arthritis (PsA) are interrelated heritable diseases. Polymorphisms in the genes encoded in the major histocompatibility complex region have consistently been associated with psoriasis and PsA and account for about 30% of the genetic risk. Recently, the results...
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PMID: 20480402
PDF is available here.
PDF is available here.
Respirology (15)5 2010
Abstract
We explored relationships between obesity and allergic asthma in children.
Twenty-one allergic asthmatics (AA) and 10 non-allergic healthy controls, aged 6-17.9 years were studied. AA group included children with a positive mannitol challenge test, >25 ppb of exhaled nitric oxide and a positive skin...
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PMID: 20456670
PDF is available here.
PDF is available here.
Clinical Immunology (136)1 2010
Abstract
We observed that females receiving unfractionated DBA splenocytes (CD8 intact --> F1) exhibited greater clinical and histological severities of renal disease at 13 weeks compared to males. Surprisingly, sex-based differences in renal disease severity were lost in CD8 depleted --> F1 mice due to an i...
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PMID: 20451460
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
We have found different rates of viral genotype infection depending on the IL28B variant as well as an association of this locus with natural and treatment-mediated response....
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PMID: 20578254
PDF is available here.
PDF is available here.
Gastroenterology (139)1 2010
Abstract
In treatment-naive HCV-1 patients treated with pegylated interferon and ribavirin, a polymorphism upstream of IL-28B is associated with increased on-treatment and sustained virologic response and effectively predicts treatment outcome.
Copyright 2010 AGA Institute. Published by Elsevier Inc. All rig...
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PMID: 20399780
PDF is available here.
PDF is available here.
Abstract
We reported that IL-21 induces granzyme B (GzmB) and GzmB-dependent apoptosis in malignant CD5(+) B cells from patients with chronic lymphocytic leukemia. Several autoimmune diseases (AD) are associated with enhanced frequencies of CD5(+) B cells. Since AD are also associated with elevated IL-21 and...
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PMID: 20394077
PDF is available here.
PDF is available here.
Abstract
We investigated production of Th17-associated cytokines IL-17 and IL-22 in a recall response to Francisella tularensis. Peripheral blood mononuclear cells (PBMCs) from volunteers previously immunized with the F. tularensis live vaccine strain (LVS) were stimulated in vitro with bacterial lysates of...
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PMID: 20626289
PDF is available here.
PDF is available here.
NeuroImage (51)3 2010
Abstract
We investigated IL-6 associations with age in T1-weighted segments and microstructural diffusion indices using MRI in aged rhesus monkeys (Macaca mulatta). Further, we determined if long-term 30% calorie restriction (CR) reduced IL-6 and attenuated its association with lower tissue volume and densit...
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PMID: 20298794
PDF is available here.
PDF is available here.
Abstract
Abstract
ST2 has been proposed to be a regulator of inflammation and Th1/Th2 balance. ST2L is the IL-33 membrane receptor and belongs to the IL-1R family. The soluble variant, ST2s, is identical to the extracellular region of ST2L and competes for IL-33 binding, inhibiting receptor signaling....
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PMID: 20014018
PDF is available here.
PDF is available here.
Mucosal Immunology (3)4 2010
Abstract
We provide evidence that IL-22, which is also produced by Th17 cells, has a critical, first-line defense in candidiasis by controlling the growth of infecting yeasts as well as by contributing to the host's epithelial integrity in the absence of acquired Th1-type immunity. The two pathways are recip...
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PMID: 20445503
PDF is available here.
PDF is available here.
Abstract
T helper 17 (Th17) cells are a newly identified subset of T helper cells that play important roles in host defense against extracellular bacteria as well as in the pathogenesis of autoimmune disease. The functions of Th17 cells are mediated via the production of several cytokines inc...
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PMID: 20305686
PDF is available here.
PDF is available here.
Molecular Therapy (18)7 2010
Abstract
We hypothesized that fusing granulocyte-macrophage colony-stimulation factor (GMCSF) and interleukin (IL)-21 as a single bifunctional cytokine (hereafter GIFT-21) would lead to synergistic anticancer immune effects because of their respective roles in mediating inflammation. Mechanistic analysis of...
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PMID: 20389285
PDF is available here.
PDF is available here.
Abstract
We demonstrate that the IL-1 receptor IL-1R1 was selectively expressed by a subpopulation of iNK cells that localized proximal to IL-1beta-producing conventional dendritic cells (cDCs) within SLT. IL-1R1(hi) iNK cells required continuous exposure to IL-1beta to retain AHR and IL-22 expression, and t...
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PMID: 20620944
PDF is available here.
PDF is available here.