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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Opioid Peptides (3):
Recent article
Opioid Peptides
Abstract
Peripheral mechanisms of endogenous pain control are significant. In peripheral inflamed tissue, an interaction between immune-cell-derived opioids and opioid receptors localized on sensory nerve terminals results in potent, clinically measurable analgesia. Opioid peptides and the mRNA encoding thei...
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PMID: 20591509
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Movement Disorders (25)11 2010
Abstract
We investigated whether elevation of N/OFQ expression in 6-hydroxydopamine-hemilesioned rats selectively occurs in substantia nigra and whether hypomotility following acute haloperidol administration is accompanied by a rise in nigral N/OFQ levels. Moreover, to prove a link between N/OFQ and idiopat...
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PMID: 20589874
PDF is available here.
PDF is available here.
Biological Psychiatry (68)3 2010
Abstract
Biology of Reproduction (83)1 2010
Abstract
We presume that PNOC plays a role in regulating uterine contractility at term. Its effect is mediated partly by stimulatory heterotrimeric G (G(s)) proteins coupled to OPRL1 receptors and elevated cAMP levels, and also by Ca(2+)-dependent K(+) channels. Our results demonstrate a novel action and sig...
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PMID: 20237332
PDF is available here.
PDF is available here.
Abstract
This mini-review outlines the opioid systems and their roles primarily as related to reward and compulsive drug/alcohol intake. The central role is taken by the mu-opioid receptor, target for opiate analgesics and also a central target in compulsive alcohol abuse, alcoholism. The mu-opioid receptor...
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PMID: 20494127
PDF is available here.
PDF is available here.
Abstract
Based on template hexapeptides Ac-Arg-Tyr-Tyr-Arg-Trp-Lys-NH(2) and Ac-Arg-Tyr-Tyr-Arg-Ile-Lys-NH(2) analogues and corresponding deacylated homologues were synthesized substituting ornithine, diaminobutanoic (Dab) and diaminopropanoic (Dap) acids for lysine at position 6. The aim was to investigate...
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PMID: 19689226
PDF is available here.
PDF is available here.
Current Drug Targets (11)4 2010
Abstract
We review a great variety of behavioral models of drug addiction and alcohol-related behaviors. We also include data providing clear evidence that activation of the cannabinoid and opioid endogenous systems via WIN 55,512-2 (0.4-10 mg/kg) and morphine (1.0-10 mg/kg), respectively, produces similar l...
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PMID: 20196742
PDF is available here.
PDF is available here.
Abstract
We used quantitative real-time PCR (qRT-PCR) to measure mRNA levels of opioid peptide precursors and receptors in the brain and heart of summer ground squirrels (Ictidomys tridecemlineatus) and winter hibernating squirrels in the torpid or interbout arousal states. The use of appropriate reference g...
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PMID: 20033416
PDF is available here.
PDF is available here.
Abstract
Nociceptin/orphanin FQ (N/OFQ), added in vitro to murine spleen cells in the picomolar range, suppressed antibody formation to sheep red blood cells in a primary and a secondary plaque-forming cell assay. The activity of the peptide was maximal at 10(-12) M, with an asymmetric U-shaped dose-response...
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PMID: 20119853
PDF is available here.
PDF is available here.
Psychiatria polska (44)2 2010
Abstract
Neurobiology of the placebo effect dates back to 1978, when Levine discovered that its analgesic action is reversed by naloxone. Since then, various studies have been performed to estimate the impact of placebo on brain metabolism and neurotransmission in analgesia, depression or the Parkinson's dis...
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PMID: 20677441
PDF is available here.
PDF is available here.
Abstract
Opioid receptors and opioid peptides constitute the endogenous opioid system. The most relevant function of the opioid system seems to be the inhibitory modulation of nociceptive information at supraspinal, spinal and peripheral sites, although it is also implicated in the modulation of many other p...
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PMID: 20030621
PDF is available here.
PDF is available here.
Abstract
We compared the effect of NOP1 receptor agonist SCH486757 with matched placebo and codeine in a multicentre, double-blind, parallel-group study in patients with subacute cough. The primary outcome was change in cough severity scores, with the key secondary outcome change in objective daytime cough c...
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PMID: 19937046
PDF is available here.
PDF is available here.
Abstract
These results demonstrated that intrathecal UFP-112 produced long-lasting morphine-comparable antinociceptive effects without potential itch side effect. This study is the first to provide functional evidence that selective NOP receptor agonists such as UFP-112 alone or in conjunction with morphine...
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PMID: 19945794
PDF is available here.
PDF is available here.
Abstract
The opioid peptide H-Tyr-c[D-Cys-Phe-Phe-Cys]NH(2) cyclized via a methylene dithiother is a potent and selective mu opioid agonist (Przydial M.J. et al., J Peptide Res, 66, 2005, 255). Dicarba analogues of this peptide with Tyr, 2',6'-dimethyltyrosine (Dmt), 3-[2,6-dimethyl-4-hydroxy...
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PMID: 19694755
PDF is available here.
PDF is available here.
Abstract
Our findings show that unstable angina is associated with a significant increase in circulating N/OFQ levels unrelated to intervening transient myocardial ischemia or hemodynamic changes. This increase is probably related to the chest pain repeatedly occurring in the course of coronary artery diseas...
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PMID: 19560501
PDF is available here.
PDF is available here.
Abstract
Since their discovery in the brain and gastrointestinal tract nearly 40 years ago, endogenous opioid peptides have been progressively shown to play a role in the regulation of food intake. Animal and human studies regarding opioid peptides and ingestive behavior are reviewed. While the opioid recept...
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PMID: 19537999
PDF is available here.
PDF is available here.
Abstract
These results suggest that nociceptin in the spinal cord mediates part of the EA-related modulation of visceral reflex responses....
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PMID: 19561314
PDF is available here.
PDF is available here.
Gastroenterology (137)2 2009
Abstract
Solitary chemosensory cells that coexpress beta-endorphin, Met-enkephalin, uroguanylin, and Trpm5 exist in mouse duodenum. These cells are likely to secrete the bioactive peptides into the intestinal lumen in response to dietary factors; release of the opioid peptides requires the Trpm5 ion channel....
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PMID: 19272386
PDF is available here.
PDF is available here.
International Journal of Obesity (33 Suppl 2) 2009
Abstract
Humans eat for many reasons, including the rewarding qualities of foods. A host of neurotransmitters have been shown to influence eating behavior and some of these appear to be involved in reward-induced eating. Endogenous opioid peptides and their receptors were first reported more than 30 years ag...
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PMID: 19528981
PDF is available here.
PDF is available here.
Journal of Hypertension (27)6 2009
Abstract
The putative antihypertensive effect of milk after fermentation by lactic bacteria has attracted attention over the past 20 years. Research on fermented milk and hypertension has mainly focused on the content of peptides with in-vitro angiotensin converting enzyme-inhibitor effect. However, fermente...
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PMID: 19387365
PDF is available here.
PDF is available here.
Abstract
Abstract
Several studies indicated that stress would induce analgesia. Noise, one of the stressors, was assumed to be one of the elements to enhance the threshold of pain tolerance. Since noise might affect human's daily life, it is important to know the mechanism underlying this phenomenon. The objective of...
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PMID: 19764344
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (89)13 2009
Abstract
The plasma OFQ level of the BD group was (20+/-4) ng/L, significantly higher than that of the control group [(14+/-5) ng/L, t=5.28, P<0.01], and the OFQ level of the BM group was (11+/-3) ng/L, significantly lower than that of the control group (t=-2.47, P<0.05). There were not significant differenc...
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PMID: 19671295
PDF is available here.
PDF is available here.
Abstract
We observed that N/OFQ-induced hyperphagia is greater in DA rats, animals resistant to metabolic syndrome, than in WOKW animals, which are prone to this disease. We attributed this difference to the fact that these two strains have different Cart gene sequences and expression. As a preliminary appro...
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PMID: 19070636
PDF is available here.
PDF is available here.
Abstract
We observed that N/OFQ-induced hyperphagia is greater in DA rats, animals resistant to metabolic syndrome, than in WOKW animals, which are prone to this disease. We attributed this difference to the fact that these two strains have different Cart gene sequences and expression. As a preliminary appro...
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PMID: 19070636
PDF is available here.
PDF is available here.
Abstract
These results suggest that the anti-opioid effects of AT(2) agonists are mediated by the PGE(2)-EP(3) receptor system downstream of the AT(2) receptor....
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PMID: 19084563
PDF is available here.
PDF is available here.
Abstract
These results suggest that the anti-opioid effects of AT(2) agonists are mediated by the PGE(2)-EP(3) receptor system downstream of the AT(2) receptor....
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PMID: 19084563
PDF is available here.
PDF is available here.
Abstract
We observed that N/OFQ-induced hyperphagia is greater in DA rats, animals resistant to metabolic syndrome, than in WOKW animals, which are prone to this disease. We attributed this difference to the fact that these two strains have different Cart gene sequences and expression. As a preliminary appro...
|
PMID: 19070636
PDF is available here.
PDF is available here.
Abstract
These results suggest that the anti-opioid effects of AT(2) agonists are mediated by the PGE(2)-EP(3) receptor system downstream of the AT(2) receptor....
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PMID: 19084563
PDF is available here.
PDF is available here.
Abstract
We observed that N/OFQ-induced hyperphagia is greater in DA rats, animals resistant to metabolic syndrome, than in WOKW animals, which are prone to this disease. We attributed this difference to the fact that these two strains have different Cart gene sequences and expression. As a preliminary appro...
|
PMID: 19070636
PDF is available here.
PDF is available here.
Abstract
These results suggest that the anti-opioid effects of AT(2) agonists are mediated by the PGE(2)-EP(3) receptor system downstream of the AT(2) receptor....
|
PMID: 19084563
PDF is available here.
PDF is available here.
Abstract
We observed that N/OFQ-induced hyperphagia is greater in DA rats, animals resistant to metabolic syndrome, than in WOKW animals, which are prone to this disease. We attributed this difference to the fact that these two strains have different Cart gene sequences and expression. As a preliminary appro...
|
PMID: 19070636
PDF is available here.
PDF is available here.
Abstract
These results suggest that the anti-opioid effects of AT(2) agonists are mediated by the PGE(2)-EP(3) receptor system downstream of the AT(2) receptor....
|
PMID: 19084563
PDF is available here.
PDF is available here.
Abstract
We observed that N/OFQ-induced hyperphagia is greater in DA rats, animals resistant to metabolic syndrome, than in WOKW animals, which are prone to this disease. We attributed this difference to the fact that these two strains have different Cart gene sequences and expression. As a preliminary appro...
|
PMID: 19070636
PDF is available here.
PDF is available here.
Abstract
These results suggest that the anti-opioid effects of AT(2) agonists are mediated by the PGE(2)-EP(3) receptor system downstream of the AT(2) receptor....
|
PMID: 19084563
PDF is available here.
PDF is available here.
Abstract
We observed that N/OFQ-induced hyperphagia is greater in DA rats, animals resistant to metabolic syndrome, than in WOKW animals, which are prone to this disease. We attributed this difference to the fact that these two strains have different Cart gene sequences and expression. As a preliminary appro...
|
PMID: 19070636
PDF is available here.
PDF is available here.
Abstract
These results suggest that the anti-opioid effects of AT(2) agonists are mediated by the PGE(2)-EP(3) receptor system downstream of the AT(2) receptor....
|
PMID: 19084563
PDF is available here.
PDF is available here.
Abstract
We observed that N/OFQ-induced hyperphagia is greater in DA rats, animals resistant to metabolic syndrome, than in WOKW animals, which are prone to this disease. We attributed this difference to the fact that these two strains have different Cart gene sequences and expression. As a preliminary appro...
|
PMID: 19070636
PDF is available here.
PDF is available here.
Abstract
These results suggest that the anti-opioid effects of AT(2) agonists are mediated by the PGE(2)-EP(3) receptor system downstream of the AT(2) receptor....
|
PMID: 19084563
PDF is available here.
PDF is available here.
Abstract
We observed that N/OFQ-induced hyperphagia is greater in DA rats, animals resistant to metabolic syndrome, than in WOKW animals, which are prone to this disease. We attributed this difference to the fact that these two strains have different Cart gene sequences and expression. As a preliminary appro...
|
PMID: 19070636
PDF is available here.
PDF is available here.
Abstract
These results suggest that the anti-opioid effects of AT(2) agonists are mediated by the PGE(2)-EP(3) receptor system downstream of the AT(2) receptor....
|
PMID: 19084563
PDF is available here.
PDF is available here.
Abstract
We observed that N/OFQ-induced hyperphagia is greater in DA rats, animals resistant to metabolic syndrome, than in WOKW animals, which are prone to this disease. We attributed this difference to the fact that these two strains have different Cart gene sequences and expression. As a preliminary appro...
|
PMID: 19070636
PDF is available here.
PDF is available here.
Abstract
These results suggest that the anti-opioid effects of AT(2) agonists are mediated by the PGE(2)-EP(3) receptor system downstream of the AT(2) receptor....
|
PMID: 19084563
PDF is available here.
PDF is available here.
Abstract
We observed that N/OFQ-induced hyperphagia is greater in DA rats, animals resistant to metabolic syndrome, than in WOKW animals, which are prone to this disease. We attributed this difference to the fact that these two strains have different Cart gene sequences and expression. As a preliminary appro...
|
PMID: 19070636
PDF is available here.
PDF is available here.
Abstract
These results suggest that the anti-opioid effects of AT(2) agonists are mediated by the PGE(2)-EP(3) receptor system downstream of the AT(2) receptor....
|
PMID: 19084563
PDF is available here.
PDF is available here.
Abstract
We observed that N/OFQ-induced hyperphagia is greater in DA rats, animals resistant to metabolic syndrome, than in WOKW animals, which are prone to this disease. We attributed this difference to the fact that these two strains have different Cart gene sequences and expression. As a preliminary appro...
|
PMID: 19070636
PDF is available here.
PDF is available here.
Abstract
We observed that N/OFQ-induced hyperphagia is greater in DA rats, animals resistant to metabolic syndrome, than in WOKW animals, which are prone to this disease. We attributed this difference to the fact that these two strains have different Cart gene sequences and expression. As a preliminary appro...
|
PMID: 19070636
PDF is available here.
PDF is available here.
Abstract
These results suggest that the anti-opioid effects of AT(2) agonists are mediated by the PGE(2)-EP(3) receptor system downstream of the AT(2) receptor....
|
PMID: 19084563
PDF is available here.
PDF is available here.
Abstract
These results suggest that the anti-opioid effects of AT(2) agonists are mediated by the PGE(2)-EP(3) receptor system downstream of the AT(2) receptor....
|
PMID: 19084563
PDF is available here.
PDF is available here.
Abstract
We observed that N/OFQ-induced hyperphagia is greater in DA rats, animals resistant to metabolic syndrome, than in WOKW animals, which are prone to this disease. We attributed this difference to the fact that these two strains have different Cart gene sequences and expression. As a preliminary appro...
|
PMID: 19070636
PDF is available here.
PDF is available here.
Abstract
These results suggest that the anti-opioid effects of AT(2) agonists are mediated by the PGE(2)-EP(3) receptor system downstream of the AT(2) receptor....
|
PMID: 19084563
PDF is available here.
PDF is available here.
Abstract
We observed that N/OFQ-induced hyperphagia is greater in DA rats, animals resistant to metabolic syndrome, than in WOKW animals, which are prone to this disease. We attributed this difference to the fact that these two strains have different Cart gene sequences and expression. As a preliminary appro...
|
PMID: 19070636
PDF is available here.
PDF is available here.
Abstract
These results suggest that the anti-opioid effects of AT(2) agonists are mediated by the PGE(2)-EP(3) receptor system downstream of the AT(2) receptor....
|
PMID: 19084563
PDF is available here.
PDF is available here.
Abstract
We observed that N/OFQ-induced hyperphagia is greater in DA rats, animals resistant to metabolic syndrome, than in WOKW animals, which are prone to this disease. We attributed this difference to the fact that these two strains have different Cart gene sequences and expression. As a preliminary appro...
|
PMID: 19070636
PDF is available here.
PDF is available here.
Abstract
These results suggest that the anti-opioid effects of AT(2) agonists are mediated by the PGE(2)-EP(3) receptor system downstream of the AT(2) receptor....
|
PMID: 19084563
PDF is available here.
PDF is available here.
Abstract
We observed that N/OFQ-induced hyperphagia is greater in DA rats, animals resistant to metabolic syndrome, than in WOKW animals, which are prone to this disease. We attributed this difference to the fact that these two strains have different Cart gene sequences and expression. As a preliminary appro...
|
PMID: 19070636
PDF is available here.
PDF is available here.
Abstract
These results suggest that the anti-opioid effects of AT(2) agonists are mediated by the PGE(2)-EP(3) receptor system downstream of the AT(2) receptor....
|
PMID: 19084563
PDF is available here.
PDF is available here.
Abstract
We observed that N/OFQ-induced hyperphagia is greater in DA rats, animals resistant to metabolic syndrome, than in WOKW animals, which are prone to this disease. We attributed this difference to the fact that these two strains have different Cart gene sequences and expression. As a preliminary appro...
|
PMID: 19070636
PDF is available here.
PDF is available here.
Abstract
These results suggest that the anti-opioid effects of AT(2) agonists are mediated by the PGE(2)-EP(3) receptor system downstream of the AT(2) receptor....
|
PMID: 19084563
PDF is available here.
PDF is available here.
Abstract
We observed that N/OFQ-induced hyperphagia is greater in DA rats, animals resistant to metabolic syndrome, than in WOKW animals, which are prone to this disease. We attributed this difference to the fact that these two strains have different Cart gene sequences and expression. As a preliminary appro...
|
PMID: 19070636
PDF is available here.
PDF is available here.