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Peptides, Cyclic (21):
Recent article
Peptides, Cyclic
Oligonucleotides (21)2 2011
Abstract
We previously reported an angiogenic endothelial cell-targeted polymeric gene carrier, PEI-g-PEG-RGD. This targeted carrier was developed by the conjugation of the ανβ3/ανβ5 integrin-binding RGD peptide (ACDCRGDCFC) to the cationic polymer, branched polyethylenimine, with a hydrophilic polyeth...
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PMID: 21375397
PDF is available here.
PDF is available here.
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Cancer Science (102)3 2010
Abstract
We focused on the hypoxia-selective cytotoxin, Rakicidin A. A previous report showed that Rakicidin A, a natural product produced by the Micromonospora strain, induced hypoxia-selective cytotoxicity in solid tumors. Here, we describe Rakicidin A-induced cell death in hypoxia-adapted (HA)-CML cells w...
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PMID: 21166958
PDF is available here.
PDF is available here.
Abstract
The Mycobacterium tuberculosis enzyme Rv2275 catalyzes the formation of cyclo(L-Tyr-L-Tyr) using two molecules of Tyr-tRNA(Tyr) as substrates. The three-dimensional (3D) structure of Rv2275 was determined to 2.0-Å resolution, revealing that Rv2275 is structurally related to the class Ic aminoacyl-t...
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PMID: 20852636
PDF is available here.
PDF is available here.
Abstract
Journal of Antibiotics (63)11 2010
Abstract
We screened actinomycetes capable of converting AS1387392 to AS1429716 and identified those strains capable of hydroxylation. Amycolatopsis azurea JCM 3275 was found to be a particularly efficient strain, capable of converting AS1387392 to AS1429716, with a yield of 44% after 9 h. This strain can...
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PMID: 20924384
PDF is available here.
PDF is available here.
Journal of Antibiotics (63)11 2010
Abstract
We identified 12 strains capable of efficient hydroxylation. Results of phylogenetic analysis of 16S rDNA sequences suggested that these strains belonged to the genera Lentzea, Saccharopolyspora, Sphaerisporangium and Amycolatopsis. Morphological and chemical characteristics as well as results of ph...
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PMID: 20664604
PDF is available here.
PDF is available here.
Journal of Antibiotics (63)11 2010
Abstract
The novel immunosuppressant AS1387392 has been isolated from Acremonium sp. No. 27082. This compound showed a strong inhibitory effect against mammalian histone deacetylase and T-cell proliferation. Further, AS1387392 showed a good oral absorption, and its plasma concentration was higher than that o...
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PMID: 20588300
PDF is available here.
PDF is available here.
Journal of Antibiotics (63)11 2010
Abstract
We cloned an entire novel P450 gene (1209 bp) and named it P450Um-1. Its deduced amino acid sequence was homologous with that of the CYP105 subfamily. Further cloning of the upstream region, which may contain the native promoter site, was followed by insertion of the open reading frame with the up...
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PMID: 20924385
PDF is available here.
PDF is available here.
Chemical Communications (46)38 2010
Abstract
Cyclic RGD-peptide functionalized phospholipids micelle-encapsulated near-infrared CdTe/ZnSe quantum dots were synthesized as multifunctional probes for targeting and imaging tumors in live animals.
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PMID: 20820500
PDF is available here.
PDF is available here.
Abstract
We review and compare the pharmacokinetic and clinical efficacy of lanreotide, the second SSA available in the market, in its different formulations.
This article concisely reviews the rationale of SSA treatment in acromegaly and the pharmacology and clinical efficacy of lanreotide and provides a de...
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PMID: 20716034
PDF is available here.
PDF is available here.
Abstract
We aimed to determine whether immunoglobulin-A nephropathy (IgAN) could be induced in Balb/c mice by immunizing them with a fusion protein (MBP-20 peptide) comprising the maltose-binding protein (MBP) and a 20-amino-acid peptide derived from Staphylococcus aureus. A recombinant plasmid encoding the...
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PMID: 20730864
PDF is available here.
PDF is available here.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology (21)3 2010
Abstract
We aimed to test the effects of a long-acting somatostatin analogue, lanreotide, on bile duct ligation-induced liver fibrosis in rats.
Thirty-seven Wistar rats were divided into 5 groups as follows: Group 1, bile duct ligation+lanreotide; Group 2, bile duct ligation; Group 3, sham+lanreotide; Group...
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PMID: 20931434
PDF is available here.
PDF is available here.
Biopolymers (93)9 2010
Abstract
The bisintercalator natural products are a family of nonribosomal peptides possessing a range of biological properties that include antiviral, antibiotic, and anticancer activities. The name bisintercalator is derived from the ability to directly bind to duplex DNA through two planar intercalating m...
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PMID: 20578002
PDF is available here.
PDF is available here.
Journal of Antibiotics (63)9 2010
Abstract
Chemical Communications (46)31 2010
Abstract
A unique method has been developed for the formation of multivalent cyclic peptides. This procedure exploits on-resin peptide cyclization using a photoinitiated thiol-ene click reaction and subsequent clustering using thiol-yne photochemistry. Both reactions utilize the sulfhydryl group on natural c...
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PMID: 20552127
PDF is available here.
PDF is available here.
Abstract
We performed a genome-wide haplotype association study and prioritized RA-related genes within 100 kb in either direction of significant haplotypes (P < 0.0001), based on their similarity to known RA susceptibility genes. The results showed that the chemokine CCL3 was associated with susceptibility...
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PMID: 20518837
PDF is available here.
PDF is available here.
Microcirculation (17)6 2010
Abstract
We measured responses of cerebral arterioles in non-diabetic rats to endothelial nitric oxide synthase (eNOS)-dependent (ADP), neuronal nitric oxide synthase (nNOS)-dependent (N-methyl-d-aspartic acid [NMDA]) and NOS-independent (nitroglycerin) agonists before and during application of BQ-123, an ET...
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PMID: 20690982
PDF is available here.
PDF is available here.
Cancer Letters (295)1 2010
Abstract
We have investigated the mechanisms of apoptotic effects of FR235222 in LNCaP cell line and the role of ANXA1. We showed that treatment with FR235222 induced apoptosis through a caspase-dependent mechanism. FR235222 was able to increase the protein levels of ANXA1 at a transcriptional level. Finally...
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PMID: 20227822
PDF is available here.
PDF is available here.
Abstract
Anti-CCP antibodies, in relation to HLA-DRB1*SE carriership, and PIP involvement are predictive for the development of RA from PR in the Japanese population....
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PMID: 20476860
PDF is available here.
PDF is available here.
Circulation Research (107)2 2010
Abstract
The stimulated exocytotic release of ET-1 is dramatically increased in aged endothelium. This reflects increased reactivity of exocytosis, increased expression and storage of ET-1 precursor peptides, and increased expression of ECE-1. Altered endothelial exocytosis of ET-1 and other mediators may co...
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PMID: 20522806
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)30 2010
Abstract
We tested the ability of a library of small peptidomimetics to induce phenotypic effects with functional implications on a panel of strains of the budding yeast Saccharomyces cerevisiae, both wild type and mutants, for respiratory function and multidrug resistance. Further elucidation of the functio...
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PMID: 20501664
PDF is available here.
PDF is available here.
Abstract
We report the mode of action of theonellamides, bicyclic peptides derived from marine sponges. We generated a chemical-genomic profile of theonellamide F using a collection of fission yeast strains in which each open reading frame (ORF) is expressed under the control of an inducible promoter. Cluste...
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PMID: 20543850
PDF is available here.
PDF is available here.
Endocrinology (151)7 2010
Abstract
We investigated here whether somatostatin has direct effects on GnRH neurons in the adult male and female mice. Dual-labeling immunofluorescence experiments revealed the presence of somatostatin-immunoreactive fibers adjacent to GnRH neurons, and three-dimensional confocal reconstructions demonstrat...
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PMID: 20410192
PDF is available here.
PDF is available here.
Abstract
We tested whether MTII would increase these intracellular markers of lipolysis. Male Siberian hamsters received a single 3rd ventricular injection of MTII or saline. Trunk blood was collected at 0.5, 1.0, and 2.0 h postinjection from excised inguinal, retroperitoneal, and epididymal WAT (IWAT, RWAT,...
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PMID: 20410474
PDF is available here.
PDF is available here.
Parasitology Research (107)2 2010
Abstract
Nosemosis, a disease caused by a microsporidian infection, is one of the most frequently observed parasitic pathologies affecting adult honeybees. Presently, Nosema ceranae seems to be the main microsporidian infection in Apis mellifera. The antibiotic fumagillin is the only compound available to tr...
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PMID: 20467753
PDF is available here.
PDF is available here.
Abstract
Higher aCCP concentrations (particularly in RF-positive patients) are associated with increased disease activity in US veterans with RA, indicating that aCCP concentration is predictive of future disease outcomes in men....
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PMID: 20439294
PDF is available here.
PDF is available here.
Abstract
To develop a matrix model for the prediction of rapid radiographic progression (RRP) in subpopulations of patients with recent-onset rheumatoid arthritis (RA) receiving different dynamic treatment strategies.
Data from 465 patients with recent-onset RA randomised to r...
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PMID: 20498212
PDF is available here.
PDF is available here.
Journal of Bacteriology (192)14 2010
Abstract
We present evidence that cyclo(Phe-Pro) inhibits the production of the virulence factors cholera toxin (CT) and toxin-coregulated pilus (TCP) in O1 El Tor Vibrio cholerae strain N16961 during growth under virulence gene-inducing conditions. The cyclo(Phe-Pro) inhibition of CT and TCP production corr...
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PMID: 20453095
PDF is available here.
PDF is available here.
Journal of Antibiotics (63)7 2010
Abstract
Abstract
Pseudallescheria boydii sensu lato is an emerging fungal pathogen causing fatal infections in both immunocompromised and immunocompetent hosts. In this work, two P. boydii isolates (human and animal origin) have been identified as being producers of cyclic peptides. Five putative nonribosomal peptid...
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PMID: 20509707
PDF is available here.
PDF is available here.
Abstract
Three new bastadins, bastadin 25 (1), 15-O-sulfonatobastadin 11 (2), and bastadin 26 (3), were isolated from a MeOH extract of the Australian marine sponge Ianthella flabelliformis. Their structures were determined by interpretation of 1D and 2D NMR spectra and mass spectrometry. Bastadin 26 (3) sho...
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PMID: 20575589
PDF is available here.
PDF is available here.
Abstract
I (9) and JBIR-15 (12) showed selective antifungal activity against Candida albicans with MIC values of 7.5, 3.8, 30, 6.7, and 30 microM, respectively....
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PMID: 20503985
PDF is available here.
PDF is available here.
Abstract
We show that a strain of the single-celled, planktonic marine cyanobacterium Prochlorococcus-which conducts a sizable fraction of photosynthesis in the oceans-produces many cyclic, lanthionine-containing peptides (lantipeptides). Remarkably, in Prochlorococcus MIT9313 a single promiscuous enzyme tra...
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PMID: 20479271
PDF is available here.
PDF is available here.
Abstract
Abstract
The post-CP/CPB contractile response of coronary arterioles to ET-1 was significantly decreased compared with the pre-CP/CPB responses. The response to ET-1 was significantly inhibited in the presence of the ET-A antagonist BQ123 (10(-7)mol/L), but these values remained unchanged with the ET-B recep...
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PMID: 20079914
PDF is available here.
PDF is available here.
Diabetic Medicine (27)6 2010
Abstract
Microbial Pathogenesis (48)6 2010
Abstract
Our data indicate that, in a qseC mutant, the QseB response regulator decreases motility and swine colonization; inactivation of the qseBC operon restores these bacterial phenotypes, classifying QseB as a negative regulator of bacterial motility and swine colonization.
Published by Elsevier India Pv...
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PMID: 20227482
PDF is available here.
PDF is available here.
Abstract
Four new minor constituents including two cyclodipeptides (1 and 2) and two cyclopentene derivatives (3 and 4), together with four known cyclodipeptides, have been isolated from an ethanolic extract of the tubers of Gymnadenia conopsea. Their structures including absolute configurations were determi...
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PMID: 20552487
PDF is available here.
PDF is available here.
Journal of Rheumatology (37)6 2010
Abstract
Autoantibody frequency in patients with RA and relatives: ACPA 91% vs 19%, respectively; IgM RF 82% vs 17%; IgA RF 48% vs 22%. Anti-P. gingivalis levels were higher in patients with RA compared to relatives and controls (p = 0.005) and higher in ACPA-positive patients with RA than in ACPA-negative p...
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PMID: 20436074
PDF is available here.
PDF is available here.
Journal of Rheumatology (37)6 2010
Abstract
PIIANP was low at diagnosis and 4 years on (p < 0.001), irrespective of treatment and disease activity. PIIANP was lowest in anti-CCP positive patients (p = 0.006), and there was a negative correlation between PIIANP and anti-CCP titers (rho = -0.25, p 0.002). CTX-II was increased (p < 0.001) and co...
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PMID: 20436079
PDF is available here.
PDF is available here.
Biophysical Chemistry (149)1-2 2010
Abstract
We present direct structural evidence from cryo-electron tomography data that thread-like micelles with a uniform diameter of 6.5 nm are organized into loops of different sizes at a surfactin concentration of > 15 mol%.
2010 Elsevier B.V. All rights reserved....
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PMID: 20406718
PDF is available here.
PDF is available here.
Neuropeptides (44)3 2010
Abstract
The effect of tachykinin neurokinin NK(2) receptors activation on intestinal propulsion and colorectal sensitivity was studied in 7-15 days old newborn rats. In a first set of experiments investigating the intestinal transit, the selective NK(2) receptor agonist, [betaAla(8)]NKA-(4-10) was used. It...
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PMID: 20137809
PDF is available here.
PDF is available here.
Abstract
These results suggest that urocortin 1 prevents indomethacin-induced small intestinal lesions, and that this action is mediated by the activation of CRFR2 and is functionally associated with the suppression of the intestinal hypermotility response caused by indomethacin. It is assumed that endogenou...
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PMID: 19707872
PDF is available here.
PDF is available here.
Abstract
Anti-CCP positivity was significantly correlated with more severe joint damage at diagnosis. A correlation was observed between the radiological joint damage score and inflammatory parameters in early and established RA, indicating that anti-CCP can serve as a diagnostic tool and predict structural...
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PMID: 20526395
PDF is available here.
PDF is available here.
Abstract
Patients with GRS >1.25 SD of the mean had a significantly higher OR of seropositive RA in both NHS (OR=2.9, 95%CI 1.8 to 4.6) and EIRA (OR 3.4, 95% CI 2.3 to 5.0) referent to the population average. In NHS, the AUC for a clinical model was 0.57 and for a clinical plus genetic model was 0.66, and in...
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PMID: 20233754
PDF is available here.
PDF is available here.
Abstract
FCGR3A is a risk factor for the development of autoantibody positive RA, particularly in men, with evidence of a multiplicative effect with HLA-DRB1 SE....
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PMID: 19700393
PDF is available here.
PDF is available here.
Abstract
Silica-exposed subjects were found to have a moderately increased risk of ACPA-positive RA (odds ratio (OR) adjusted for age and residency=1.67 (95% CI 1.13 to 2.48), but not of ACPA-negative RA (OR=0.98 (95% CI 0.57 to 1.66)), compared with subjects unexposed to silica. SUBJECTS: exposed to rock dr...
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PMID: 19966090
PDF is available here.
PDF is available here.
Abstract
The magnitude of the ACPA isotype profile at baseline reflects the risk of future radiographic damage. These results indicate that the presence and the constitution of the ACPA response are relevant to the disease course of RA....
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PMID: 20439289
PDF is available here.
PDF is available here.
Journal of Antibiotics (63)6 2010
Abstract
The time-kill studies using pargamicin A against Staphylococcus aureus and Enterococcus faecalis were performed. The effects of the incorporation of radioactive precursors into macromolecules, membrane potential and function using fluorescent dyes were also examined. These studies revealed that rapi...
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PMID: 20339400
PDF is available here.
PDF is available here.
Abstract
We describe an entirely new way of presenting of this peptide based on its attachment to a cyclopeptide RAFT scaffold (K-K-K-P-G)(2) through the epsilon-amino group of lysine residues, alone or in combination with the carbohydrate epitope alphaGalNAc. The ability of such RAFT scaffolds to precipitat...
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PMID: 20420392
PDF is available here.
PDF is available here.
Abstract
Two cyclopeptidic Smac mimetics, 2 and 3, were designed and synthesized. These two compounds bind to XIAP and cIAP-1/2 with low nanomolar affinities, and restore the activities of caspase-9 and caspase-3/-7 inhibited by XIAP. Compound 2 potently inhibits cancer cell growth and is 5-8 times more pote...
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PMID: 20443226
PDF is available here.
PDF is available here.
Abstract
We evaluate the sensitivity and cross-reactivity of the commercially produced ImmunoStrip) and apply them to the detection of microcystins in laboratory cultures and natural samples. It was observed that while the ImmunoStrip) are marketed for the detection of 10 microg/l microcystin, all 7 microcys...
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PMID: 19505489
PDF is available here.
PDF is available here.
Abstract
Somatostatin analogs (SA) are the cornerstone in the medical treatment of acromegaly, used as either primary or adjunctive therapy. In particular, SA are effective in inducing the biochemical remission of the disease and tumor shrinkage, although only few cases of complete disappeara...
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PMID: 20156970
PDF is available here.
PDF is available here.
Abstract
We will discuss the physiological and pathophysiological role of endothelium-derived ET-1 focusing on the regulation of the vascular tone, and as much as possible in humans. The coronary bed will be used as a running example in this review because it is the most susceptible to endothelial dysfunctio...
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PMID: 19967386
PDF is available here.
PDF is available here.
Abstract
We discuss the historical background of anti-CCP as well as its diagnostic performance, usefulness for early diagnosis, prognostic capability, and pathogenesis of RA....
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PMID: 20560456
PDF is available here.
PDF is available here.
Abstract
We recently demonstrated that in monocyte/macrophage-like U937 cells, extracellular nucleotides heterologously desensitize CysLT(1) receptor (CysLT(1)R)-induced Ca(2+) transients. Given that monocytes express a number of other inflammatory and chemoattractant receptors, this study was aimed at chara...
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PMID: 19965602
PDF is available here.
PDF is available here.
Abstract
We established wild-type MIC distributions on Middlebrook 7H10 medium for amikacin, kanamycin, streptomycin, capreomycin, and viomycin using 90 consecutive clinical isolates and 21 resistant strains. Overall, the MIC variation between and within runs did not exceed +/-1 MIC dilution step, and valida...
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PMID: 20237102
PDF is available here.
PDF is available here.
Amino Acids (38)5 2010
Abstract
We present the in vivo biosynthesis of wild-type sunflower trypsin inhibitor 1 (SFTI-1) inside E. coli cells using an intramolecular native chemical ligation in combination with a modified protein splicing unit. SFTI-1 is a small backbone cyclized polypeptide with a single disulfide bridge. A small...
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PMID: 19685144
PDF is available here.
PDF is available here.
Abstract
Journal of Chromatography A (1217)18 2010
Abstract
I was developed. After evaluating mobile phase compositions on the retention characteristics by reversed phase high-performance liquid chromatography (HPLC), the elution order of nocathiacin I and nocathiacin acid was completely reversed, and the resolution value between the two analogues was improv...
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PMID: 20303091
PDF is available here.
PDF is available here.