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Intercellular Signaling Peptides and Proteins (24):
- Transforming Growth Factors
- Endothelins
- Wnt Proteins
- Semaphorins
- Interferons
- Epidermal Growth Factor
- Ephrins
- Agouti-Related Protein
- Nerve Growth Factors
- Endothelial Growth Factors
- Parathyroid Hormone-Related Protein
- Hedgehog Proteins
- Angiogenic Proteins
- Tumor Necrosis Factors
- Fibroblast Growth Factors
- TGF-beta Superfamily Proteins
- Tolloid-Like Metalloproteinases
- Platelet-Derived Growth Factor
- Somatomedins
- Kinins
- CCN Intercellular Signaling Proteins
- Cytokines
- Agouti Signaling Protein
- Adipokines
Recent article
Intercellular Signaling Peptides and Proteins
Abstract
We analyzed the ability of each management strategy to control anemia and neutropenia and the percentage of subjects who achieved a successful treatment outcome according to the different management strategies.
During treatment, 43 subjects developed anemia (human erythropoietin, n =...
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PMID: 21876446
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Journal of Neuroscience (31)37 2011
Abstract
We found that many Wnt-signaling genes were dynamically regulated, with an immediate decrease, followed by an eventual normalization during memory consolidation. This rapid decrease in Wnt mRNA was confirmed with individual quantitative PCR and in situ hybridization. We then manipulated Wnt signalin...
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PMID: 21917789
PDF is available here.
PDF is available here.
Circulation (124)11 Suppl 2011
Abstract
We investigated the effect of epidermal growth factor-like domain 7 (Egfl7) on nuclear factor-κB activation, intercellular adhesion molecule-1 expression, and neutrophil adhesion to human coronary artery endothelial cells after calcineurin-inhibition-induced injury.
Human coronary e...
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PMID: 21911813
PDF is available here.
PDF is available here.
Abstract
We will be focusing on ESCs as a promising cell source for cartilage regeneration, the various strategies and approaches employed in chondrogenic differentiation and tissue engineering, the associated outcomes from animal studies, and the challenges that need to be overcome before clinical applicati...
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PMID: 21188652
PDF is available here.
PDF is available here.
Abstract
We use Drosophila to explore the as yet unknown mechanisms regulating this privileged tissue growth. As in mammals, we observe in Drosophila that the CNS is more highly spared than other tissues during nutrient restriction (NR). We demonstrate that anaplastic lymphoma kinase (Alk) efficiently protec...
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PMID: 21816278
PDF is available here.
PDF is available here.
Autoimmunity Reviews (10)10 2011
Abstract
Systemic sclerosis is an autoimmune connective tissue disorder characterized by a widespread microangiopathy, autoimmunity and fibrosis of the skin and of various internal organs. Microangiopathy is characterized by a reduced capillary density and an irregular chaotic architecture th...
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PMID: 21549861
PDF is available here.
PDF is available here.
Orvosi Hetilap (152)29 2011
Abstract
Diabetes mellitus contributes to a number of disorders that can affect the quality of life. Amongst this diabetic foot syndrome and diabetic foot ulceration are serious secondary complications of diabetes mellitus. Persons with diabetic foot ulceration have an increased risk of amputation. In the fir...
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PMID: 21712183
PDF is available here.
PDF is available here.
Abstract
Abstract
We selected gelatin as ECM (extracellular matrix) to support differentiation of mES (mouse embryonic stem) cells into TE (trophectoderm), as gelatin was less expensive and widely used. We found that 0.2% and 1.5% gelatin were the suitable concentrations to induce TE differentiation by means of detec...
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PMID: 21091439
PDF is available here.
PDF is available here.
Abstract
We report the demonstration of a multilayered particle-based delivery system for inducing bone formation in vivo. This new strategy is an alternative approach for in vivo bone formation....
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PMID: 21830494
PDF is available here.
PDF is available here.
Abstract
The primary progressive aphasias (PPA) are a group of clinically, genetically and pathologically heterogeneous neurodegenerative disorders caused by FTLD-tau, FTLD-TDP or Alzheimer's disease pathology. Clinically, three subtypes are recognized, the semantic, logopenic and nonfluent v...
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PMID: 21222598
PDF is available here.
PDF is available here.
Journal of Immunotherapy (34)4 2011
Abstract
As quercetin, which can inhibit phosphatidylinositol 3-kinase, nuclear factor-kappa B, and protein kinase C (PKC) pathways, induced expression of natural killer group 2, member D (NKG2D) ligands on cancer cells and made the cells sensitive to NK -cell-mediated killing; inhibition of...
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PMID: 21499124
PDF is available here.
PDF is available here.
Integrative Biology (3)4 2011
Abstract
We have performed gene co-expression network analysis in three independent microarray datasets and identified two microenvironment networks in human breast cancer tissues. Network I represents crosstalk and cooperation of ECM microenvironment and soluble factors during breast malignancy. The correla...
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PMID: 21165486
PDF is available here.
PDF is available here.
Abstract
Extracellular matrix (ECM)-based scaffold materials have been used successfully in both preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. Results of numerous studies have shown that ECM scaffolds are capable of supporting the g...
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PMID: 21043998
PDF is available here.
PDF is available here.
Abstract
We quantified Dpp concentration and signaling levels during wing disc growth. Both Dpp concentration and signaling gradients scale with tissue size during development. On average, cells divide when Dpp signaling levels have increased by 50%. Our observations are consistent with a growth control mech...
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PMID: 21385708
PDF is available here.
PDF is available here.
Cancer Cell (19)2 2011
Abstract
We report that the Notch ligand Jagged1 is a clinically and functionally important mediator of bone metastasis by activating the Notch pathway in bone cells. Jagged1 promotes tumor growth by stimulating IL-6 release from osteoblasts and directly activates osteoclast differentiation. Furthermore, Jag...
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PMID: 21295524
PDF is available here.
PDF is available here.
Cancer Cell (19)2 2011
Abstract
We report that the Notch ligand Jagged1 is a clinically and functionally important mediator of bone metastasis by activating the Notch pathway in bone cells. Jagged1 promotes tumor growth by stimulating IL-6 release from osteoblasts and directly activates osteoclast differentiation. Furthermore, Jag...
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PMID: 21295524
PDF is available here.
PDF is available here.
Abstract
We investigated how cell density and temporal exposure to chondrogenic factors impacted chondrogenesis of human mesenchymal stem cells (hMSCs) encapsulated in poly(ethylene glycol) diacrylate hydrogels. We found maximal proteoglycan and collagen production in constructs seeded between 10 and 25 ×...
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PMID: 20799905
PDF is available here.
PDF is available here.
Acta Physiologica (201)1 2011
Abstract
We have investigated the effects of apelin peptides on duodenal bicarbonate secretion in vivo and the release of cholecystokinin (CCK) from acutely isolated mucosal cells and the neuroendocrine cell line STC-1.
Lewis × Dark Agouti rats had free access to water and, unless fasted ove...
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PMID: 20726845
PDF is available here.
PDF is available here.
Abstract
We have previously demonstrated that neuroblastoma cells express Dickkopf 1 (Dkk1), an inhibitor of the canonical Wnt pathway which prevents the differentiation of bone-forming cells. Since Dkk1 is a secreted factor, it could have potential clinical application as tumor marker for detecting bone met...
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PMID: 20603237
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)52 2010
Abstract
The mechanism that regulates embryonic liver morphogenesis remains elusive. Progranulin (PGRN) is postulated to play a critical role in regulating pathological liver growth. Nevertheless, the exact regulatory mechanism of PGRN in relation to its functional role in embryonic liver development remains...
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PMID: 20961855
PDF is available here.
PDF is available here.
Abstract
Journal of Trauma (69)6 2010
Abstract
Our aim was to investigate and to clarify the role of HGF and its receptor c-Met in pathogenesis of keloid scars.
This study investigated the expression profile of HGF and c-Met in keloid and normal skin tissue. In addition, the role of normal and keloid keratinocytes in modulating the expression of...
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PMID: 21150524
PDF is available here.
PDF is available here.
Abstract
We investigated PGRN expression in human ALS and in mouse models of motor neuron degeneration. Progranulin plasma or CSF levels in newly diagnosed ALS patients did not differ from those in healthy or disease controls (PGRN mutation-negative FTLD and Alzheimer disease patients). In the mutant SOD1 mo...
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PMID: 21107132
PDF is available here.
PDF is available here.
Abstract
We previously reported impaired transport of topically applied antigen to draining lymph nodes and reduced CHS in the absence of all Langerin(+) skin DC. In this study, we demonstrate that mice with a selective depletion of LC exhibit attenuated CHS only upon sensitization with a low hapten dose but...
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PMID: 20703247
PDF is available here.
PDF is available here.
Abstract
We reported that Tsukushi (TSK), a member of the secreted small leucine rich repeat proteoglycan family, functions as a key coordinator of multiple pathways outside of cells through the regulation of an extracellular signaling network. Here, we show evidence that TSK is critical for the formation of...
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PMID: 21055390
PDF is available here.
PDF is available here.
Abstract
We summarized the currently emerging information regarding the function of SUMOylation in ocular development and pathology....
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PMID: 21091425
PDF is available here.
PDF is available here.
Abstract
We investigated the association between TGFβ and HB-EGF signal transduction via ADAM activation.
The CCK-8 assay in two gastric cancer cell lines was used to determine the effect for cell growth by TGFβ. The effect of two ADAM inhibitors was also evaluated. Induction of EGFR phosphorylation by TGF...
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PMID: 20934403
PDF is available here.
PDF is available here.
Cell Stem Cell (7)5 2010
Abstract
Pluripotent stem cells (PSCs) have been classified into two distinct states: a primitive, naive LIF-dependent state represented by murine ESCs, and a primed bFGF-dependent state observed in murine and rat epiblast stem cells (EpiSCs). The vast similarities between EpiSCs and human ES...
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PMID: 21040897
PDF is available here.
PDF is available here.
Abstract
Diabetes is the leading cause of chronic kidney disease, which in the Thailand is the most common cause of end stage renal disease (ESRD) requiring dialysis. Patients with diabetic kidney disease (DKD) are at a higher risk of mortality, mostly from cardiovascular complications, than...
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PMID: 21280541
PDF is available here.
PDF is available here.
Abstract
Diabetes is the leading cause of chronic kidney disease, which in the Thailand is the most common cause of end stage renal disease (ESRD) requiring dialysis. Patients with diabetic kidney disease (DKD) are at a higher risk of mortality, mostly from cardiovascular complications, than...
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PMID: 21280541
PDF is available here.
PDF is available here.
Abstract
Diabetes is the leading cause of chronic kidney disease, which in the Thailand is the most common cause of end stage renal disease (ESRD) requiring dialysis. Patients with diabetic kidney disease (DKD) are at a higher risk of mortality, mostly from cardiovascular complications, than...
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PMID: 21280541
PDF is available here.
PDF is available here.
Abstract
We integrate high-resolution copy number data with transcriptional profiles and identify the immunoregulatory genes, PD-L1 and PD-L2, as key targets at the 9p24.1 amplification peak in HL and MLBCL cell lines. We extend these findings to laser-capture microdissected primary Hodgkin Reed-Sternberg ce...
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PMID: 20628145
PDF is available here.
PDF is available here.
Clinical calcium (20)11 2010
Abstract
We reported that Notch signaling induces osteogenic differentiation and mineralization of SMC....
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PMID: 21037383
PDF is available here.
PDF is available here.
British Journal of Nutrition (104)9 2010
Abstract
We evaluated the effects of a hexane-ethanol extract of Glycyrrhiza uralensis (HEGU), which lacks glycyrrhizin, on the metastatic characteristics of DU145 prostate cancer cells. HEGU inhibited basal and epidermal growth factor-induced cell migration, invasion and adhesion in a dose-dependent fashion...
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PMID: 20487583
PDF is available here.
PDF is available here.
Abstract
We used pharmacologic, genetic, in vivo, and in vitro experiments to show that activation of the Notch pathway in tubular epithelial cells (TECs) in patients and in mouse models of TIF plays a role in TIF development. Expression of Notch in renal TECs was found to be both necessary and sufficient fo...
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PMID: 20978353
PDF is available here.
PDF is available here.
Cancer Biology & Therapy (10)10 2010
Abstract
Esophageal adenocarcinoma (EAC) arises in the backdrop of reflux-induced metaplastic phenomenon known as Barrett esophagus. The prognosis of advanced EAC is dismal, and there is an urgent need for identifying molecular targets for therapy. Serial Analysis of Gene Expression (SAGE) wa...
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PMID: 20818175
PDF is available here.
PDF is available here.
Abstract
We have applied a novel mitochondria-targeted antioxidant: plastoquinone conjugated with decyltriphenylphosphonium (SkQ1). This antioxidant at nanomolar concentration prevented ROS accumulation and cell death induced by H(2)O(2) in fibroblasts. We found that scavenging of ROS produced by mitochondri...
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PMID: 20446771
PDF is available here.
PDF is available here.
Abstract
We show that mouse mural granulosa cells, which line the follicle wall, express natriuretic peptide precursor type C (Nppc) messenger RNA (mRNA), whereas cumulus cells surrounding oocytes express mRNA of the NPPC receptor NPR2, a guanylyl cyclase. NPPC increased cGMP levels in cumulus cells and oocy...
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PMID: 20947764
PDF is available here.
PDF is available here.
Abstract
Apelin is a recently defined peptide relevant to the mechanism of obesity-related disorders. There has been no report so far about the levels of plasma apelin in obese children.
In this study plasma apelin, adiponectin, and high sensitivity C reactive protein levels were investigated in obese (n=32)...
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PMID: 21158215
PDF is available here.
PDF is available here.
Abstract
We demonstrated that bFGF improves phonation threshold pressure, mucosal wave amplitude, and histologic measures in vocal folds treated after injury. In the present study, we studied the effects of bFGF on gene expression of the extracellular matrix and growth factors in rat vocal fold fibroblasts....
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PMID: 21049855
PDF is available here.
PDF is available here.
Prescrire international (19)109 2010
Abstract
Clinical calcium (20)10 2010
Abstract
Parathyroid hormone (PTH) has clinically appeared as a bone anabolic reagent in Japan. Local or systemic factors produced by various cells are involved in the bone anabolic action of PTH. Insulin-like growth factor-1 and fibroblast growth factor 2 are included in them. Although the significance of c...
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PMID: 20890039
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)3 2010
Abstract
We performed a case-control study with 233 CA patients confirmed by nuclear magnetic resonance angiography and 202 patients who suffered from cardioembolic (non atherogenic) stroke. For all included subjects information on established risk factors was available. Genotyping of 16 selected tagSNPs was...
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PMID: 20664904
PDF is available here.
PDF is available here.
Abstract
The current landscape of growth factors in orthopaedic trauma is dominated by the BMPs, as they are the most extensively studied growth factors in clinical applications pertaining to orthopaedic trauma. Despite this, their application and indications for use in trauma remain controversial. This arti...
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PMID: 20736791
PDF is available here.
PDF is available here.
Journal of Hypertension (28)9 2010
Abstract
We have recently resequenced apelin and AGTRL1 genes to identify candidate polymorphisms in family-based association with hypertension and related phenotypes. In this study, we aimed to determine and replicate these polymorphisms via a larger, independent case-control study in Shanghai Han Chinese....
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PMID: 20485192
PDF is available here.
PDF is available here.
Abstract
To examine the potential use of hemicellulose hydrolysate (HH) for the production of chitosan by Rhizopus oryzae and investigate the influence of contents in HH on mycelia growth and chitosan synthesis.
Compared to xylose medium, HH enhanced mycelia growth, chitosan content and production of R. oryz...
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PMID: 20636326
PDF is available here.
PDF is available here.
Abstract
We highlight exciting new advances and opportunities in studies of cell-cell interactions, mechanical forces, growth factors, and gene expression patterns to improve our understanding of this important process....
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PMID: 21125789
PDF is available here.
PDF is available here.
Abstract
We postulated that CRMP-2 levels affects the actions of LCM on VGSCs. CRMP-2 labeling by LCM analogs was competitively displaced by excess LCM in rat brain lysates. Manipulation of CRMP-2 levels in the neuronal model system CAD cells affected slow inactivation of VGSCs without any effects on other v...
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PMID: 20538611
PDF is available here.
PDF is available here.
Abstract
We find that miR-29a is necessary for human osteoblast differentiation, and miR-29a is increased during differentiation in the mesenchymal precursor cell line hFOB1.19 and in primary cultures of human osteoblasts. Furthermore, the promoter of the expressed sequence tag containing the human miR-29a g...
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PMID: 20551325
PDF is available here.
PDF is available here.
Abstract
We analyzed the phenotypic alterations of human articular chondrocytes in this model on the broad molecular level. Freshly isolated chondrocytes were assembled as micromasses and maintained up to 6 weeks in medium containing human serum. Formation of cartilaginous extracellular matrix (ECM) was eval...
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PMID: 20433912
PDF is available here.
PDF is available here.
Abstract
The results indicated no differences in biomechanical findings among the treatment groups and comparable levels of trabecular bone formation within the fusion site between specimens treated with autogenous bone and those filled with the ultra-concentrated AGF extract. In addition, interbody cage tre...
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PMID: 20672957
PDF is available here.
PDF is available here.
Abstract
We review our current understanding of how Cripto-1 controls stem cell biology and how it integrates with other major embryonic signaling pathways. Because many cancers are thought to derive from a subpopulation of cancer stem-like cells, which may re-express embryonic genes, Cripto-1 signaling may...
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PMID: 20616345
PDF is available here.
PDF is available here.
Abstract
We investigated the adiponectin levels using a number of ELISA assay kits....
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PMID: 20860176
PDF is available here.
PDF is available here.
Abstract
We used a novel technique of freshly isolated and purified human nasal epithelial cells (HNEC) from healthy, nonallergic individuals, which were incubated for 24 h without/with SEB at different concentrations. Chemokine production was evaluated in the supernatant using Cytometric Bead Array. The che...
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PMID: 20132156
PDF is available here.
PDF is available here.
Abstract
We used a novel technique of freshly isolated and purified human nasal epithelial cells (HNEC) from healthy, nonallergic individuals, which were incubated for 24 h without/with SEB at different concentrations. Chemokine production was evaluated in the supernatant using Cytometric Bead Array. The che...
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PMID: 20132156
PDF is available here.
PDF is available here.
Abstract
We used a novel technique of freshly isolated and purified human nasal epithelial cells (HNEC) from healthy, nonallergic individuals, which were incubated for 24 h without/with SEB at different concentrations. Chemokine production was evaluated in the supernatant using Cytometric Bead Array. The che...
|
PMID: 20132156
PDF is available here.
PDF is available here.
Abstract
We used a novel technique of freshly isolated and purified human nasal epithelial cells (HNEC) from healthy, nonallergic individuals, which were incubated for 24 h without/with SEB at different concentrations. Chemokine production was evaluated in the supernatant using Cytometric Bead Array. The che...
|
PMID: 20132156
PDF is available here.
PDF is available here.
Abstract
We used a novel technique of freshly isolated and purified human nasal epithelial cells (HNEC) from healthy, nonallergic individuals, which were incubated for 24 h without/with SEB at different concentrations. Chemokine production was evaluated in the supernatant using Cytometric Bead Array. The che...
|
PMID: 20132156
PDF is available here.
PDF is available here.
Abstract
We used a novel technique of freshly isolated and purified human nasal epithelial cells (HNEC) from healthy, nonallergic individuals, which were incubated for 24 h without/with SEB at different concentrations. Chemokine production was evaluated in the supernatant using Cytometric Bead Array. The che...
|
PMID: 20132156
PDF is available here.
PDF is available here.