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Polygeline (0):
Recent article
Polygeline
Journal of Critical Care (25)2 2010
Abstract
Thirty hypovolemic patients (intrathoracic blood volume index, <850 mL/m(2)) were randomized into hydroxyethyl starch (mean molecular weight, 130,000 Da) and polygeline (mean molecular weight, 30,000 Da) groups (15 patients each). Indocyanine green plasma disappearance elimination (ICG-PDR) were con...
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PMID: 19682845
PDF is available here.
PDF is available here.
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Critical Care Medicine (38)2 2010
Abstract
The effects of Gelofusine and Voluven were similar despite the 100 kD difference in weight-average molecular weight. Excretion of an acute fluid load containing sodium and chloride may be dependent on a sustained suppression of the renin-angiotensin-aldosterone system rather than on natriuretic pept...
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PMID: 19789444
PDF is available here.
PDF is available here.
Abstract
We compared haemodilution acid-base effects of 4% albumin, 3.5% polygeline, 4% succinylated gelatin (all weak acid colloids, strong ion difference 12 mEq/l, 17.6 mEq/l and 34 mEq/l respectively), 6% hetastarch (non-weak acid colloid, strong ion difference zero) and 0.9% saline (crystalloid, strong i...
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PMID: 19499860
PDF is available here.
PDF is available here.
Acta medica Indonesiana (41)2 2009
Abstract
Acta medica Indonesiana (41)2 2009
Abstract
There were 43 subjects who completely participated in this study and included in analysis. From baseline levels, haematocrite decreased in first 6 hours during fluid treatment. This decrement persisted in 48 hours of observation. Statistical analysis with ANOVA test showed the significant difference...
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PMID: 19390121
PDF is available here.
PDF is available here.
Abstract
Abstract
We describe a severe anaphylactic reaction to Gelofusin, used as part of a transthoracic echo study on a middle-aged woman who had suffered a prior cerebral event.
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PMID: 17175200
PDF is available here.
PDF is available here.
Abstract
Abstract
Nuklearmedizin (47)3 2008
Abstract
We conclude that rat kidney uptake of radiolabelled somatostatin analogues can be monitored for a longer period in the same animal using animal SPECT. Gelofusine and lysine had equal potential to reduce kidney uptake of therapeutic doses of [177Lu-DOTA0,Tyr3]octreotate. The combination of these comp...
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PMID: 18493690
PDF is available here.
PDF is available here.
Abstract
The aim of the study was to assess the use of gelofusine and voluven for acute normovolemic hemodilution at cardiac surgery under extracorporeal circulation (EC). Sixty-seven patients with coronary heart disease were examined. Heart rate, total peripheral vascular resistance, pulmonary pressure, pul...
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PMID: 18652167
PDF is available here.
PDF is available here.
Abstract
We identified two different electrolyte solutions used in clinical practice for amnioinfusion. We identified four additional commercially available solutions that could potentially be used for amnioinfusion. Most of these infusion solutions differ considerably from midtrimester amniotic fluid sample...
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PMID: 18645255
PDF is available here.
PDF is available here.
Abstract
Abstract
This study shows a lower need for plasma expanders in patients who receive only starch plasma expanders. Further, we noted a lower COP in the LMSRL group, but since the mean COP was >17 +/- 0.2 mmHg, this cannot be considered of clinical importance. In conclusion, our study result supports the use o...
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PMID: 18416219
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (87)27 2007
Abstract
Compared with the time point of immediately before CPB (T(0)), The S100B protein level of the 2 groups began to increase since the time point T(1), peaked at the time point T(2), began to decrease gradually since the time point T(3), and were still significantly higher than those before CPB at the t...
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PMID: 17923015
PDF is available here.
PDF is available here.
Abstract
Although the incidence of hearing loss for the lactated Ringer's group was higher than the Gelofusine group, there was no statistically significant difference between the groups. For medicolegal and ethical reasons, patients should be informed about the possibility of hearing loss after spinal anest...
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PMID: 17599570
PDF is available here.
PDF is available here.
Presse Medicale (36)6 Pt 1 2007
Abstract
The economic analysis included all patients in the efficacy population (group receiving human albumin 20%: n=30, polygeline group: n=38). It found a standardized cost per patient for 30 days of treatment that was significantly lower (p=0.004) for human albumin 20% (median: 1915 euro; range: 1330-410...
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PMID: 17379475
PDF is available here.
PDF is available here.
Abstract
OCT accumulation in the kidney was inhibited by Lys and GF (40.7%-45.1%), whereas PGA was ineffective. On the other hand, renal uptake of BOM, MG, and EX was inhibited by PGA and GF (15.4%-85.4%), whereas Lys was ineffective. The combination of GF and Lys showed additive effects in inhibiting OCT up...
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PMID: 17401097
PDF is available here.
PDF is available here.
Journal of Clinical Gastroenterology (41 Suppl 3) 2007
Abstract
We investigated effects of reduced blood viscosity on the hyperdynamic circulation, portal pressure, and vascular geometry. Blood was withdrawn at a rate of 0.3 mL/min for 15 minutes followed by 15 minutes of stabilization. The shed blood or Haemaccel was infused at the same rate and volume as used...
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PMID: 17975475
PDF is available here.
PDF is available here.
Abstract
Perioperative volume replacement after cardiopulmonary bypass is complicated by post-bypass systemic inflammatory process. The aim of this study was to assess the effects of using two different colloid solutions as priming fluids in cardiopulmonary bypass. The study's primary end point was to measur...
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PMID: 17633136
PDF is available here.
PDF is available here.
Anesthesiology (106)1 2007
Abstract
This study demonstrates that hydroxyethyl starch 130/04 decreases the circulating levels of MMP-9 in patients undergoing abdominal surgery....
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PMID: 17197849
PDF is available here.
PDF is available here.
Anesthesia & Analgesia (104)1 2007
Abstract
Emergency Medicine Journal (23)11 2006
Abstract
No significant effect was found on whole blood coagulation by giving saline (time to peak clot increased by a mean of 106 s; (95% confidence interval (CI) -140 to 354), whereas Gelofusine delayed the time to peak by a mean of 845 s (95% CI 435 to 1255). By contrast, there was no change in the conven...
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PMID: 17057135
PDF is available here.
PDF is available here.
Abstract
No deleterious effects, clinical or cellular, were evident in this rat model when Dextran 40 or Polygeline were injected intrathecally. Thus, both substances can be considered as possible alternative materials for epidural patches....
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PMID: 16836769
PDF is available here.
PDF is available here.
Intensive Care Medicine (32)7 2006
Abstract
Intensive Care Medicine (32)7 2006
Abstract
Abstract
The different effect of Gelofusine on coagulation compared with Haemaccel does not seem to be related to the different calcium contents of the solutions....
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PMID: 16498155
PDF is available here.
PDF is available here.
Liver International (26)1 2006
Abstract
In patients with cirrhosis and ascites, human albumin appears to be more effective in preventing liver-related complications than synthetic colloid. This may be associated with decreased hospital costs....
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PMID: 16420509
PDF is available here.
PDF is available here.
Abstract
A randomized comparative study of the effect of 20% Albumin (Plasbumin) solution and 4% succinylated gelatin (helofusin) solution on homeostasis was conducted in 36 cardiosurgical patients when the solutions were used as components to fill a pump oxygenator (PO). A comparative analysis has indicated...
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PMID: 16758938
PDF is available here.
PDF is available here.
Intensive Care Medicine (31)10 2005
Stroke output variations calculated by esophageal Doppler is a reliable predictor of fluid response.
Abstract
Analysis of DeltaSOI during fluid challenge predicts response to subsequent fluid challenge and FTc is not a reliable indicator of cardiac preload....
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PMID: 16132887
PDF is available here.
PDF is available here.
Indian Pediatrics (42)3 2005
Abstract
31 patients were randomized to normal saline and 29 to gelatin polymer. Both the groups were similar with respect to age, gender, primary diagnosis, initial hemodynamic parameters and PRISM score. Pneumonia (n = 22; 36%), gut-associated sepsis (n = 13), and dengue hemorrhagic fever (n = 11) were the...
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PMID: 15817970
PDF is available here.
PDF is available here.
Abstract
The results showed that systolic blood pressure at 15, 20, 30 minutes and CVP at 15, 25, 30 minutes after positioning in the study group was maintained significantly compared to the control group and there were no significant changes in diastolic blood pressure and heart rate. There were no other co...
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PMID: 15962678
PDF is available here.
PDF is available here.
Abstract
We found a significant association between CD34+ cell content and NC density and total amount, indicating these parameters as useful to decide UCB clinical utility. Furthermore, we set up a fast procedure to process UCB units for storage. A system for NC separation and volume reduction of UCB sample...
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PMID: 16112591
PDF is available here.
PDF is available here.
Drug Safety (28)6 2005
Abstract
Anaphylaxis is a severe ADR that may also occur with commonly used drugs. It represents 2.7% of all of the ADRs reported in an Italian spontaneous reporting database....
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PMID: 15924506
PDF is available here.
PDF is available here.
Abstract
Scattered cases of immediate allergic reactions occurred in the nineties after widespread use of the original (polygeline-based) pediatric tick-borne encephalitis (TBE) vaccine and were reported to Pharmacovigilance, Chiron Vaccines. Although, still indicating a very rare frequency of about two case...
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PMID: 15542177
PDF is available here.
PDF is available here.
International Journal of Medical Microbiology (293 Suppl 37) 2004
Abstract
148 of 157 invited adult subjects who had participated in previous studies were enrolled in this extension study for evaluation of immunogenicity and safety of the second TBE booster immunization. All subjects had been previously immunized in studies with Chiron's formerly marketed TBE vaccine (cont...
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PMID: 15146994
PDF is available here.
PDF is available here.
Journal of Molecular Biology (336)3 2004
Abstract
We follow the process of protein-protein association and its rate constants (k(on)) of the beta-lactamase (TEM)-beta-lactamase inhibitor protein (BLIP) complex in crowded solution using both low and high molecular mass crowding agents. In all crowded solutions (0-40% (w/w) of ethylene glycol (EG), p...
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PMID: 15095986
PDF is available here.
PDF is available here.
Abstract
Our study demonstrates that even low doses of the polygelines Haemaccel and Gelofusine profoundly attenuate the tubular reabsorption of the low-molecular weight protein beta2-m. Atrial natriuretic peptide does not affect tubular protein reabsorption. Therefore, the rise in albuminuria during ANP inf...
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PMID: 14636299
PDF is available here.
PDF is available here.
Inflammation Research (52)10 2003
Abstract
We demonstrated for the first time histamine releasing effects of hydroxyethyl starch over a long period of time after administration. This perioperatively and for intensive care possibly relevant finding should make clinicians aware of late side effects not yet connected with the clinical use of th...
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PMID: 14520516
PDF is available here.
PDF is available here.
Abstract
Fertility and Sterility (79)3 2003
Abstract
Clinical evaluation of a polygeline-free tick-borne encephalitis vaccine for adolescents and adults.
Abstract
All subjects analyzed achieved levels of TBE antibodies postimmunization to fulfill the definition of seroconversion or a four-fold increase. The new TBE vaccine appeared to be well tolerated by subjects. Only very few febrile reactions, mainly 38.5 degrees C were reported. No serious or unexpected...
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PMID: 12531352
PDF is available here.
PDF is available here.
Abstract
We studied 44 patients using contrast echocardiography, average patient age 60.8 +/- 10.6 years, 38 men and 6 women. Abnormal right ventricular size (more than 25 mm) yielded a sensitivity of 79%, specificity of 87%, positive and negative predictive values of 92 and 68%, respectively, and a likeliho...
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PMID: 12605763
PDF is available here.
PDF is available here.
Wiadomosci Lekarskie (56)1-2 2003
Abstract
Acute normovolemic haemodilution was performed in 34 children (4-6 years old, weight: 16-68 kg) in whom major blood loss was expected during operation. Anaesthesia was induced with thiopentone, and then maintained with N2O/O2, fentanyl and pipecuronium. IPPV was used to maintain normocapnia. Heart r...
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PMID: 12901268
PDF is available here.
PDF is available here.
Abstract
Blood viscosity of the Haemaccel group (n = 11), was lower than in the blood group (n = 11): 2.7 +/- 0.2 versus 4.0 +/- 0.4 (P < 0.01). Arterial pressure, cardiac output, peripheral resistance, portal pressure, portal venous inflow and splanchnic arteriolar resistance were not significantly differen...
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PMID: 12423278
PDF is available here.
PDF is available here.
Anesthesia & Analgesia (95)5 2002
Abstract
We compared hypervolemic hemodilution (HVH) and isovolemic hemodilution (IVH) as means of perioperative blood conservation under standardized conditions. Thirty ASA status I/II adults slated for orthopedic, ear-nose-throat, or general surgery with expected blood loss of >500 mL underwent either IVH...
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PMID: 12401583
PDF is available here.
PDF is available here.
Abstract
A recent change from Haemaccel to Gelofusin as the preferred colloid for resuscitation in our region caused us to review patients who were known to be allergic to Haemaccel. As Gelofusin and Haemaccel are both modified gelatine, it seemed likely that cross reactivity could occur. Two patients who ha...
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PMID: 12180589
PDF is available here.
PDF is available here.
Fertility and Sterility (77)6 2002
Abstract
Anaesthesist (50)8 2001
Abstract
The exact double label measurements of blood volume demonstrated that polygeline, which has a volume effect of only 50%, cannot be considered to be a suitable colloidal substitute during ANH....
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PMID: 11556168
PDF is available here.
PDF is available here.
Anaesthesia (56)8 2001
Abstract
Anaesthesia (56)8 2001
Abstract
A 65-year-old patient undergoing total hip replacement under general anaesthesia suffered acute pulseless electrical activity with a fatal outcome. A kinin-mediated analphylactoid reaction following administration of a polygeline plasma expander (Haemaccel) was implicated by in vitro testing. This c...
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PMID: 11493241
PDF is available here.
PDF is available here.
Abstract
Eight rats were studied in each group. In the propranolol-treated animals, portal venous inflow was decreased (2.4 +/- 0.8 vs 3.8 +/- 0.7 mL/min per 100 g bodyweight; P < 0.01), while splanchnic arteriolar and porto-collateral resistance were increased (52.8 +/- 21.0 vs 32.8 +/- 13.0 and 6.0 +/- 1.4...
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PMID: 11446889
PDF is available here.
PDF is available here.
Intensive Care Medicine (27)5 2001
Abstract
PV determination by peripheral i. v. injection of ICG produced reliable and consistent results when a reactive hyperaemia was produced by a tourniquet prior to injection. Therefore, central venous injection of ICG may not be prerequisite for precise measurements of PV. The expected acute increase in...
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PMID: 11430552
PDF is available here.
PDF is available here.
Echocardiography (18)3 2001
Abstract
We evaluated the rate and extent of clot disruption by using external ultrasound and nongas-filled microparticles (HAEMACCEL and HAES). Human blood clots were used in this in vitro study. The percent clot reduction using the combination of ultrasound and microparticles was dose dependent and signifi...
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PMID: 11322910
PDF is available here.
PDF is available here.
Abstract
Volume replacement with Haemaccel (n=10), compared to blood (n=10), was followed by increased cardiac output and portal venous inflow (37.1 +/- 9.0 and 3.1 +/- 0.5 vs 25.9 +/- 6.8 and 2.2 +/- 0.9 ml x min(-1) x 100 g bw(-1), respectively; P<0.05), decreased viscosity (2.8 +/- 1.3 vs 3.7 +/- 1.3, res...
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PMID: 11207476
PDF is available here.
PDF is available here.
Abstract
Anesthesiology (93)5 2000
Abstract
Cardiopulmonary bypass-induced metabolic acidosis appears to be iatrogenic in nature and derived from the effect of pump prime fluid on acid-base balance. The extent of such acidosis and its duration varies according to the type of pump prime....
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PMID: 11046201
PDF is available here.
PDF is available here.
Artificial Organs (24)8 2000
Abstract
We also compared estimation accuracy using 2 blood analogues used in vitro, aqueous glycerol and red blood cells suspended in Haemaccel. The nature of the blood analogue and not only the viscosity of the fluid seems to influence estimation accuracy in our pump....
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PMID: 10971241
PDF is available here.
PDF is available here.
Brain Research (871)2 2000
Abstract
We conclude that endogenous angiotensin II does not make a major contribution to the reflex reduction in RSNA initiated by VE....
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PMID: 10899299
PDF is available here.
PDF is available here.
Abstract
The corpus cavernosum is a practical alternative means of intravenous access in the emergency setting in the dog model....
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PMID: 10901580
PDF is available here.
PDF is available here.