Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Myocardial Depressant Factor (0):
Recent article
Myocardial Depressant Factor
Abstract
ICAM-1 contributes to the mechanism of endotoxemic cardiac dysfunction. TNF-alpha is involved in the regulation of myocardial ICAM-1 expression by TLR4....
|
PMID: 17683945
PDF is available here.
PDF is available here.
| < More recent | Older article > |
The Lancet (363)9404 2004
Abstract
We identified 174 significantly upregulated genes in meningococcus-infected blood: six encoded proteins that were of the predicted size and had characteristics of a myocardial depressant factor. Of these, interleukin 6 caused significant myocardial depression in vitro. Removal of interleukin 6 from...
|
PMID: 14738793
PDF is available here.
PDF is available here.
Critical Care Medicine (32)1 2004
Abstract
We found that TAC, a competitive inhibitor of Lzm-S, prevented myocardial depression in experimental sepsis. Only specific NAG structures are inhibitory to Lzm-S's depressant activity. TAC may be useful in attenuating cardiovascular collapse in sepsis....
|
PMID: 14707578
PDF is available here.
PDF is available here.
Critical Care Medicine (30)10 2002
Abstract
Critical Care Medicine (30)10 2002
Abstract
Myocardial depression in meningococcal sepsis is mediated in part by circulating myocardial depressant factors. Myocardial depressant factors are also released when whole blood or peripheral blood mononuclear cells of healthy donors are exposed to heat-killed meningococci. Release of the factors app...
|
PMID: 12394943
PDF is available here.
PDF is available here.
Abstract
These results indicate that gut-derived myocardial depressant factors transported in mesenteric lymph contribute to burn-induced impairment of cardiac contractile function, because burn-induced cardiac dysfunction can be totally abrogated by pre-burn mesenteric lymph duct ligation....
|
PMID: 12353930
PDF is available here.
PDF is available here.
Abstract
Abstract
Negative inotropic substances released from isolated postischemic hearts reduce Ca2+ transient and cell contraction through cAMP-independent and cGMP-independent blockage of L-type Ca2+ channels....
|
PMID: 11216995
PDF is available here.
PDF is available here.
Endocrine Regulations (34)3 2000
Abstract
These data suggest that cardiodepressant factor released together with vasopressin from the posterior pituitary lobe decrease the heart contraction rate and improves coronary circulation affected by vasopressin release....
|
PMID: 11074663
PDF is available here.
PDF is available here.
Abstract
We have demonstrated recently that homogenates derived from the pancreas but not other peritoneal organs activate naive leukocytes. Production of such activating factors can be blocked by a serine protease inhibitor. Thus, factors generated by pancreatic proteases may possibly produce cellular activ...
|
PMID: 10909890
PDF is available here.
PDF is available here.
Abstract
Abstract
In our previous research the presence of a cardiodepressant factor in the medium incubating the posterior pituitary lobe 'in situ' has been demonstrated. This study presents experiments demonstrating cardiodepressant activity in medium incubating the posterior pituitary lobe 'in situ' and in dialysa...
|
PMID: 9223027
PDF is available here.
PDF is available here.
Abstract
ASAIO Journal (42)5 1996
Abstract
I had biphasic responses, the positive inotropism accorded to catecholamines, whereas negative inotropism was equal in each patient (-40.3%). Group II had a biphasic response with negative (-15%) inotropism noted. Group III was weakly biphasic. The data indicate there was myocardial depressive activ...
|
PMID: 8945020
PDF is available here.
PDF is available here.
Pharmacology (49)6 1994
Abstract
Our data are consistent with an involvement of thromboxane A2 in splanchnic artery occlusion shock and suggest that BAY u3405 might be of benefit in low-flow states such as circulatory shock....
|
PMID: 7878075
PDF is available here.
PDF is available here.
Abstract
An extremely severe circulatory shock was produced in two different manners in urethane-anaesthetized rats in order to evaluate the key role of platelet-activating factor (PAF) and myocardial depressant factor (MDF) in low flow states. Haemorrhagic shock was induced by intermittently withdrawing abo...
|
PMID: 8012759
PDF is available here.
PDF is available here.
Critical Care Medicine (21)2 Suppl 1993
Abstract
Intestinal mucosal injury, as seen in critical illness, may induce increased translocation of bacteria and endotoxin and release of myocardial depressant factors into the circulation....
|
PMID: 8428491
PDF is available here.
PDF is available here.
Abstract
Anaesthetized rats, subjected to total occlusion of the superior mesenteric artery and the celiac trunk for 45 min, developed a severe shock state (splanchnic artery occlusion shock) resulting in a fatal outcome within 75-90 min after release of the occlusion. Shocked rats, treated with an intraveno...
|
PMID: 1468489
PDF is available here.
PDF is available here.
Abstract
Our findings suggest that NO production plays an important role in the pathophysiology of hemorrhagic shock....
|
PMID: 1376822
PDF is available here.
PDF is available here.
Circulatory shock (36)2 1992
Abstract
We have examined the effects of adenosine, an adenosine A1-receptor antagonist, and their combination in a rat model of SAO shock. Pentobarbital-anesthetized rats were subjected to a 90-min occlusion of both the celiac and superior mesenteric arteries followed by reperfusion. Rats given only the veh...
|
PMID: 1582007
PDF is available here.
PDF is available here.
American Journal of Physiology -- Legacy Content (261)6 Pt 2 1991
Abstract
Abstract
Previous studies have indicated that there is a cardiodepressant factor in the medium incubating the posterior pituitary lobe in situ. The cardiodepressant activity of the medium incubating the posterior pituitary lobe before and during stimulation of the vagus nerves was tested on isolated auricles...
|
PMID: 1793893
PDF is available here.
PDF is available here.
Abstract
We studied the effects of transforming growth factor-beta (TGF-beta), tissue plasminogen activator (tPA), and their combination in cats subjected to splanchnic artery occlusion (SAO) with reperfusion. Untreated anesthetized cats subjected to total occlusion of the celiac, superior, and inferior mese...
|
PMID: 1719297
PDF is available here.
PDF is available here.
Abstract
Circulatory shock (33)3 1991
Abstract
We have examined the effects of benidipine, a novel long-acting calcium antagonist, in a rat model of SAO shock, focusing on endothelial damage. Pentobarbital-anesthetized rats were subjected to 90-min occlusion of both the celiac and superior mesenteric arteries, followed by reperfusion. Rats given...
|
PMID: 2044207
PDF is available here.
PDF is available here.
Abstract
Hypovolemic hemorrhagic shock was induced in male anesthetized rats by intermittently withdrawing blood from an iliac catheter over a period of 20 min until mean arterial pressure (MAP) fell to 30 mm Hg. Survival rate, MAP, plasma myocardial depressant factor (MDF) activity and plasma levels of both...
|
PMID: 1709231
PDF is available here.
PDF is available here.
Anesthesiology (73)4 1990
Abstract
Depressed left ventricular (LV) contractility in sepsis has been ascribed to the presence of circulating cardiodepressant substance (filterable cardiodepressant factor in sepsis [FCS]); however, this finding is controversial. The authors hypothesized that if a decrease in LV contractility indeed occ...
|
PMID: 2221436
PDF is available here.
PDF is available here.
Abstract
Pentobarbital anesthetized rats subjected to Noble-Collip drum trauma developed a shock state characterized by marked hypotension, increases in plasma cathepsin D (9.6-fold), free amino-nitrogen (4.0-fold), and myocardial depressant factor (5.2-fold) activities, and a survival time of 1.90 +/- 0.23...
|
PMID: 2401310
PDF is available here.
PDF is available here.
Abstract
Abstract
We studied the effects of a new potent thromboxane A2 receptor antagonist as a protective measure in circulatory shock induced by splanchnic artery occlusion and reperfusion. The celiac and superior mesenteric arteries of anesthetized rats were occluded for 40 min followed by reperfusion, resulting...
|
PMID: 2140129
PDF is available here.
PDF is available here.
Abstract
We studied the effects of BN 50739, a novel PAF antagonist, in a rat model of traumatic shock. Pentobarbital anesthetized rats subjected to Noble-Collip drum trauma developed a shock state characterized by marked hypotension, significant increases in plasma cathepsin D (4.2-fold), free amino-nitroge...
|
PMID: 2165204
PDF is available here.
PDF is available here.
Circulatory shock (30)2 1990
Abstract
We investigated the effects of a novel, non-glucocorticoid 21-aminosteroid, U74006F, in the pathogenesis of splanchnic artery occlusion (SAO) shock in rats. Pentobarbital-anesthetized (40 mg/kg) rats were subjected to 40 min of occlusion of both the celiac and superior mesenteric arteries followed b...
|
PMID: 2311204
PDF is available here.
PDF is available here.
Resuscitation (18)2-3 1989
Abstract
These results suggest a beneficial effect of FDP in SAO shock....
|
PMID: 2555881
PDF is available here.
PDF is available here.
Abstract
We studied the acute intravascular effects of some of these unsaturated fatty acids (i.e., eicosapentaenoic acid, EPA; docosahexaenoic acid, DHA) along with omega-6 unsaturated fatty acids, (i.e., linoleic and linolenic acid) in splanchnic artery occlusion (SAO) shock in rats. Anesthetized rats subj...
|
PMID: 2550971
PDF is available here.
PDF is available here.
Journal of Chemotherapy (1)4 Suppl 1989
Abstract
European Journal of Pharmacology (165)2-3 1989
Abstract
The purpose of this study was to examine the effects of a new potent peptidoleukotriene receptor antagonist, SK&F 104353, in splanchnic artery occlusion shock. SK&F 104353 was administered as a 1 mg/kg initial bolus followed by an infusion of 3 mg/kg per h for the entire 2 h post-reperfusion observa...
|
PMID: 2550251
PDF is available here.
PDF is available here.
Abstract
Abstract
Using spontaneously beating rat myocardial cells as an in vitro model of myocardial depression, recent studies demonstrated that septic shock patients' sera frequently contain a myocardial depressant substance (MDS) that is associated with a reversible decrease in left ventricular ejection fraction...
|
PMID: 2707065
PDF is available here.
PDF is available here.
Thrombosis Research (53)3 1989
Abstract
We have investigated the role of platelet activating factor (PAF) in the pathogenesis of a murine model of traumatic shock using WEB 2086, a specific antagonist of PAF. WEB 2086 (0.5 mg/kg) significantly reversed the decrease in mean arterial blood pressure (MABP) induced by PAF (0.3 micrograms/kg)...
|
PMID: 2718150
PDF is available here.
PDF is available here.
Eicosanoids (2)3 1989
Abstract
These results suggest that TxA2 may be an important mediator in traumatic shock, and that R-68070 may prove to be a useful therapeutic agent in this situation if given early in the course of the shock state....
|
PMID: 2534278
PDF is available here.
PDF is available here.
Abstract
In the present work the authors have tried to offer a vast and detailed summary of theories and questions concerning the role of the MDF in shock. One of the major problems that surrounds this molecule is the myocardial contractility depression, the solution of which could allow a more rationalistic...
|
PMID: 2699345
PDF is available here.
PDF is available here.
Intensive Care Medicine (15)2 1989
Abstract
The haemodynamic effects in the early phase of canine acute experimental pancreatitis (AP) were studied using a cardiac catheterization technique. AP was induced in anaesthetized dogs with an infusion of trypsin-sodium-taurocholate into the pancreatic duct. The initial haemodynamic measurements were...
|
PMID: 2715498
PDF is available here.
PDF is available here.
Abstract
Arzneimittel-Forschung (38)10 1988
Abstract
These results suggest that cardiotonic and vasodilator activities combined with inhibition of platelet aggregation could mediate the beneficial effects of pimobendan in traumatic shock....
|
PMID: 3196378
PDF is available here.
PDF is available here.
Resuscitation (16)3 1988
Abstract
The effects of a thromboxane receptor antagonist having lipoxygenase inhibitory activity, L-655,240 (3-[1-(4-chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]2,2-dimethylpropa noic acid) (1 mg/kg per h) were studied in a standardized model of traumatic shock. Pentobarbital (35 mg/kg) anesthetized rats sub...
|
PMID: 2845544
PDF is available here.
PDF is available here.
Abstract
We studied the effects of human superoxide dismutase (h-SOD) in splanchnic artery occlusion (SAO) shock. Pentobarbital anesthetized rats subjected to total occlusion of the superior mesenteric and the celiac arteries for 40 min developed a severe shock state usually resulting in a fatal outcome with...
|
PMID: 3393543
PDF is available here.
PDF is available here.
Abstract
We studied the effects of the thromboxane receptor antagonist, BM-13505, in rats during SAO shock. Anesthetized rats subjected to total occlusion of the celiac and superior mesenteric arteries for 40 minutes developed a severe shock state following reperfusion, usually resulting in death within 90-1...
|
PMID: 3419244
PDF is available here.
PDF is available here.
Abstract
We studied its effects in splanchnic artery occlusion (SAO) shock in rats. Anesthetized rats subjected to total occlusion of the celiac and superior mesenteric arteries for 40 minutes developed a severe shock state following reperfusion usually resulting in death 90-120 minutes after releasing the c...
|
PMID: 3175328
PDF is available here.
PDF is available here.
Abstract
We studied the effects of a potent, specific platelet activating factor (PAF) antagonist, CV-6209, in a murine model of hemorrhagic shock. Hemorrhaged rats treated with CV-6209 (1 mg/kg) maintained post-reinfusion mean arterial blood pressure (MABP) at significantly higher values than rats receiving...
|
PMID: 3409951
PDF is available here.
PDF is available here.
Abstract
We studied the effects of LY-163443, a novel selective receptor antagonist of LTD4 and LTE4, in splanchic artery occlusion (SAO) shock. LY-163443 antagonized the bronchoconstrictor effect of LTD4 given intravenously to anesthetized rats. Anesthetized rats subjected to total occlusion of the superior...
|
PMID: 3406041
PDF is available here.
PDF is available here.
Circulatory shock (24)3 1988
Abstract
We studied the effects of a novel selective peptide leukotriene antagonist, L-649,923, in a rat model of hemorrhagic shock. Hemorrhaged rats treated with L-649,923 (1 mg/kg/h) maintained post-reinfusion mean arterial blood pressure (MABP) at significantly higher values than rats receiving either 0.9...
|
PMID: 3383353
PDF is available here.
PDF is available here.
Prostaglandins (35)1 1988
Abstract
We studied the effects of CG-4203, a novel stable prostacyclin analog, in a severe model of traumatic shock in rats. Traumatic shock was produced by Noble Collip drum trauma and was characterized by marked hypotension, a 4- to 5-fold increase in plasma cathepsin D and myocardial depressant factor ac...
|
PMID: 3287456
PDF is available here.
PDF is available here.
Abstract
We have investigated the role of platelet activating factor (PAF) in the pathogenesis of a murine model of traumatic shock using CV-6209, a specific antagonist of PAF. CV-6209, at a dose of 1 mg/kg (i.v.) given after trauma, significantly improved survival rate at 150 min and overall survival time....
|
PMID: 2468048
PDF is available here.
PDF is available here.
Abstract
Abstract
Systemic acidosis has a negative inotropic effect on myocardial function, which in the intact animal, is counteracted by the activation of the sympathoadrenal system. Although there are extensive animal data in this field, human studies quantifying the influence of systemic acidosis on myocardial fu...
|
PMID: 3332222
PDF is available here.
PDF is available here.
Critical Care Medicine (15)8 1987
Abstract
The effects of prostaglandin E1 (PGE1) were studied in a standardized model of traumatic shock in rats. Pentobarbital anesthetized rats were subjected to standardized drum trauma of 525 revolutions in a Noble-Collip drum. These traumatized rats were characterized by a survival time of 108 +/- 19 min...
|
PMID: 3608533
PDF is available here.
PDF is available here.
Abstract
I throughout the shock period. CGS-13080 attenuated the increase in TxB2 plasma concentrations in shock when compared with hemorrhaged rats receiving the vehicle (P less than .05). Greater attenuation of TxB2 was found after treatment with the drug combination (P less than .01 from vehicle, P less t...
|
PMID: 3039116
PDF is available here.
PDF is available here.
Abstract
The effects of CGP 33304 and CGP 35949 were studied in standardized model of traumatic shock. Both drugs are dual leukotriene receptor antagonists and phospholipase A2 inhibiting agents. Pentobarbital anesthetized rats (35 kg/mg) subjected to Noble-Collip drum trauma were characterized by a 128 +/-...
|
PMID: 3613754
PDF is available here.
PDF is available here.
American Journal of Physiology -- Legacy Content (252)2 Pt 2 1987
Abstract
A variety of endogenously formed vasoconstrictor substances circulate in the blood and act as mediators in ischemia and shock states. These humoral substances are chemically diverse and include peptides, lipids, and aromatic amines. One of the novel peptides, myocardial depressant factor (MDF) and s...
|
PMID: 3544878
PDF is available here.
PDF is available here.